{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:38:58Z","timestamp":1790080738452,"version":"4.0.1"},"reference-count":95,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,12,22]]},"abstract":"<jats:p>Apicomplexa are a large group of eukaryotic, single-celled parasites, with complex life cycles that occur within a wide range of different microenvironments. They include important human pathogens such as Plasmodium, the causal agent of malaria, and Toxoplasma, which causes toxoplasmosis most often in immunocompromised individuals. Despite environmental differences in their life cycles, these parasites retain the ability to obtain nutrients, remove waste products, and control ion balances. They achieve this flexibility by relying on proteins that can deliver and remove solutes. This reliance on transport proteins for essential functions makes these pathways excellent potential targets for drug development programmes. Transport proteins are frequently key mediators of drug resistance by their ability to remove drugs from their sites of action. The study of transport processes mediated by integral membrane proteins and, in particular, identification of their physiological functions and localisation, and differentiation from host orthologues has already established new validated drug targets. Our understanding of how apicomplexan parasites have adapted to changing environmental challenges has also increased through the study of their transporters. This brief introduction to membrane transporters of apicomplexans highlights recent discoveries focusing on Plasmodium and emphasises future directions.<\/jats:p>","DOI":"10.1042\/etls20170097","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T10:15:40Z","timestamp":1513937740000},"page":"553-561","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transmembrane solute transport in the apicomplexan parasite <i>Plasmodium<\/i>"],"prefix":"10.1042","volume":"1","author":[{"given":"Henry M.","family":"Staines","sequence":"additional","affiliation":[{"name":"Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenija","family":"Slavic","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisbon 1649-028, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Krishna","sequence":"additional","affiliation":[{"name":"Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, U.K."},{"name":"St George's University Hospitals NHS Foundation Trust, Blackshaw Road, London SW17 0QT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"2021111608050479900_ETLS-2017-0097CC1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0166-6851(01)00328-0","article-title":"Apical organelles of Apicomplexa: biology and isolation by subcellular fractionation","volume":"117","author":"Blackman","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"2021111608050479900_ETLS-2017-0097CC2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00260383","article-title":"Ultrastructural study of characteristic organelles (paired organelles, micronemes, micropores) of sporozoa and related organisms","volume":"34","author":"Scholtyseck","year":"1970","journal-title":"Z. Parasitenkd."},{"issue":"Pt 11","key":"2021111608050479900_ETLS-2017-0097CC3","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1242\/jcs.111.11.1467","article-title":"The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: an unusual compartment in infected cells","volume":"111","author":"Lingelbach","year":"1998","journal-title":"J. Cell Sci."},{"key":"2021111608050479900_ETLS-2017-0097CC4","doi-asserted-by":"publisher","first-page":"e12789","DOI":"10.1111\/cmi.12789","article-title":"A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites","volume":"37","author":"Sayers","year":"2017","journal-title":"Cell. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC5","first-page":"57","article-title":"The apicoplast: a review of the derived plastid of apicomplexan parasites","volume":"7","author":"Waller","year":"2005","journal-title":"Curr. Issues Mol. Biol."},{"key":"2021111608050479900_ETLS-2017-0097CC6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.2001.81.2.495","article-title":"Membrane transport in the malaria-infected erythrocyte","volume":"81","author":"Kirk","year":"2001","journal-title":"Physiol. Rev."},{"key":"2021111608050479900_ETLS-2017-0097CC7","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/S0020-7519(01)00254-5","article-title":"Transport proteins of Plasmodium falciparum: defining the limits of metabolism","volume":"31","author":"Krishna","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"2021111608050479900_ETLS-2017-0097CC8","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.pt.2009.03.006","article-title":"Purine uptake in Plasmodium: transport versus metabolism","volume":"25","author":"Kirk","year":"2009","journal-title":"Trends Parasitol."},{"key":"2021111608050479900_ETLS-2017-0097CC9","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1365-2958.2009.06863.x","article-title":"Membrane transport proteins of the malaria parasite","volume":"74","author":"Martin","year":"2009","journal-title":"Mol. