{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:36:38Z","timestamp":1792791398986,"version":"4.5.0"},"reference-count":269,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2021\/01656-3"],"award-info":[{"award-number":["2021\/01656-3"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2021\/05406-1"],"award-info":[{"award-number":["2021\/05406-1"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2017\/19731-6"],"award-info":[{"award-number":["2017\/19731-6"]}]},{"name":"Independent Research Fund Denmark fellowship","id":[{"id":"https:\/\/ror.org\/05svhj534","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stress exposure is associated with psychiatric conditions, such as depression, anxiety, and post-traumatic stress disorder (PTSD). It is also a vulnerability factor to developing or reinstating substance use disorder. Stress causes several changes in the neuro-immune-endocrine axis, potentially resulting in prolonged dysfunction and diseases. Changes in several transmitters, including serotonin, dopamine, glutamate, gamma-aminobutyric acid (GABA), glucocorticoids, and cytokines, are associated with psychiatric disorders or behavioral alterations in preclinical studies. Complex and interacting mechanisms make it very difficult to understand the physiopathology of psychiatry conditions; therefore, studying regulatory mechanisms that impact these alterations is a good approach. In the last decades, the impact of stress on biology through epigenetic markers, which directly impact gene expression, is under intense investigation; these mechanisms are associated with behavioral alterations in animal models after stress or drug exposure, for example. The endocannabinoid (eCB) system modulates stress response, reward circuits, and other physiological functions, including hypothalamus\u2013pituitary\u2013adrenal axis activation and immune response. eCBs, for example, act retrogradely at presynaptic neurons, limiting the release of neurotransmitters, a mechanism implicated in the antidepressant and anxiolytic effects after stress. Epigenetic mechanisms can impact the expression of eCB system molecules, which in turn can regulate epigenetic mechanisms. This review will present evidence of how the eCB system and epigenetic mechanisms interact and the consequences of this interaction in modulating behavioral changes after stress exposure in preclinical studies or psychiatric conditions. Moreover, evidence that correlates the involvement of the eCB system and epigenetic mechanisms in drug abuse contexts will be discussed.<\/jats:p>","DOI":"10.1042\/ns20220034","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T05:58:22Z","timestamp":1689055102000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders"],"prefix":"10.1042","volume":"7","author":[{"given":"Arthur\u00a0A.","family":"Coelho","sequence":"first","affiliation":[{"name":"1Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Brazil"},{"name":"2Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1vio","family":"Lima-Bastos","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Brazil"},{"name":"2Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro\u00a0H.","family":"Gobira","sequence":"additional","affiliation":[{"name":"2Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2069-3524","authenticated-orcid":false,"given":"Sabrina\u00a0F.","family":"Lisboa","sequence":"additional","affiliation":[{"name":"2Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"2023072505495929600_B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnbeh.2018.00127","article-title":"A comprehensive overview on stress neurobiology: basic concepts and clinical implications","volume":"12","author":"Godoy","year":"2018","journal-title":"Front Behav. Neurosci."},{"key":"2023072505495929600_B2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.ge.19.120185.001233","article-title":"Steroid receptor regulated transcription of specific genes and gene networks","volume":"19","author":"Yamamoto","year":"1985","journal-title":"Annu. Rev. Genet."},{"key":"2023072505495929600_B3","doi-asserted-by":"publisher","first-page":"15603","DOI":"10.1073\/pnas.0407008101","article-title":"Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes","volume":"101","author":"Wang","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023072505495929600_B4","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.tins.2022.10.001","article-title":"Convergent actions of stress and stimulants via epigenetic regulation of neural circuitry","volume":"45","author":"Murphy","year":"2022","journal-title":"Trends Neurosci."},{"key":"2023072505495929600_B5","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.biopsych.2020.12.026","article-title":"Amygdala circuit substrates for stress adaptation and adversity","volume":"89","author":"Zhang","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s41386-021-01155-7","article-title":"Prefrontal cortex, amygdala, and threat processing: implications for PTSD","volume":"47","author":"Alexandra Kredlow","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"2023072505495929600_B7","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/mp.2015.196","article-title":"The dynamics of the stress neuromatrix","volume":"21","author":"Sousa","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"2023072505495929600_B8","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/j.neuron.2021.03.035","article-title":"The mouse prefrontal cortex: Unity in diversity","volume":"109","author":"Le Merre","year":"2021","journal-title":"Neuron"},{"key":"2023072505495929600_B9","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41386-021-01132-0","article-title":"The role of prefrontal cortex in cognitive control and executive function","volume":"47","author":"Friedman","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"2023072505495929600_B10","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/jne.12272","article-title":"The medial prefrontal cortex: coordinator of autonomic, neuroendocrine and behavioural responses to stress","volume":"27","author":"McKlveen","year":"2015","journal-title":"J. Neuroendocrinol."},{"key":"2023072505495929600_B11","doi-asserted-by":"publisher","first-page":"e82688","DOI":"10.7554\/eLife.82688","article-title":"Rostral and caudal basolateral amygdala engage distinct circuits in the prelimbic and infralimbic prefrontal cortex","volume":"11","author":"Manoocheri","year":"2022","journal-title":"eLife"},{"key":"2023072505495929600_B12","doi-asserted-by":"publisher","first-page":"e2725","DOI":"10.1371\/journal.pone.0002725","article-title":"Prelimbic and infralimbic prefrontal cortex interact during fast network oscillations","volume":"3","author":"van Aerde","year":"2008","journal-title":"PloS ONE"},{"key":"2023072505495929600_B13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/cne.20738","article-title":"Prefrontal cortex in the rat: projections to subcortical autonomic, motor, and limbic centers","volume":"492","author":"Gabbott","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"2023072505495929600_B14","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/syn.10279","article-title":"Differential projections of the infralimbic and prelimbic cortex in the rat","volume":"51","author":"Vertes","year":"2004","journal-title":"Synapse"},{"key":"2023072505495929600_B15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nrn3138","article-title":"The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission","volume":"13","author":"Popoli","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"2023072505495929600_B16","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1016\/S1734-1140(13)71527-5","article-title":"Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems","volume":"65","author":"G\u0105dek-Michalska","year":"2013","journal-title":"Pharmacological Rep."},{"key":"2023072505495929600_B17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jpsychires.2011.08.006","article-title":"Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims","volume":"46","author":"Pandey","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"2023072505495929600_B18","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.ceb.2011.09.002","article-title":"Cell atrophy and loss in depression: reversal by antidepressant treatment","volume":"23","author":"Banasr","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072505495929600_B19","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1097\/01.wnr.0000071767.24455.10","article-title":"Selectively reduced regional cortical volumes in post-traumatic stress disorder","volume":"14","author":"Rauch","year":"2003","journal-title":"Neuroreport"},{"key":"2023072505495929600_B20","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/nn.4087","article-title":"Stress weakens prefrontal networks: molecular insults to higher cognition","volume":"18","author":"Arnsten","year":"2015","journal-title":"Nat. Neurosci."