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Biomolecular condensation driven by phase separation can influence the biological activities of tau including its ability to polymerize tubulin into microtubules. In addition, the high concentrations that tau can reach in biomolecular condensates provide a mechanism to promote its aggregation and the formation of amyloid fibrils potentially contributing to the pathology of different tauopathies. Here, the authors discuss the role of tau phase separation in physiology and disease.<\/jats:p>","DOI":"10.1042\/ebc20220066","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T11:10:10Z","timestamp":1666005010000},"page":"1013-1021","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Phase separation of the microtubule-associated protein tau"],"prefix":"10.1042","volume":"66","author":[{"given":"Pijush","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"1German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-6581","authenticated-orcid":false,"given":"Markus","family":"Zweckstetter","sequence":"additional","affiliation":[{"name":"1German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075 G\u00f6ttingen, Germany"},{"name":"2Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Am Fa\u00dfberg 11, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"2022121609284628600_B1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/nan.12208","article-title":"Invited review: neuropathology of tauopathies: principles and practice","volume":"41","author":"Kovacs","year":"2015","journal-title":"Neuropathol. 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