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC10","doi-asserted-by":"publisher","first-page":"R26","DOI":"10.1186\/gb-2005-6-3-r26","article-title":"The \u2018permeome\u2019 of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum","volume":"6","author":"Martin","year":"2005","journal-title":"Genome Biol."},{"key":"2021111608050479900_ETLS-2017-0097CC11","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.pt.2010.03.004","article-title":"Exploiting the therapeutic potential of Plasmodium falciparum solute transporters","volume":"26","author":"Staines","year":"2010","journal-title":"Trends Parasitol."},{"key":"2021111608050479900_ETLS-2017-0097CC12","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1186\/s12864-016-2632-3","article-title":"Comparative genomics reveals Cyclospora cayetanensis possesses coccidia-like metabolism and invasion components but unique surface antigens","volume":"17","author":"Liu","year":"2016","journal-title":"BMC Genomics"},{"key":"2021111608050479900_ETLS-2017-0097CC13","doi-asserted-by":"publisher","first-page":"e1003191","DOI":"10.1371\/journal.ppat.1003191","article-title":"The Plasmodium berghei Ca2+\/H+ exchanger, PbCAX, is essential for tolerance to environmental Ca2+ during sexual development","volume":"9","author":"Guttery","year":"2013","journal-title":"PLoS Pathog."},{"key":"2021111608050479900_ETLS-2017-0097CC14","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.cell.2017.06.030","article-title":"Functional profiling of a Plasmodium genome reveals an abundance of essential genes","volume":"170","author":"Bushell","year":"2017","journal-title":"Cell"},{"key":"2021111608050479900_ETLS-2017-0097CC15","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.cell.2016.08.019","article-title":"A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes","volume":"166","author":"Sidik","year":"2016","journal-title":"Cell"},{"key":"2021111608050479900_ETLS-2017-0097CC16","doi-asserted-by":"publisher","first-page":"10519","DOI":"10.1038\/ncomms10519","article-title":"Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite","volume":"7","author":"Kenthirapalan","year":"2016","journal-title":"Nat. Commun."},{"key":"2021111608050479900_ETLS-2017-0097CC17","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1126\/science.1193225","article-title":"Spiroindolones, a potent compound class for the treatment of malaria","volume":"329","author":"Rottmann","year":"2010","journal-title":"Science"},{"key":"2021111608050479900_ETLS-2017-0097CC18","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1083\/jcb.120.2.385","article-title":"A family of cation ATPase-like molecules from Plasmodium falciparum","volume":"120","author":"Krishna","year":"1993","journal-title":"J. Cell Biol."},{"key":"2021111608050479900_ETLS-2017-0097CC19","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1056\/NEJMoa1315860","article-title":"Spiroindolone KAE609 for falciparum and vivax malaria","volume":"371","author":"White","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2021111608050479900_ETLS-2017-0097CC20","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/nature09107","article-title":"Thousands of chemical starting points for antimalarial lead identification","volume":"465","author":"Gamo","year":"2010","journal-title":"Nature"},{"key":"2021111608050479900_ETLS-2017-0097CC21","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nature09099","article-title":"Chemical genetics of Plasmodium falciparum","volume":"465","author":"Guiguemde","year":"2010","journal-title":"Nature"},{"key":"2021111608050479900_ETLS-2017-0097CC22","doi-asserted-by":"publisher","first-page":"9059","DOI":"10.1073\/pnas.0802982105","article-title":"In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen","volume":"105","author":"Plouffe","year":"2008","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021111608050479900_ETLS-2017-0097CC23","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.chom.2012.12.006","article-title":"Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials","volume":"13","author":"Spillman","year":"2013","journal-title":"Cell Host Microbe"},{"key":"2021111608050479900_ETLS-2017-0097CC24","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1021\/cb500616x","article-title":"Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials","volume":"10","author":"Flannery","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"2021111608050479900_ETLS-2017-0097CC25","doi-asserted-by":"publisher","first-page":"E5455","DOI":"10.1073\/pnas.1414221111","article-title":"(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium","volume":"111","author":"Jim\u00e9nez-D\u00edaz","year":"2014","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021111608050479900_ETLS-2017-0097CC26","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/mmi.12765","article-title":"Diverse chemotypes disrupt ion homeostasis in the malaria parasite","volume":"94","author":"Lehane","year":"2014","journal-title":"Mol. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC27","doi-asserted-by":"publisher","first-page":"5521","DOI":"10.1038\/ncomms6521","article-title":"Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum","volume":"5","author":"Vaidya","year":"2014","journal-title":"Nat. Commun."