},{"key":"2023072505495929600_B21","doi-asserted-by":"publisher","first-page":"24705470211029254","DOI":"10.1177\/24705470211029254","article-title":"Chronic stress weakens connectivity in the prefrontal cortex: architectural and molecular changes","volume":"5","author":"Woo","year":"2021","journal-title":"Chronic Stress"},{"key":"2023072505495929600_B22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.12688\/f1000research.21201.1","article-title":"Fear conditioning and the basolateral amygdala","volume":"9","author":"Sun","year":"2020","journal-title":"F1000Research"},{"key":"2023072505495929600_B23","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1523\/JNEUROSCI.4985-10.2011","article-title":"Central amygdala activity during fear conditioning","volume":"31","author":"Duvarci","year":"2011","journal-title":"J. Neurosci."},{"key":"2023072505495929600_B24","doi-asserted-by":"publisher","first-page":"132044","DOI":"10.1016\/j.chemosphere.2021.132044","article-title":"Hyperactivity of basolateral amygdala mediates behavioral deficits in mice following exposure to bisphenol A and its analogue alternative","volume":"287","author":"Hu","year":"2022","journal-title":"Chemosphere"},{"key":"2023072505495929600_B25","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.neuroscience.2018.08.004","article-title":"Aberrant amygdala-dependent fear memory in corticosterone-treated mice","volume":"388","author":"Inagaki","year":"2018","journal-title":"Neuroscience"},{"key":"2023072505495929600_B26","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/S0006-3223(02)01314-8","article-title":"Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals","volume":"51","author":"Siegle","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B27","doi-asserted-by":"publisher","first-page":"14324","DOI":"10.1073\/pnas.1105371108","article-title":"Larger amygdala but no change in hippocampal volume in 10-year-old children exposed to maternal depressive symptomatology since birth","volume":"108","author":"Lupien","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023072505495929600_B28","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/S0006-3223(01)01359-2","article-title":"Enlargement of the amygdala in patients with a first episode of major depression","volume":"51","author":"Frodl","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B29","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.biopsych.2015.03.017","article-title":"Neuronal circuits for fear expression and recovery: recent advances and potential therapeutic strategies","volume":"78","author":"Dejean","year":"2015","journal-title":"Biol. Psychiatr."},{"key":"2023072505495929600_B30","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/1098-1063(2000)10:4%3c411::AID-HIPO7%3e3.0.CO;2-A","article-title":"Hippocampo-prefrontal cortex pathway: Anatomical and electrophysiological characteristics","volume":"10","author":"Thierry","year":"2000","journal-title":"Hippocampus"},{"key":"2023072505495929600_B31","doi-asserted-by":"publisher","first-page":"9987","DOI":"10.1523\/JNEUROSCI.23-31-09987.2003","article-title":"Convergence and interaction of hippocampal and amygdalar projections within the prefrontal cortex in the rat","volume":"23","author":"Ishikawa","year":"2003","journal-title":"J. Neurosci."},{"key":"2023072505495929600_B32","doi-asserted-by":"publisher","first-page":"4868","DOI":"10.1523\/JNEUROSCI.3579-16.2017","article-title":"Synaptic targeting of double-projecting ventral CA1 hippocampal neurons to the medial prefrontal cortex and basal amygdala","volume":"37","author":"Kim","year":"2017","journal-title":"J. Neurosci."},{"key":"2023072505495929600_B33","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00213-018-5109-z","article-title":"Hippocampal network oscillations at the interplay between innate anxiety and learned fear","volume":"236","author":"\u00c7al\u0131\u015fkan","year":"2019","journal-title":"Psychopharmacology (Berl.)"},{"key":"2023072505495929600_B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnbeh.2018.00329","article-title":"The neurobiology of fear generalization","volume":"12","author":"Asok","year":"2019","journal-title":"Front Behav Neurosci."},{"key":"2023072505495929600_B35","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1101\/lm.037291.114","article-title":"Stress effects on the hippocampus: a critical review","volume":"22","author":"Kim","year":"2015","journal-title":"Learn. Memory"},{"key":"2023072505495929600_B36","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.neubiorev.2021.06.035","article-title":"The neurobiology of human fear generalization: meta-analysis and working neural model","volume":"128","author":"Webler","year":"2021","journal-title":"Neurosci. Biobehavioral Rev."},{"key":"2023072505495929600_B37","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ejphar.2008.01.014","article-title":"Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice","volume":"583","author":"Murray","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"2023072505495929600_B38","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S0006-3223(96)00229-6","article-title":"Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder","volume":"40","author":"Gurvits","year":"1996","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B39","doi-asserted-by":"publisher","first-page":"2470547020944553","DOI":"10.1177\/2470547020944553","article-title":"Hippocampal and amygdalar volume changes in major depressive disorder: a targeted review and focus on stress","volume":"4","author":"Nolan","year":"2020","journal-title":"Chronic Stress"},{"key":"2023072505495929600_B40","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.neubiorev.2006.03.004","article-title":"A meta-analysis of structural brain abnormalities in PTSD","volume":"30","author":"Karl","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2023072505495929600_B41","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1176\/ajp.152.7.973","article-title":"MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder","volume":"152","author":"Bremner","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"2023072505495929600_B42","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1038\/nn958","article-title":"Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma","volume":"5","author":"Gilbertson","year":"2002","journal-title":"Nat. Neurosci."},{"key":"2023072505495929600_B43","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41582-019-0284-z","article-title":"Cannabinoids and the expanded endocannabinoid system in neurological disorders","volume":"16","author":"Cristino","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"2023072505495929600_B44","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1097\/00008877-200509000-00005","article-title":"A role for cannabinoid CB1 receptors in mood and anxiety disorders","volume":"16","author":"Witkin","year":"2005","journal-title":"Behav. Pharmacol."},{"key":"2023072505495929600_B45","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nature00839","article-title":"The endogenous cannabinoid system controls extinction of aversive memories","volume":"418","author":"Marsicano","year":"2002","journal-title":"Nature"},{"key":"2023072505495929600_B46","doi-asserted-by":"publisher","first-page":"pyv005","DOI":"10.1093\/ijnp\/pyv005","article-title":"Increased contextual fear conditioning in iNOS knockout mice: additional evidence for the involvement of nitric oxide in stress-related disorders and contribution of the endocannabinoid system","volume":"18","author":"Lisboa","year":"2015","journal-title":"Int. J. Neuropsychopharmacolog."},{"key":"2023072505495929600_B47","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00213-013-3211-9","article-title":"Medial prefrontal cortex transient receptor potential vanilloid type 1 (TRPV1) in the expression of contextual fear conditioning in Wistar rats","volume":"231","author":"Terzian","year":"2014","journal-title":"Psychopharmacology (Berl.)"},{"key":"2023072505495929600_B48","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1177\/0269881117691567","article-title":"N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: Role of the cannabinoid CB1 receptor in the dorsal hippocampus","volume":"31","author":"Gobira","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"2023072505495929600_B49","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrd1495","article-title":"The endocannabinoid system and its therapeutic exploitation","volume":"3","author":"Marzo","year":"2004","journal-title":"Nat. Rev. Drug Discovery"},{"key":"2023072505495929600_B50","doi-asserted-by":"publisher","first-page":"2470547019864096","DOI":"10.1177\/2470547019864096","article-title":"Endocannabinoid system alterations in posttraumatic stress disorder: a review of developmental and accumulative effects of trauma","volume":"3","author":"Bassir Nia","year":"2019","journal-title":"Chronic Stress"},{"key":"2023072505495929600_B51","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neubiorev.2016.12.033","article-title":"The endocannabinoid system as a target for novel anxiolytic drugs","volume":"76","author":"Patel","year":"2017","journal-title":"Neurosci. Biobehavioral Rev."