{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:28:20Z","timestamp":1792124900211,"version":"4.4.0"},"reference-count":145,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Astrocytes are key homeostatic and defensive cells of the central nervous system (CNS). They undertake numerous functions during development and in adulthood to support and protect the brain through finely regulated communication with other cellular elements of the nervous tissue. In Alzheimer\u2019s disease (AD), astrocytes undergo heterogeneous morphological, molecular and functional alterations represented by reactive remodelling, asthenia and loss of function. Reactive astrocytes closely associate with amyloid \u03b2 (A\u03b2) plaques and neurofibrillary tangles in advanced AD. The specific contribution of astrocytes to AD could potentially evolve along the disease process and includes alterations in their signalling, interactions with pathological protein aggregates, metabolic and synaptic impairments. In this review, we focus on the purinergic receptor, P2X7R, and discuss the evidence that P2X7R activation contributes to altered astrocyte functions in AD. Expression of P2X7R is increased in AD brain relative to non-demented controls, and animal studies have shown that P2X7R antagonism improves cognitive and synaptic impairments in models of amyloidosis and tauopathy. While P2X7R activation can induce inflammatory signalling pathways, particularly in microglia, we focus here specifically on the contributions of astrocytic P2X7R to synaptic changes and protein aggregate clearance in AD, highlighting cell-specific roles of this purinoceptor activation that could be targeted to slow disease progression.<\/jats:p>","DOI":"10.1042\/ebc20220079","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T11:25:01Z","timestamp":1669807501000},"page":"119-130","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Astrocyte adaptation in Alzheimer\u2019s disease: a focus on astrocytic P2X7R"],"prefix":"10.1042","volume":"67","author":[{"given":"Paula","family":"Beltran-Lobo","sequence":"additional","affiliation":[{"name":"1Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, 5 Cutcombe Road, London, SE5 9RX, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew\u00a0J.","family":"Reid","sequence":"additional","affiliation":[{"name":"1Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, 5 Cutcombe Road, London, SE5 9RX, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Jimenez-Sanchez","sequence":"additional","affiliation":[{"name":"1Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, 5 Cutcombe Road, London, SE5 9RX, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Verkhratsky","sequence":"additional","affiliation":[{"name":"2Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, U.K."},{"name":"3Achucarro Center for Neuroscience, IKERBASQUE, 48011 Bilbao, Spain"},{"name":"4Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China"},{"name":"5Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, LT-01102, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz\u00a0G.","family":"Perez-Nievas","sequence":"additional","affiliation":[{"name":"1Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, 5 Cutcombe Road, London, SE5 9RX, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7898-4295","authenticated-orcid":false,"given":"Wendy","family":"Noble","sequence":"additional","affiliation":[{"name":"1Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, 5 Cutcombe Road, London, SE5 9RX, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"2023030315084450900_","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41583-018-0113-1","article-title":"Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis","volume":"20","author":"Henstridge","year":"2019","journal-title":"Nat. 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