},{"key":"2021111608050479900_ETLS-2017-0097CC28","doi-asserted-by":"publisher","first-page":"27806","DOI":"10.1038\/srep27806","article-title":"Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor","volume":"6","author":"Goldgof","year":"2016","journal-title":"Sci. Rep."},{"key":"2021111608050479900_ETLS-2017-0097CC29","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/mmi.13324","article-title":"Calcium signalling in malaria parasites","volume":"100","author":"Brochet","year":"2016","journal-title":"Mol. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC30","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ceca.2014.12.010","article-title":"The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp","volume":"57","author":"Lourido","year":"2015","journal-title":"Cell Calcium"},{"key":"2021111608050479900_ETLS-2017-0097CC31","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.chom.2009.05.017","article-title":"Calcium-dependent signaling and kinases in apicomplexan parasites","volume":"5","author":"Billker","year":"2009","journal-title":"Cell Host Microbe"},{"key":"2021111608050479900_ETLS-2017-0097CC32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molbiopara.2009.01.003","article-title":"Molecular machinery of signal transduction and cell cycle regulation in Plasmodium","volume":"165","author":"Koyama","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"2021111608050479900_ETLS-2017-0097CC33","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S1369-5274(03)00091-2","article-title":"Calcium regulation in protozoan parasites","volume":"6","author":"Moreno","year":"2003","journal-title":"Curr. Opin. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC34","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1093\/molbev\/msl026","article-title":"Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the Apicomplexa","volume":"23","author":"Nagamune","year":"2006","journal-title":"Mol. Biol. Evol."},{"key":"2021111608050479900_ETLS-2017-0097CC35","doi-asserted-by":"publisher","first-page":"e26218","DOI":"10.1371\/journal.pone.0026218","article-title":"Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites","volume":"6","author":"Prole","year":"2011","journal-title":"PLoS ONE"},{"key":"2021111608050479900_ETLS-2017-0097CC36","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/nature01813","article-title":"Artemisinins target the SERCA of Plasmodium falciparum","volume":"424","author":"Eckstein-Ludwig","year":"2003","journal-title":"Nature"},{"key":"2021111608050479900_ETLS-2017-0097CC37","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1093\/infdis\/jit171","article-title":"Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes","volume":"208","author":"Pulcini","year":"2013","journal-title":"J. Infect. Dis."},{"key":"2021111608050479900_ETLS-2017-0097CC38","doi-asserted-by":"publisher","first-page":"14193","DOI":"10.1038\/ncomms14193","article-title":"SC83288 is a clinical development candidate for the treatment of severe malaria","volume":"8","author":"Pegoraro","year":"2017","journal-title":"Nat. Commun."},{"key":"2021111608050479900_ETLS-2017-0097CC39","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1111\/j.1365-2958.2010.07187.x","article-title":"PfCHA is a mitochondrial divalent cation\/H+ antiporter in Plasmodium falciparum","volume":"76","author":"Rotmann","year":"2010","journal-title":"Mol. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC40","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/1475-2875-11-254","article-title":"A yeast expression system for functional and pharmacological studies of the malaria parasite Ca2+\/H+ antiporter","volume":"11","author":"Salcedo-Sora","year":"2012","journal-title":"Malar. J."},{"key":"2021111608050479900_ETLS-2017-0097CC41","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1083\/jcb.201510019","article-title":"Ca2+\/H+ exchange by acidic organelles regulates cell migration in vivo","volume":"212","author":"Melchionda","year":"2016","journal-title":"J. Cell Biol."},{"key":"2021111608050479900_ETLS-2017-0097CC42","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1017\/S1431927604040875","article-title":"Polyphosphate content and fine structure of acidocalcisomes of Plasmodium falciparum","volume":"10","author":"Ruiz","year":"2004","journal-title":"Microsc. Microanal."},{"key":"2021111608050479900_ETLS-2017-0097CC43","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.2174\/1568026617666170130121042","article-title":"Insp3 signaling in apicomplexan parasites","volume":"17","author":"Garcia","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"2021111608050479900_ETLS-2017-0097CC44","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.15252\/emmm.201403868","article-title":"ZIPCO, a putative metal ion transporter, is crucial for Plasmodium liver-stage development","volume":"6","author":"Sahu","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"2021111608050479900_ETLS-2017-0097CC45","doi-asserted-by":"publisher","first-page":"10403","DOI":"10.1038\/ncomms10403","article-title":"A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium","volume":"7","author":"Slavic","year":"2016","journal-title":"Nat. Commun."},{"key":"2021111608050479900_ETLS-2017-0097CC46","doi-asserted-by":"publisher","first-page":"42850","DOI":"10.1038\/srep42850","article-title":"Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+\/H+ exchanger","volume":"7","author":"Labarbuta","year":"2017","journal-title":"Sci. Rep."