},{"key":"2023072505495929600_B52","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.psyneuen.2009.03.013","article-title":"Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress","volume":"34","author":"Hill","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"2023072505495929600_B53","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/sj.mp.4001376","article-title":"Upregulation of CB1 receptors and agonist-stimulated [35S]GTP\u03b3S binding in the prefrontal cortex of depressed suicide victims","volume":"9","author":"Hungund","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"2023072505495929600_B54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2019.00138","article-title":"Effects of different stressors are modulated by different neurobiological systems: the role of GABA-A versus CB1 receptor gene variants in anxiety and depression","volume":"13","author":"Gonda","year":"2019","journal-title":"Front Cell Neurosci."},{"key":"2023072505495929600_B55","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00213-013-2995-y","article-title":"Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment","volume":"227","author":"Mitjans","year":"2013","journal-title":"Psychopharmacology (Berl.)"},{"key":"2023072505495929600_B56","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.euroneuro.2008.05.003","article-title":"Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression","volume":"18","author":"Domschke","year":"2008","journal-title":"Eur. Neuropsychopharmacol."},{"key":"2023072505495929600_B57","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1016\/S0140-6736(07)61721-8","article-title":"Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials","volume":"370","author":"Christensen","year":"2007","journal-title":"Lancet North Am. Ed."},{"key":"2023072505495929600_B58","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1007\/s00702-008-0131-7","article-title":"Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents","volume":"115","author":"Hill","year":"2008","journal-title":"J. Neural Transm."},{"key":"2023072505495929600_B59","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/mp.2013.61","article-title":"Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study","volume":"18","author":"Neumeister","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"2023072505495929600_B60","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/s41380-018-0215-1","article-title":"Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice","volume":"25","author":"Mayo","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"2023072505495929600_B61","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1002\/jnr.24860","article-title":"A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults","volume":"100","author":"Zabik","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"2023072505495929600_B62","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.euroneuro.2016.03.003","article-title":"Genetically reduced FAAH activity may be a risk for the development of anxiety and depression in persons with repetitive childhood trauma","volume":"26","author":"Lazary","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"2023072505495929600_B63","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.jad.2019.07.083","article-title":"A functional variant of CB2 receptor gene interacts with childhood trauma and FAAH gene on anxious and depressive phenotypes","volume":"257","author":"Lazary","year":"2019","journal-title":"J. Affect. Disord."},{"key":"2023072505495929600_B64","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.neubiorev.2021.11.040","article-title":"Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next?","volume":"132","author":"Ney","year":"2022","journal-title":"Neurosci. Biobehavioral Rev."},{"key":"2023072505495929600_B65","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00213-018-5127-x","article-title":"Tempering aversive\/traumatic memories with cannabinoids: a review of evidence from animal and human studies","volume":"236","author":"Lisboa","year":"2019","journal-title":"Psychopharmacology (Berl.)"},{"key":"2023072505495929600_B66","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/da.23170","article-title":"Cannabinoid polymorphisms interact with plasma endocannabinoid levels to predict fear extinction learning","volume":"38","author":"Ney","year":"2021","journal-title":"Depress. Anxiety"},{"key":"2023072505495929600_B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpsyt.2020.00315","article-title":"Endocannabinoid system components as potential biomarkers in psychiatry","volume":"11","author":"Navarrete","year":"2020","journal-title":"Front Psychiatry"},{"key":"2023072505495929600_B68","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.biopsych.2021.07.019","article-title":"Targeting the endocannabinoid system in the treatment of posttraumatic stress disorder: a promising case of preclinical-clinical translation?","volume":"91","author":"Mayo","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B69","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1046\/j.1460-9568.2002.02192.x","article-title":"The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety","volume":"16","author":"Haller","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"2023072505495929600_B70","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.euroneuro.2010.06.007","article-title":"Genes differentially expressed in CB1 knockout mice: Involvement in the depressive-like phenotype","volume":"21","author":"Aso","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"2023072505495929600_B71","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.neuroscience.2011.09.031","article-title":"CB1 receptor-deficient mice as a model for depression","volume":"204","author":"Valverde","year":"2012","journal-title":"Neuroscience"},{"key":"2023072505495929600_B72","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s00213-001-0946-5","article-title":"Involvement of CB1 cannabinoid receptors in emotional behaviour","volume":"159","author":"Martin","year":"2002","journal-title":"Psychopharmacology (Berl.)"},{"key":"2023072505495929600_B73","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200605000-00003","article-title":"The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice","volume":"17","author":"Mikics","year":"2006","journal-title":"Behav. Pharmacol."},{"key":"2023072505495929600_B74","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.nbd.2010.03.020","article-title":"Depression-like phenotype following chronic CB1 receptor antagonism","volume":"39","author":"Beyer","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"2023072505495929600_B75","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.pbb.2012.10.008","article-title":"Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability","volume":"103","author":"O'Brien","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"2023072505495929600_B76","first-page":"165","article-title":"Antidepressant\u2013like properties of ACEA (arachidonyl-2-chloroethylamide), the selective agonist of CB1 receptors","volume":"61","author":"Rutkowska","year":"2004","journal-title":"Acta Pol. Pharm."},{"key":"2023072505495929600_B77","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.euroneuro.2005.03.003","article-title":"Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test","volume":"15","author":"Hill","year":"2005","journal-title":"Eur. Neuropsychopharmacol."},{"key":"2023072505495929600_B78","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/01.fbp.0000135704.56422.40","article-title":"CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents","volume":"15","author":"Haller","year":"2004","journal-title":"Behav. Pharmacol."},{"key":"2023072505495929600_B79","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/j.psyneuen.2013.01.014","article-title":"Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit","volume":"38","author":"Ganon-Elazar","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"2023072505495929600_B80","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.bbr.2013.08.010","article-title":"Effects of endocannabinoid and endovanilloid systems on aversive memory extinction","volume":"256","author":"Laricchiuta","year":"2013","journal-title":"Behav. Brain Res."},{"key":"2023072505495929600_B81","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1177\/0269881110379507","article-title":"Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice","volume":"25","author":"Garc\u00eda-Guti\u00e9rrez","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"2023072505495929600_B82","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/j.1476-5381.2011.01625.x","article-title":"Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors","volume":"165","author":"Garc\u00eda-Guti\u00e9rrez","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"2023072505495929600_B83","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1111\/j.1476-5381.2010.00819.x","article-title":"Depression-resistant endophenotype in mice overexpressing cannabinoid CB(2) receptors","volume":"160","author":"Garc\u00eda-Guti\u00e9rrez","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"2023072505495929600_B84","doi-asserted-by":"publisher","first-page":"9817089","DOI":"10.1155\/2016\/9817089","article-title":"CB2 cannabinoid receptor knockout in mice impairs contextual long-term memory and enhances spatial working memory","volume":"2016","author":"Li","year":"2016","journal-title":"Neural Plast."},{"key":"2023072505495929600_B85","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1152\/jn.2001.85.1.468","article-title":"CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum","volume":"85","author":"Gerdeman","year":"2001","journal-title":"J. Neurophysiol."