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The location and the nature of mutation modulate the underlying disease pathophysiology resulting in varying disease manifestations. Potential toxic effects of these mutations likely affect key major cellular processes such as transcriptional regulation, mitochondrial functioning, ion channel dysfunction and synaptic transmission. Involvement of several common pathways suggests interlinked function of genes implicated in the disease pathogenesis. A better understanding of the shared and distinct molecular pathogenic mechanisms in these diseases is required to develop targeted therapeutic tools and interventions for disease management. The prime focus of this review is to elaborate on how expanded \u2018CAG\u2019 repeats contribute to the common modes of neurotoxicity and their possible therapeutic targets in management of such devastating disorders.<\/jats:p>","DOI":"10.1042\/etls20230013","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:41:56Z","timestamp":1693892516000},"page":"289-312","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The molecular mechanisms of spinocerebellar ataxias for DNA repeat expansion in disease"],"prefix":"10.1042","volume":"7","author":[{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishu","family":"Tyagi","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-8396","authenticated-orcid":false,"given":"Mohammed","family":"Faruq","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"2023121411242564100_ETLS-2023-0013CC1","first-page":"148","article-title":"Genetics of the SCA6 gene in a large family segregating an autosomal dominant \u2018pure\u2019 cerebellar ataxia","volume":"36","year":"1999","journal-title":"J. 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