},{"key":"2021111608050479900_ETLS-2017-0097CC47","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1365-2958.2005.04556.x","article-title":"Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance","volume":"56","author":"Bray","year":"2005","journal-title":"Mol. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC48","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1073\/pnas.1417102112","article-title":"Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter","volume":"112","author":"Juge","year":"2015","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021111608050479900_ETLS-2017-0097CC49","doi-asserted-by":"publisher","first-page":"e1004085","DOI":"10.1371\/journal.pgen.1004085","article-title":"Metabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolism","volume":"10","author":"Lewis","year":"2014","journal-title":"PLoS Genet."},{"key":"2021111608050479900_ETLS-2017-0097CC50","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1126\/science.1175667","article-title":"Chloroquine transport via the malaria parasite's chloroquine resistance transporter","volume":"325","author":"Martin","year":"2009","journal-title":"Science"},{"key":"2021111608050479900_ETLS-2017-0097CC51","doi-asserted-by":"publisher","first-page":"14552","DOI":"10.1038\/srep14552","article-title":"Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities","volume":"5","author":"Pulcini","year":"2015","journal-title":"Sci. Rep."},{"key":"2021111608050479900_ETLS-2017-0097CC52","doi-asserted-by":"publisher","first-page":"e00150","DOI":"10.1042\/BSR20140134","article-title":"1H-NMR metabolite profiles of different strains of Plasmodium falciparum","volume":"34","author":"Teng","year":"2014","journal-title":"Biosci. Rep."},{"key":"2021111608050479900_ETLS-2017-0097CC53","doi-asserted-by":"publisher","first-page":"16109","DOI":"10.1074\/jbc.M117.805200","article-title":"Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes","volume":"292","author":"Bakouh","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2021111608050479900_ETLS-2017-0097CC54","doi-asserted-by":"publisher","first-page":"7272","DOI":"10.1074\/jbc.274.11.7272","article-title":"Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter","volume":"274","author":"Woodrow","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2021111608050479900_ETLS-2017-0097CC55","doi-asserted-by":"publisher","first-page":"7476","DOI":"10.1073\/pnas.1330865100","article-title":"Validation of the hexose transporter of Plasmodium falciparum as a novel drug target","volume":"100","author":"Joet","year":"2003","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021111608050479900_ETLS-2017-0097CC56","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1128\/AAC.01739-10","article-title":"Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle","volume":"55","author":"Slavic","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"2021111608050479900_ETLS-2017-0097CC57","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1111\/j.1365-2958.2010.07060.x","article-title":"Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality","volume":"75","author":"Slavic","year":"2010","journal-title":"Mol. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC58","doi-asserted-by":"publisher","first-page":"6721","DOI":"10.1038\/ncomms7721","article-title":"A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum","volume":"6","author":"Marchetti","year":"2015","journal-title":"Nat. Commun."},{"key":"2021111608050479900_ETLS-2017-0097CC59","doi-asserted-by":"publisher","first-page":"6284","DOI":"10.1038\/ncomms7284","article-title":"Identity of a Plasmodium lactate\/H+ symporter structurally unrelated to human transporters","volume":"6","author":"Wu","year":"2015","journal-title":"Nat. Commun."},{"key":"2021111608050479900_ETLS-2017-0097CC60","doi-asserted-by":"publisher","first-page":"7407","DOI":"10.1128\/AAC.00218-16","article-title":"A novel FRET-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters","volume":"60","author":"Kraft","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"2021111608050479900_ETLS-2017-0097CC61","doi-asserted-by":"publisher","first-page":"e0123598","DOI":"10.1371\/journal.pone.0123598","article-title":"Identification of selective inhibitors of the Plasmodium falciparum hexose transporter PfHT by screening focused libraries of anti-malarial compounds","volume":"10","author":"Ortiz","year":"2015","journal-title":"PLoS ONE"},{"key":"2021111608050479900_ETLS-2017-0097CC62","doi-asserted-by":"publisher","first-page":"e1006172","DOI":"10.1371\/journal.ppat.1006172","article-title":"Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale","volume":"13","author":"Golldack","year":"2017","journal-title":"PLoS Pathog."},{"key":"2021111608050479900_ETLS-2017-0097CC63","doi-asserted-by":"publisher","first-page":"e1006180","DOI":"10.1371\/journal.ppat.1006180","article-title":"The malaria parasite's lactate transporter PfFNT is the target of antiplasmodial compounds identified in whole cell phenotypic screens","volume":"13","author":"Hapuarachchi","year":"2017","journal-title":"PLoS Pathog."