},{"key":"2023072505495929600_B86","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1017\/S1461145712000156","article-title":"The cannabinoid CB1 receptor biphasically modulates motor activity and regulates dopamine and glutamate release region dependently","volume":"16","author":"Polissidis","year":"2013","journal-title":"Int. J. Neuropsychopharmacolog."},{"key":"2023072505495929600_B87","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.neuint.2012.05.009","article-title":"Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release \u2013 Species differences","volume":"61","author":"Ferreira","year":"2012","journal-title":"Neurochem. Int."},{"key":"2023072505495929600_B88","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1038\/cdd.2015.11","article-title":"The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K\/Akt\/mTORC1\/BDNF pathway","volume":"22","author":"Bl\u00e1zquez","year":"2015","journal-title":"Cell Death Differentiation"},{"key":"2023072505495929600_B89","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/j.1471-4159.2007.05149.x","article-title":"BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice","volume":"105","author":"Aso","year":"2008","journal-title":"J. Neurochem."},{"key":"2023072505495929600_B90","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1111\/bph.12607","article-title":"Regulatory role of the cannabinoid CB2receptor in stress-induced neuroinflammation in mice","volume":"171","author":"Zoppi","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"2023072505495929600_B91","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00005","article-title":"Microglial cells as a link between cannabinoids and the immune hypothesis of psychiatric disorders","volume":"7","author":"Lisboa","year":"2016","journal-title":"Front Neurol."},{"key":"2023072505495929600_B92","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1038\/s41386-018-0064-2","article-title":"Repeated social defeat-induced neuroinflammation, anxiety-like behavior and resistance to fear extinction were attenuated by the cannabinoid receptor agonist WIN55,212-2","volume":"43","author":"Lisboa","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"2023072505495929600_B93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpsyt.2022.923177","article-title":"Inducible nitric oxide synthase inhibition in the medial prefrontal cortex attenuates the anxiogenic-like effect of acute restraint stress via CB1 receptors","volume":"13","author":"Coelho","year":"2022","journal-title":"Front Psychiatry"},{"key":"2023072505495929600_B94","doi-asserted-by":"publisher","first-page":"10506","DOI":"10.1523\/JNEUROSCI.0496-11.2011","article-title":"Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response","volume":"31","author":"Hill","year":"2011","journal-title":"J. Neurosci."},{"key":"2023072505495929600_B95","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrg.2017.80","article-title":"The DNA methyltransferase family: a versatile toolkit for epigenetic regulation","volume":"19","author":"Lyko","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"2023072505495929600_B96","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/978-1-4939-9554-7_33","article-title":"MeCP2 dysfunction in rett syndrome and neuropsychiatric disorders","volume":"2011","author":"Chin","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"2023072505495929600_B97","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.2217\/epi.15.39","article-title":"Methyl-CpG-binding domain proteins: readers of the epigenome","volume":"7","author":"Du","year":"2015","journal-title":"Epigenomics"},{"key":"2023072505495929600_B98","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1080\/15592294.2019.1638701","article-title":"DNA hypermethylation in disease: mechanisms and clinical relevance","volume":"14","author":"Ehrlich","year":"2019","journal-title":"Epigenetics"},{"key":"2023072505495929600_B99","doi-asserted-by":"publisher","first-page":"593","DOI":"10.2217\/epi.15.11","article-title":"Traumatic stress and human DNA methylation: a critical review","volume":"7","author":"Vinkers","year":"2015","journal-title":"Epigenomics"},{"key":"2023072505495929600_B100","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neuropharm.2014.01.013","article-title":"The role of DNA methylation in stress-related psychiatric disorders","volume":"80","author":"Klengel","year":"2014","journal-title":"Neuropharmacology"},{"key":"2023072505495929600_B101","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2217\/epi-2021-0190","article-title":"Evaluating the challenges and reproducibility of studies investigating DNA methylation signatures of psychological stress","volume":"14","author":"Zhang","year":"2022","journal-title":"Epigenomics"},{"key":"2023072505495929600_B102","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jpsychores.2016.11.005","article-title":"Stress, burnout and depression: A systematic review on DNA methylation mechanisms","volume":"92","author":"Bakusic","year":"2017","journal-title":"J. Psychosom. Res."},{"key":"2023072505495929600_B103","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.ebiom.2017.03.044","article-title":"Epigenetic pathways in human disease: the impact of DNA methylation on stress-related pathogenesis and current challenges in biomarker development","volume":"18","author":"Argentieri","year":"2017","journal-title":"EBioMedicine"},{"key":"2023072505495929600_B104","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/eat.22113","article-title":"Methylation of the glucocorticoid receptor gene promoter in bulimic women: Associations with borderline personality disorder, suicidality, and exposure to childhood abuse","volume":"46","author":"Steiger","year":"2013","journal-title":"Int. J. Eat. Disord."},{"key":"2023072505495929600_B105","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1001\/archgenpsychiatry.2011.2287","article-title":"Genome-wide epigenetic regulation by early-life trauma","volume":"69","author":"Labont\u00e9","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"2023072505495929600_B106","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.1038\/tp.2011.60","article-title":"Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma","volume":"1","author":"Perroud","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"2023072505495929600_B107","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1038\/tp.2011.21","article-title":"Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor","volume":"1","author":"Radtke","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"2023072505495929600_B108","doi-asserted-by":"publisher","first-page":"e30148","DOI":"10.1371\/journal.pone.0030148","article-title":"Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults","volume":"7","author":"Tyrka","year":"2012","journal-title":"PloS ONE"},{"key":"2023072505495929600_B109","doi-asserted-by":"publisher","first-page":"e368","DOI":"10.1038\/tp.2014.3","article-title":"Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder","volume":"4","author":"Labont\u00e9","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"2023072505495929600_B110","doi-asserted-by":"publisher","first-page":"10274","DOI":"10.1523\/JNEUROSCI.1526-14.2014","article-title":"Epigenetic modification of the glucocorticoid receptor gene is linked to traumatic memory and post-traumatic stress disorder risk in genocide survivors","volume":"34","author":"Vukojevic","year":"2014","journal-title":"J. Neurosci."},{"key":"2023072505495929600_B111","doi-asserted-by":"publisher","first-page":"e85425","DOI":"10.1371\/journal.pone.0085425","article-title":"Association between glucocorticoid receptor methylation and hippocampal subfields in major depressive disorder","volume":"9","author":"Na","year":"2014","journal-title":"PLoS ONE"},{"key":"2023072505495929600_B112","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.biopsych.2014.02.006","article-title":"Lower methylation of glucocorticoid receptor gene promoter 1F in Peripheral blood of veterans with posttraumatic stress disorder","volume":"77","author":"Yehuda","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B113","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nn.2270","article-title":"Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse","volume":"12","author":"McGowan","year":"2009","journal-title":"Nat. Neurosci."},{"key":"2023072505495929600_B114","doi-asserted-by":"publisher","first-page":"17266","DOI":"10.1073\/pnas.1121260109","article-title":"Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus","volume":"109","author":"Suderman","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023072505495929600_B115","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/ajmg.b.31028","article-title":"Methylation at SLC6A4 is linked to family history of child abuse: An examination of the Iowa Adoptee sample","volume":"153B","author":"Beach","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"2023072505495929600_B116","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/da.20825","article-title":"SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder","volume":"28","author":"Koenen","year":"2011","journal-title":"Depress. Anxiety"},{"key":"2023072505495929600_B117","doi-asserted-by":"publisher","first-page":"e45813","DOI":"10.1371\/journal.pone.0045813","article-title":"Environmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort","volume":"7","author":"Alasaari","year":"2012","journal-title":"PLoS ONE"},{"key":"2023072505495929600_B118","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pnpbp.2013.01.006","article-title":"Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression","volume":"44","author":"Kang","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"2023072505495929600_B119","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/PSY.0b013e3182924cf4","article-title":"Association between promoter methylation of serotonin transporter gene and depressive symptoms: A monozygotic twin study","volume":"75","author":"Zhao","year":"2013","journal-title":"Psychosom. Med."