{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:13:25Z","timestamp":1780938805379,"version":"3.54.1"},"reference-count":94,"publisher":"Portland Press Ltd.","issue":"4","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Institute for Risk Assessment","award":["FK-3-1329.421.1+2"],"award-info":[{"award-number":["FK-3-1329.421.1+2"]}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"crossref","award":["0315370D"],"award-info":[{"award-number":["0315370D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cytosolic sulphotransferase (SULT) enzymes catalyse reactions involved in xenobiotic elimination and hormone regulation. However, SULTs can also generate electrophilic reactive intermediates from certain substrates, including the activation of carcinogens. Here, we review toxicological studies of mouse strains with SULT status altered by genetic modification. Knockout mouse strains have been constructed for the enzymes Sult1a1, 1d1, 1e1, 2b1 and 4a1. In addition, transgenic strains are available for human SULT1A1\/2. Among SULT knockout mouse strains, reduced fertility (Sult1e1) and early postnatal death (Sult4a1) were observed. In contrast, Sult1a1 or Sult1d1 knockouts and SULT1A1\/2 transgenics were healthy and showed no obvious deficiencies. These strains were used in toxicological studies with 13 chemicals. Manipulation of the SULT system altered dramatically the adverse effects of many compounds; thus, very large differences in levels of DNA adducts formed in the liver or other tissues were seen with some chemicals \u2013 up to 99.2% decreases in knockouts and 83-fold increases in SULT1A1\/2 transgenics. In many cases, these changes were restricted to the tissues in which the corresponding enzymes are expressed, arguing for local activation. However, with some compounds, the kidney was an important target tissue, due to the active transfer to that organ, via the circulation, of reactive sulphuric acid esters.<\/jats:p>","DOI":"10.1042\/ebc20240030","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T12:59:21Z","timestamp":1732885161000},"page":"523-539","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sulphotransferase-mediated toxification of chemicals in mouse models: effect of knockout or humanisation of SULT genes"],"prefix":"10.1042","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-0562","authenticated-orcid":false,"given":"Hansruedi","family":"Glatt","sequence":"additional","affiliation":[{"name":"1Federal Institute for Risk Assessment (BfR), Department Food Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany"},{"name":"2German Institute of Human Nutrition (DIfE) Potsdam-Rehbr\u00fccke, Department of Nutritional Toxicology (HG & WM) and Department of Molecular Toxicology (WM), Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Meinl","sequence":"additional","affiliation":[{"name":"2German Institute of Human Nutrition (DIfE) Potsdam-Rehbr\u00fccke, Department of Nutritional Toxicology (HG & WM) and Department of Molecular Toxicology (WM), Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"2024120413562005200_B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/pnasnexus\/pgae097","article-title":"A new type of sulfation reaction: C-sulfonation for alpha,beta-unsaturated carbonyl groups by a novel sulfotransferase SULT7A1","volume":"3","author":"Kurogi","year":"2024","journal-title":"PNAS Nexus"},{"key":"2024120413562005200_B2","doi-asserted-by":"publisher","first-page":"5604","DOI":"10.1002\/cam4.1779","article-title":"Strong impact of sulfotransferases on DNA adduct formation by 4-aminobiphenyl in bladder and liver in mice","volume":"7","author":"Li","year":"2018","journal-title":"Cancer Med."},{"key":"2024120413562005200_B3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0009-2797(94)90074-4","article-title":"Sulfonation in chemical carcinogenesis \u2013 history and present status","volume":"92","author":"Miller","year":"1994","journal-title":"Chem.-Biol. 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