},{"key":"2021111608050479900_ETLS-2017-0097CC64","doi-asserted-by":"publisher","first-page":"20558","DOI":"10.1074\/jbc.M113.482992","article-title":"Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum","volume":"288","author":"Augagneur","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2021111608050479900_ETLS-2017-0097CC65","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1111\/j.1365-2958.2011.07767.x","article-title":"The novel putative transporter NPT1 plays a critical role in early stages of Plasmodium berghei sexual development","volume":"81","author":"Boisson","year":"2011","journal-title":"Mol. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC66","doi-asserted-by":"publisher","first-page":"14455","DOI":"10.1038\/ncomms14455","article-title":"Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites","volume":"8","author":"Rajendran","year":"2017","journal-title":"Nat. Commun."},{"key":"2021111608050479900_ETLS-2017-0097CC67","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nature09606","article-title":"Sugar transporters for intercellular exchange and nutrition of pathogens","volume":"468","author":"Chen","year":"2010","journal-title":"Nature"},{"key":"2021111608050479900_ETLS-2017-0097CC68","doi-asserted-by":"publisher","first-page":"6398","DOI":"10.1073\/pnas.0802384105","article-title":"Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption","volume":"105","author":"Ellekvist","year":"2008","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021111608050479900_ETLS-2017-0097CC69","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.bbrc.2017.08.128","article-title":"Functional characterization of malaria parasites deficient in the K+ channel Kch2","volume":"493","author":"Ellekvist","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021111608050479900_ETLS-2017-0097CC70","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1475-2875-7-19","article-title":"Characterization of two putative potassium channels in Plasmodium falciparum","volume":"7","author":"Waller","year":"2008","journal-title":"Malar J."},{"key":"2021111608050479900_ETLS-2017-0097CC71","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nsmb.1431","article-title":"Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum","volume":"15","author":"Newby","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2021111608050479900_ETLS-2017-0097CC72","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nature13306","article-title":"Crystal structure of the human glucose transporter GLUT1","volume":"510","author":"Deng","year":"2014","journal-title":"Nature"},{"key":"2021111608050479900_ETLS-2017-0097CC73","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1126\/science.1239002","article-title":"Structural basis for the counter-transport mechanism of a H+\/Ca2+ exchanger","volume":"341","author":"Nishizawa","year":"2013","journal-title":"Science"},{"key":"2021111608050479900_ETLS-2017-0097CC74","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nature12233","article-title":"Structural basis for alternating access of a eukaryotic calcium\/proton exchanger","volume":"499","author":"Waight","year":"2013","journal-title":"Nature"},{"key":"2021111608050479900_ETLS-2017-0097CC75","doi-asserted-by":"publisher","first-page":"26406","DOI":"10.1074\/jbc.M109.090340","article-title":"Purified E255L mutant SERCA1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins","volume":"285","author":"Cardi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2021111608050479900_ETLS-2017-0097CC76","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.pep.2016.06.008","article-title":"High-level cell-free production of the malarial lactate transporter PfFNT as a basis for crystallization trials and directional transport studies","volume":"126","author":"Holm-Bertelsen","year":"2016","journal-title":"Protein Expr. Purif."},{"key":"2021111608050479900_ETLS-2017-0097CC77","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.pep.2017.08.005","article-title":"Engineering and purification of a thermostable, high-yield, variant of PfCRT, the Plasmodium falciparum chloroquine resistance transporter","volume":"141","author":"Wright","year":"2018","journal-title":"Protein Expr. Purif."},{"key":"2021111608050479900_ETLS-2017-0097CC78","doi-asserted-by":"crossref","first-page":"C1576","DOI":"10.1152\/ajpcell.2001.280.6.C1576","article-title":"Perturbation of the pump-leak balance for Na+ and K+ in malaria-infected erythrocytes","volume":"280","author":"Staines","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"Pt 3","key":"2021111608050479900_ETLS-2017-0097CC79","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1042\/bj3340525","article-title":"Increased choline transport in erythrocytes from mice infected with the malaria parasite Plasmodium vinckei vinckei","volume":"334","author":"Staines","year":"1998","journal-title":"Biochem. J."},{"key":"2021111608050479900_ETLS-2017-0097CC80","doi-asserted-by":"publisher","first-page":"4072","DOI":"10.1038\/s41598-017-04424-y","article-title":"Uptake and metabolism of arginine impact Plasmodium development in the liver","volume":"7","author":"Meireles","year":"2017","journal-title":"Sci. Rep."