},{"key":"2023072505495929600_B120","doi-asserted-by":"publisher","first-page":"e39501","DOI":"10.1371\/journal.pone.0039501","article-title":"Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression","volume":"7","author":"Wang","year":"2012","journal-title":"PloS ONE"},{"key":"2023072505495929600_B121","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.jpsychires.2013.04.010","article-title":"A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression","volume":"47","author":"Kim","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"2023072505495929600_B122","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jpsychires.2014.02.002","article-title":"The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression","volume":"53","author":"Okada","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"2023072505495929600_B123","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-15-8104-5_1","article-title":"Overview of histone modification","volume-title":"Histone Mutations and Cancer","author":"Zhang","year":"2021"},{"key":"2023072505495929600_B124","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tig.2015.10.007","article-title":"Lateral thinking: how histone modifications regulate gene expression","volume":"32","author":"Lawrence","year":"2016","journal-title":"Trends Genet."},{"key":"2023072505495929600_B125","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1017\/S1461145711001520","article-title":"Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide","volume":"15","author":"Fiori","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"2023072505495929600_B126","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nm.3090","article-title":"Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression","volume":"19","author":"Golden","year":"2013","journal-title":"Nat. Med."},{"key":"2023072505495929600_B127","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1017\/S1461145712000363","article-title":"H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression","volume":"16","author":"Cruceanu","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"2023072505495929600_B128","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1177\/1073858415608147","article-title":"Epigenetic basis of mental illness","volume":"22","author":"Nestler","year":"2016","journal-title":"Neuroscientist: a Rev. J. Bringing Neurobiol. Neurol. Psychiatry"},{"key":"2023072505495929600_B129","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.neubiorev.2021.10.042","article-title":"Epigenetics of childhood trauma: Long term sequelae and potential for treatment","volume":"132","author":"Thumfart","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2023072505495929600_B130","doi-asserted-by":"crossref","first-page":"341","DOI":"10.31887\/DCNS.2019.21.4\/enestler","article-title":"Unraveling the epigenetic landscape of depression: focus on early life stress","volume":"21","author":"Torres-Berr\u00edo","year":"2019","journal-title":"Dialogues Clin. Neurosci."},{"key":"2023072505495929600_B131","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nn1659","article-title":"Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action","volume":"9","author":"Tsankova","year":"2006","journal-title":"Nat. Neurosci."},{"key":"2023072505495929600_B132","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.bbr.2013.08.041","article-title":"Ketamine and imipramine in the nucleus accumbens regulate histone deacetylation induced by maternal deprivation and are critical for associated behaviors","volume":"256","author":"R\u00e9us","year":"2013","journal-title":"Behav. Brain Res."},{"key":"2023072505495929600_B133","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejphar.2015.02.010","article-title":"Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms","volume":"752","author":"Nghia","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"2023072505495929600_B134","doi-asserted-by":"publisher","first-page":"8171","DOI":"10.1038\/srep08171","article-title":"An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine","volume":"5","author":"Schmauss","year":"2015","journal-title":"Sci. Rep."},{"key":"2023072505495929600_B135","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.neuropharm.2014.02.017","article-title":"Possible additional antidepressant-like mechanism of sodium butyrate: targeting the hippocampus","volume":"81","author":"Han","year":"2014","journal-title":"Neuropharmacology"},{"key":"2023072505495929600_B136","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1007\/s11064-021-03263-8","article-title":"SAHA improves depressive symptoms, cognitive impairment and oxidative stress: rise of a new antidepressant class","volume":"46","author":"Ershadi","year":"2021","journal-title":"Neurochem. Res."},{"key":"2023072505495929600_B137","doi-asserted-by":"publisher","first-page":"163140","DOI":"10.1155\/2015\/163140","article-title":"Histone deacetylase inhibitor trichostatin A ameliorated endotoxin-induced neuroinflammation and cognitive dysfunction","volume":"2015","author":"Hsing","year":"2015","journal-title":"Mediators Inflamm."},{"key":"2023072505495929600_B138","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.biopsych.2006.06.036","article-title":"Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse","volume":"62","author":"Schroeder","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B139","doi-asserted-by":"publisher","first-page":"194417","DOI":"10.1016\/j.bbagrm.2019.194417","article-title":"Non-coding RNA regulatory networks","volume":"1863","author":"Panni","year":"2020","journal-title":"Biochim. Biophys. Acta."},{"key":"2023072505495929600_B140","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/978-3-319-53889-1_11","article-title":"Noncoding RNAs in depression","volume-title":"Neuroepigenomics in Aging and Disease","author":"Lin","year":"2017"},{"key":"2023072505495929600_B141","first-page":"23","article-title":"MicroRNAs in post-traumatic stress disorder","volume-title":"Behavioral Neurobiology of PTSD","author":"Snijders","year":"2018"},{"key":"2023072505495929600_B142","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/7854_2019_118","article-title":"Role of MicroRNAs in anxiety and anxiety-related disorders","volume-title":"Behavioral Neurogenomics","author":"Murphy","year":"2019"},{"key":"2023072505495929600_B143","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.tips.2016.10.004","article-title":"All roads lead to the miRNome: miRNAs have a central role in the molecular pathophysiology of psychiatric disorders","volume":"37","author":"O'Connor","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"2023072505495929600_B144","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jad.2018.07.075","article-title":"MicroRNAs in depression and suicide: recent insights and future perspectives","volume":"240","author":"Dwivedi","year":"2018","journal-title":"J. Affect. Disord."},{"key":"2023072505495929600_B145","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells8070647","article-title":"Aberrant expression of intracellular let-7e, miR-146a, and miR-155 correlates with severity of depression in patients with major depressive disorder and is ameliorated after antidepressant treatment","volume":"8","author":"Hung","year":"2019","journal-title":"Cells"},{"key":"2023072505495929600_B146","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.euroneuro.2012.06.013","article-title":"Blood microRNA changes in depressed patients during antidepressant treatment","volume":"23","author":"Bocchio-Chiavetto","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"2023072505495929600_B147","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1126\/science.1193692","article-title":"miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants","volume":"329","author":"Baudry","year":"2010","journal-title":"Science"},{"key":"2023072505495929600_B148","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1080\/15592294.2016.1273308","article-title":"Mutual regulation of microRNAs and DNA methylation in human cancers","volume":"12","author":"Wang","year":"2017","journal-title":"Epigenetics"},{"key":"2023072505495929600_B149","doi-asserted-by":"publisher","first-page":"104603","DOI":"10.1016\/j.compbiomed.2021.104603","article-title":"Application of miRNA-seq in neuropsychiatry: a methodological perspective","volume":"135","author":"P\u00e9rez-Rodr\u00edguez","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"2023072505495929600_B150","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1159\/000338642","article-title":"CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence","volume":"19","author":"Rotter","year":"2013","journal-title":"Eur. Addict. Res."