},{"key":"2021111608050479900_ETLS-2017-0097CC81","doi-asserted-by":"publisher","first-page":"e12646","DOI":"10.1111\/cmi.12646","article-title":"GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection","volume":"19","author":"Meireles","year":"2017","journal-title":"Cell. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC82","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1111\/j.1462-5822.2009.01342.x","article-title":"Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells","volume":"11","author":"Prud\u00eancio","year":"2009","journal-title":"Cell. Microbiol."},{"key":"2021111608050479900_ETLS-2017-0097CC83","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2014.03.024","article-title":"SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel","volume":"157","author":"Qiu","year":"2014","journal-title":"Cell"},{"key":"2021111608050479900_ETLS-2017-0097CC84","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1126\/science.1252826","article-title":"Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC","volume":"344","author":"Voss","year":"2014","journal-title":"Science"},{"key":"2021111608050479900_ETLS-2017-0097CC85","doi-asserted-by":"publisher","first-page":"D539","DOI":"10.7554\/eLife.23217","article-title":"Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate","volume":"6","author":"Counihan","year":"2017","journal-title":"eLife"},{"key":"2021111608050479900_ETLS-2017-0097CC86","doi-asserted-by":"publisher","first-page":"e23485","DOI":"10.7554\/eLife.23485","article-title":"An essential dual-function complex mediates erythrocyte invasion and channel-mediated nutrient uptake in malaria parasites","volume":"6","author":"Ito","year":"2017","journal-title":"eLife"},{"key":"2021111608050479900_ETLS-2017-0097CC87","doi-asserted-by":"publisher","first-page":"e23239","DOI":"10.7554\/eLife.23239","article-title":"The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake","volume":"6","author":"Sherling","year":"2017","journal-title":"eLife"},{"key":"2021111608050479900_ETLS-2017-0097CC88","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1182\/blood-2011-01-329300","article-title":"Erythrocyte peripheral type benzodiazepine receptor\/voltage-dependent anion channels are upregulated by Plasmodium falciparum","volume":"118","author":"Bouyer","year":"2011","journal-title":"Blood"},{"key":"2021111608050479900_ETLS-2017-0097CC89","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.ijpara.2006.12.013","article-title":"Electrophysiological studies of malaria parasite-infected erythrocytes: current status","volume":"37","author":"Staines","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"2021111608050479900_ETLS-2017-0097CC90","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1073\/pnas.1600459113","article-title":"Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7","volume":"113","author":"Ismail","year":"2016","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021111608050479900_ETLS-2017-0097CC91","doi-asserted-by":"publisher","first-page":"10111","DOI":"10.1038\/ncomms10111","article-title":"Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"2021111608050479900_ETLS-2017-0097CC92","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.febslet.2009.11.097","article-title":"The carbon and energy sources of the non-photosynthetic plastid in the malaria parasite","volume":"584","author":"Lim","year":"2010","journal-title":"FEBS Lett."},{"key":"2021111608050479900_ETLS-2017-0097CC93","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/BF01868451","article-title":"Use of Xenopus oocytes for the functional expression of plasma membrane proteins","volume":"117","author":"Sigel","year":"1990","journal-title":"J. Membr. Biol."},{"key":"2021111608050479900_ETLS-2017-0097CC94","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1083\/jcb.124.3.351","article-title":"Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases","volume":"124","author":"Cunningham","year":"1994","journal-title":"J. Cell Biol."},{"key":"2021111608050479900_ETLS-2017-0097CC95","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1128\/MCB.16.5.2226","article-title":"Calcineurin inhibits VCX1-dependent H+\/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae","volume":"16","author":"Cunningham","year":"1996","journal-title":"Mol. Cell. Biol."}],"container-title":["Emerging Topics in Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/emergtoplifesci\/article-pdf\/1\/6\/553\/484059\/etls-2017-0097c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/emergtoplifesci\/article-pdf\/1\/6\/553\/484059\/etls-2017-0097c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T08:05:25Z","timestamp":1637049925000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/emergtoplifesci\/article\/1\/6\/553\/11659\/Transmembrane-solute-transport-in-the-apicomplexan"}},"subtitle":[],"editor":[{"given":"Roberto","family":"Docampo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,22]]},"references-count":95,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,12,22]]},"published-print":{"date-parts":[[2017,12,22]]}},"URL":"https:\/\/doi.org\/10.1042\/etls20170097","relation":{},"ISSN":["2397-8554","2397-8562"],"issn-type":[{"value":"2397-8554","type":"print"},{"value":"2397-8562","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,22]]}}}