},{"key":"2023072505495929600_B151","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1093\/schbul\/sbt080","article-title":"Methylation patterns in whole blood correlate with symptoms in schizophrenia patients","volume":"40","author":"Liu","year":"2014","journal-title":"Schizophr. Bull."},{"key":"2023072505495929600_B152","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.biopsych.2011.06.027","article-title":"Maternal cannabis use alters ventral striatal dopamine D2 gene regulation in the offspring","volume":"70","author":"DiNieri","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B153","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.biopsych.2004.10.015","article-title":"In utero marijuana exposure associated with abnormal amygdala dopamine D2 gene expression in the human fetus","volume":"56","author":"Wang","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B154","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ijdevneu.2018.11.007","article-title":"Behavioural and epigenetic effects of paternal exposure to cannabinoids during adolescence on offspring vulnerability to stress","volume":"72","author":"Ibn Lahmar Andaloussi","year":"2019","journal-title":"Int. J. Dev. Neurosci."},{"key":"2023072505495929600_B155","doi-asserted-by":"publisher","first-page":"17034","DOI":"10.1038\/s41598-019-53579-3","article-title":"Paternal activation of CB2 cannabinoid receptor impairs placental and embryonic growth via an epigenetic mechanism","volume":"9","author":"Innocenzi","year":"2019","journal-title":"Sci. Rep."},{"key":"2023072505495929600_B156","doi-asserted-by":"publisher","first-page":"112627","DOI":"10.1016\/j.bbr.2020.112627","article-title":"CBD modulates DNA methylation in the prefrontal cortex and hippocampus of mice exposed to forced swim","volume":"388","author":"Sales","year":"2020","journal-title":"Behav. Brain Res."},{"key":"2023072505495929600_B157","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresbull.2018.01.014","article-title":"Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: Reversal by cannabidiol","volume":"139","author":"da Silva","year":"2018","journal-title":"Brain Res. Bull."},{"key":"2023072505495929600_B158","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1002\/em.22396","article-title":"Subacute cannabidiol alters genome-wide DNA methylation in adult mouse hippocampus","volume":"61","author":"Wanner","year":"2020","journal-title":"Environ. Mol. Mutagen."},{"key":"2023072505495929600_B159","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1126\/science.1190485","article-title":"Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes","volume":"329","author":"Wu","year":"2010","journal-title":"Science"},{"key":"2023072505495929600_B160","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1002\/jnr.23077","article-title":"Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells","volume":"90","author":"Wu","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"2023072505495929600_B161","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom10111575","article-title":"Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders","volume":"10","author":"Garc\u00eda-Guti\u00e9rrez","year":"2020","journal-title":"Biomolecules"},{"key":"2023072505495929600_B162","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.euroneuro.2016.12.004","article-title":"Interactions between cannabidiol and \u03949-THC following acute and repeated dosing: Rebound hyperactivity, sensorimotor gating and epigenetic and neuroadaptive changes in the mesolimbic pathway","volume":"27","author":"Todd","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"2023072505495929600_B163","doi-asserted-by":"publisher","first-page":"142","DOI":"10.2174\/1871524920666200924114524","article-title":"Effects on the post-translational modification of H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 levels in cerebral cortex, hypothalamus and pons of rats after a systemic administration of cannabidiol: a preliminary study","volume":"21","author":"Pastrana-Trejo","year":"2021","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"2023072505495929600_B164","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neuropharm.2016.10.008","article-title":"Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex","volume":"113","author":"Lomazzo","year":"2017","journal-title":"Neuropharmacology"},{"key":"2023072505495929600_B165","doi-asserted-by":"publisher","first-page":"e455","DOI":"10.1038\/emm.2017.289","article-title":"Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice","volume":"50","author":"Wang","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"2023072505495929600_B166","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.celrep.2017.03.050","article-title":"TRPV1 Regulates Stress Responses through HDAC2","volume":"19","author":"Wang","year":"2017","journal-title":"Cell Rep."},{"key":"2023072505495929600_B167","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neulet.2017.07.017","article-title":"Treatment with TREK1 and TRPC3\/6 ion channel inhibitors upregulates microRNA expression in a mouse model of chronic mild stress","volume":"656","author":"Buran","year":"2017","journal-title":"Neurosci. Lett."},{"key":"2023072505495929600_B168","doi-asserted-by":"publisher","first-page":"e184","DOI":"10.1038\/tp.2012.95","article-title":"Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder","volume":"2","author":"Lee","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"2023072505495929600_B169","first-page":"1","article-title":"Neurotrophin Bdnf and novel molecular targets in depression pathogenesis","volume":"1","author":"Numakawa","year":"2013","journal-title":"J. Neurol. Transl. Neurosci."},{"key":"2023072505495929600_B170","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1046\/j.1471-4159.2001.00300.x","article-title":"Reduced activation and expression of ERK1\/2 MAP kinase in the post-mortem brain of depressed suicide subjects","volume":"77","author":"Dwivedi","year":"2001","journal-title":"J. Neurochem."},{"key":"2023072505495929600_B171","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1038\/tp.2011.54","article-title":"Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16","volume":"1","author":"Launay","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"2023072505495929600_B172","doi-asserted-by":"publisher","first-page":"e46921","DOI":"10.1371\/journal.pone.0046921","article-title":"Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life","volume":"7","author":"Bai","year":"2012","journal-title":"PLoS ONE"},{"key":"2023072505495929600_B173","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neures.2007.10.010","article-title":"Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains","volume":"60","author":"Tochigi","year":"2008","journal-title":"Neurosci. Res."},{"key":"2023072505495929600_B174","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.jad.2011.10.030","article-title":"Genetic variation in the calcium\/calmodulin-dependent protein kinase (CaMK) pathway is associated with antidepressant response in females","volume":"136","author":"Shi","year":"2012","journal-title":"J. Affect. Disord."},{"key":"2023072505495929600_B175","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms232416101","article-title":"FAAH Inhibition restores early life stress-induced alterations in PFC microRNAs associated with depressive-like behavior in male and female rats","volume":"23","author":"Portugalov","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2023072505495929600_B176","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neuropharm.2016.05.007","article-title":"MicroRNA let-7d is a target of cannabinoid CB1 receptor and controls cannabinoid signaling","volume":"108","author":"Chiarlone","year":"2016","journal-title":"Neuropharmacology"},{"key":"2023072505495929600_B177","doi-asserted-by":"publisher","first-page":"e869","DOI":"10.1038\/tp.2016.136","article-title":"Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression","volume":"6","author":"Wei","year":"2016","journal-title":"Translational Psychiatry"},{"key":"2023072505495929600_B178","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1016\/j.euroneuro.2018.09.004","article-title":"Lentiviral-mediated let-7d microRNA overexpression induced anxiolytic- and anti-depressant-like behaviors and impaired dopamine D3 receptor expression","volume":"28","author":"Bahi","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"2023072505495929600_B179","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1038\/srep01329","article-title":"MicroRNA let-7d regulates the TLX\/microRNA-9 cascade to control neural cell fate and neurogenesis","volume":"3","author":"Zhao","year":"2013","journal-title":"Sci. Rep."},{"key":"2023072505495929600_B180","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.mcn.2009.08.009","article-title":"microRNAs miR-124, let-7d and miR-181a regulate Cocaine-induced Plasticity","volume":"42","author":"Chandrasekar","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"2023072505495929600_B181","doi-asserted-by":"publisher","first-page":"657","DOI":"10.2217\/epi-2020-0037","article-title":"Epigenetic fragility of the endocannabinoid system under stress: risk for mood disorders and pharmacogenomic implications","volume":"12","author":"Ferber","year":"2020","journal-title":"Epigenomics"},{"key":"2023072505495929600_B182","doi-asserted-by":"publisher","first-page":"9995","DOI":"10.1021\/acsomega.2c00635","article-title":"Interplay between the cannabinoid system and microRNAs in cancer","volume":"7","author":"Salamat","year":"2022","journal-title":"ACS Omega"},{"key":"2023072505495929600_B183","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031113","article-title":"The epigenetics of the endocannabinoid system","volume":"21","author":"Meccariello","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2023072505495929600_B184","doi-asserted-by":"publisher","first-page":"105237","DOI":"10.1016\/j.phrs.2020.105237","article-title":"Epigenetics and the endocannabinoid system signaling: An intricate interplay modulating neurodevelopment","volume":"162","author":"Gomes","year":"2020","journal-title":"Pharmacol. Res."},{"key":"2023072505495929600_B185","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41398-020-0832-8","article-title":"Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia","volume":"10","author":"Tao","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"2023072505495929600_B186","doi-asserted-by":"publisher","first-page":"6468","DOI":"10.1158\/0008-5472.CAN-08-0896","article-title":"Loss of cannabinoid receptor 1 accelerates intestinal tumor growth","volume":"68","author":"Wang","year":"2008","journal-title":"Cancer Res."},{"key":"2023072505495929600_B187","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nm.2608","article-title":"Prostaglandin E2 promotes intestinal tumor growth via DNA methylation","volume":"18","author":"Xia","year":"2012","journal-title":"Nat. Med."},{"key":"2023072505495929600_B188","doi-asserted-by":"publisher","first-page":"148.e7","DOI":"10.1053\/j.gastro.2014.09.032","article-title":"Epigenetic regulation of genes that modulate chronic stress-induced visceral pain in the peripheral nervous system","volume":"148","author":"Hong","year":"2015","journal-title":"Gastroenterology"},{"key":"2023072505495929600_B189","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.schres.2017.01.022","article-title":"A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia","volume":"188","author":"D'Addario","year":"2017","journal-title":"Schizophr. Res."},{"key":"2023072505495929600_B190","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3389\/fgene.2019.00523","article-title":"Preclinical and clinical evidence for a distinct regulation of Mu opioid and Type 1 cannabinoid receptor genes expression in obesity","volume":"10","author":"Pucci","year":"2019","journal-title":"Front. Genet."},{"key":"2023072505495929600_B191","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1038\/npp.2015.129","article-title":"Epigenetic and proteomic expression changes promoted by eating addictive-like behavior","volume":"40","author":"Mancino","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"2023072505495929600_B192","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jnutbio.2014.10.013","article-title":"Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms","volume":"26","author":"Di Francesco","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"2023072505495929600_B193","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/eat.23271","article-title":"Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa","volume":"53","author":"D'Addario","year":"2020","journal-title":"Int. J. Eat. Disord."},{"key":"2023072505495929600_B194","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000331474","article-title":"Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-Aza-2\u2032-deoxycytidine","volume":"19","author":"B\u00f6rner","year":"2012","journal-title":"NeuroImmunoModulation"},{"key":"2023072505495929600_B195","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3389\/fpsyt.2018.00594","article-title":"Opposite Epigenetic associations with alcohol use and exercise intervention","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Psychiatry"},{"key":"2023072505495929600_B196","doi-asserted-by":"publisher","first-page":"e39186","DOI":"10.1371\/journal.pone.0039186","article-title":"Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease","volume":"7","author":"D'Addario","year":"2012","journal-title":"PLoS ONE"},{"key":"2023072505495929600_B197","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.biopsych.2010.05.036","article-title":"Epigenetic transmission of the impact of early stress across generations","volume":"68","author":"Franklin","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B198","doi-asserted-by":"publisher","first-page":"9470","DOI":"10.1073\/pnas.0910794107","article-title":"Epigenetic and immune function profiles associated with posttraumatic stress disorder","volume":"107","author":"Uddin","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023072505495929600_B199","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/npp.2017.162","article-title":"Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder","volume":"43","author":"Hill","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"2023072505495929600_B200","doi-asserted-by":"publisher","first-page":"pyu028","DOI":"10.1093\/ijnp\/pyu028","article-title":"Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice","volume":"18","author":"Subbanna","year":"2015","journal-title":"Int. J. Neuropsychopharmacolog."},{"key":"2023072505495929600_B201","doi-asserted-by":"publisher","first-page":"6350","DOI":"10.1523\/JNEUROSCI.3786-12.2013","article-title":"Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits","volume":"33","author":"Subbanna","year":"2013","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"2023072505495929600_B202","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1074\/jbc.RA119.011053","article-title":"Histone methyltransferase G9a diminishes expression of cannabinoid CB1 receptors in primary sensory neurons in neuropathic pain","volume":"295","author":"Luo","year":"2020","journal-title":"J. Biol. Chem."},{"key":"2023072505495929600_B203","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/eat.22989","article-title":"Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene","volume":"52","author":"Pucci","year":"2019","journal-title":"Int. J. Eat. Disord."},{"key":"2023072505495929600_B204","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24020264","article-title":"MicroRNA-29a attenuates diabetic glomerular injury through modulating cannabinoid receptor 1 signaling","volume":"24","author":"Tung","year":"2019","journal-title":"Molecules"},{"key":"2023072505495929600_B205","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1007\/s00381-016-3243-7","article-title":"Spontaneous involution of pediatric low-grade gliomas: high expression of cannabinoid receptor 1 (CNR1) at the time of diagnosis may indicate involvement of the endocannabinoid system","volume":"32","author":"Sredni","year":"2016","journal-title":"Childs Nervous System"},{"key":"2023072505495929600_B206","doi-asserted-by":"publisher","first-page":"104545","DOI":"10.1016\/j.yexmp.2020.104545","article-title":"Neuro-protective roles of long non-coding RNA MALAT1 in Alzheimer's disease with the involvement of the microRNA-30b\/CNR1 network and the following PI3K\/AKT activation","volume":"117","author":"Li","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"2023072505495929600_B207","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12967-020-02406-9","article-title":"microRNA-128 mediates CB1 expression and regulates NF-KB\/p-JNK axis to influence the occurrence of diabetic bladder disease","volume":"18","author":"Gou","year":"2020","journal-title":"J. Transl. Med."},{"key":"2023072505495929600_B208","doi-asserted-by":"publisher","first-page":"136124","DOI":"10.1016\/j.neulet.2021.136124","article-title":"Overexpression of miR-338-5p in exosomes derived from mesenchymal stromal cells provides neuroprotective effects by the Cnr1\/Rap1\/Akt pathway after spinal cord injury in rats","volume":"761","author":"Zhang","year":"2021","journal-title":"Neurosci. Lett."},{"key":"2023072505495929600_B209","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.bbrc.2014.08.008","article-title":"MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure","volume":"451","author":"M\u00f6hnle","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072505495929600_B210","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.diff.2019.07.002","article-title":"Inhibiting effect of microRNA-187-3p on osteogenic differentiation of osteoblast precursor cells by suppressing cannabinoid receptor type 2","volume":"109","author":"Xu","year":"2019","journal-title":"Differentiation"},{"key":"2023072505495929600_B211","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/adb.12625","article-title":"Silencing synaptic MicroRNA-411 reduces voluntary alcohol consumption in mice","volume":"24","author":"Most","year":"2019","journal-title":"Addict. Biol."},{"key":"2023072505495929600_B212","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/s41398-021-01588-0","article-title":"miR-98-5p plays a critical role in depression and antidepressant effect of ketamine","volume":"11","author":"Huang","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"2023072505495929600_B213","doi-asserted-by":"publisher","first-page":"15007","DOI":"10.1523\/JNEUROSCI.1436-10.2010","article-title":"Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents","volume":"30","author":"Uchida","year":"2010","journal-title":"J. Neurosci."},{"key":"2023072505495929600_B214","doi-asserted-by":"publisher","first-page":"1987655","DOI":"10.1080\/20008198.2021.1987655","article-title":"Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients","volume":"12","author":"Maffioletti","year":"2021","journal-title":"Eur. J. Psychotraumatol."},{"key":"2023072505495929600_B215","doi-asserted-by":"publisher","first-page":"e75960","DOI":"10.1371\/journal.pone.0075960","article-title":"Chronic academic stress increases a group of microRNAs in peripheral blood","volume":"8","author":"Honda","year":"2013","journal-title":"PLoS ONE"},{"key":"2023072505495929600_B216","doi-asserted-by":"publisher","first-page":"e0209846","DOI":"10.1371\/journal.pone.0209846","article-title":"Bioinformatic analysis of long-lasting transcriptional and translational changes in the basolateral amygdala following acute stress","volume":"14","author":"Sillivan","year":"2019","journal-title":"PLoS ONE"},{"key":"2023072505495929600_B217","doi-asserted-by":"publisher","first-page":"e0121975","DOI":"10.1371\/journal.pone.0121975","article-title":"Identification of differential microRNAs in cerebrospinal fluid and serum of patients with major depressive disorder","volume":"10","author":"Wan","year":"2015","journal-title":"PLoS ONE"},{"key":"2023072505495929600_B218","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0164-4","article-title":"Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats","volume":"50","author":"Wan","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"2023072505495929600_B219","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.bbr.2009.11.012","article-title":"Stress induces region specific alterations in microRNAs expression in mice","volume":"208","author":"Rinaldi","year":"2010","journal-title":"Behav. Brain Res."},{"key":"2023072505495929600_B220","doi-asserted-by":"publisher","first-page":"e24682","DOI":"10.1371\/journal.pone.0024682","article-title":"NMDA mediated contextual conditioning changes miRNA expression","volume":"6","author":"Kye","year":"2011","journal-title":"PLoS ONE"},{"key":"2023072505495929600_B221","doi-asserted-by":"publisher","first-page":"3924","DOI":"10.1038\/s41467-019-11876-5","article-title":"Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors","volume":"10","author":"Gorinski","year":"2019","journal-title":"Nat. Commun."},{"key":"2023072505495929600_B222","doi-asserted-by":"publisher","first-page":"e1160","DOI":"10.1038\/tp.2017.122","article-title":"Inflammation and vascular remodeling in the ventral hippocampus contributes to vulnerability to stress","volume":"7","author":"Pearson-Leary","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"2023072505495929600_B223","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s00213-019-05209-z","article-title":"microRNA and mRNA profiles in the amygdala are associated with stress-induced depression and resilience in juvenile mice","volume":"236","author":"Shen","year":"2019","journal-title":"Psychopharmacology (Berl.)"},{"key":"2023072505495929600_B224","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.psychres.2017.01.081","article-title":"Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans","volume":"251","author":"Martin","year":"2017","journal-title":"Psychiatry Res."},{"key":"2023072505495929600_B225","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/ijnp\/pyz071","article-title":"Amygdala-based altered miRNome and epigenetic contribution of miR-128-3p in conferring susceptibility to depression-like behavior via Wnt signaling","volume":"23","author":"Roy","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"2023072505495929600_B226","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1038\/nn.2891","article-title":"The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory","volume":"14","author":"Lin","year":"2011","journal-title":"Nat. Neurosci."},{"key":"2023072505495929600_B227","doi-asserted-by":"publisher","first-page":"e33201","DOI":"10.1371\/journal.pone.0033201","article-title":"MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects","volume":"7","author":"Smalheiser","year":"2012","journal-title":"PloS ONE"},{"key":"2023072505495929600_B228","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.pnpbp.2018.05.023","article-title":"microRNA and mRNA profiles in ventral tegmental area relevant to stress-induced depression and resilience","volume":"86","author":"Sun","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"2023072505495929600_B229","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1007\/s00213-020-05593-x","article-title":"Revision to psychopharmacology mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex","volume":"237","author":"Yang","year":"2020","journal-title":"Psychopharmacology (Berl.)"},{"key":"2023072505495929600_B230","doi-asserted-by":"publisher","first-page":"3000605211006633","DOI":"10.1177\/03000605211006633","article-title":"Distribution of microRNAs associated with major depressive disorder among blood compartments","volume":"49","author":"Homorogan","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"2023072505495929600_B231","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.biopsych.2015.10.028","article-title":"The potential role of amygdaloid microRNA-494 in alcohol-induced anxiolysis","volume":"80","author":"Teppen","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B232","doi-asserted-by":"publisher","first-page":"e185","DOI":"10.1038\/tp.2012.112","article-title":"Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode","volume":"2","author":"Belzeaux","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"2023072505495929600_B233","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jpsychires.2014.05.020","article-title":"Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential","volume":"57","author":"Balakathiresan","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"2023072505495929600_B234","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms22179439","article-title":"MicroRNA Let-7e in the mouse prefrontal cortex differentiates restraint-stress-resilient genotypes from susceptible genotype","volume":"22","author":"Solich","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2023072505495929600_B235","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jad.2016.04.021","article-title":"Peripheral whole blood microRNA alterations in major depression and bipolar disorder","volume":"200","author":"Maffioletti","year":"2016","journal-title":"J. Affect. Disord."},{"key":"2023072505495929600_B236","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105157","article-title":"Dysregulation of miR-15a-5p, miR-497a-5p and miR-511-5p is associated with modulation of BDNF and FKBP5 in brain areas of PTSD-related susceptible and resilient mice","volume":"22","author":"Maurel","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2023072505495929600_B237","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1097\/WNR.0000000000001484","article-title":"miR-187-3p participates in contextual fear memory formation through modulating SATB2 expression in the hippocampus","volume":"31","author":"Zhao","year":"2020","journal-title":"Neuroreport"},{"key":"2023072505495929600_B238","doi-asserted-by":"publisher","first-page":"778170","DOI":"10.3389\/fnmol.2021.778170","article-title":"Identification of the similarities and differences of molecular networks associated with fear memory formation, extinction, and updating in the amygdala","volume":"14","author":"Su","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"2023072505495929600_B239","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1186\/s12864-021-08003-4","article-title":"Early life and adult stress promote sex dependent changes in hypothalamic miRNAs and environmental enrichment prevents stress-induced miRNA and gene expression changes in rats","volume":"22","author":"McKibben","year":"2021","journal-title":"BMC Genomics"},{"key":"2023072505495929600_B240","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.2217\/epi-2021-0037","article-title":"Early-life stress induces genome-wide sex-dependent miRNA expression and correlation across limbic brain areas in rats","volume":"13","author":"McKibben","year":"2021","journal-title":"Epigenomics"},{"key":"2023072505495929600_B241","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/npp.2014.176","article-title":"Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus","volume":"40","author":"Patr\u00edcio","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"2023072505495929600_B242","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1523\/JNEUROSCI.3732-09.2010","article-title":"Histone methylation regulates memory formation","volume":"30","author":"Gupta","year":"2010","journal-title":"J. Neurosci.:Off. J. Soc. Neurosci."},{"key":"2023072505495929600_B243","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/npp.2012.86","article-title":"The role of histone acetylation in memory formation and cognitive impairments","volume":"38","author":"Peixoto","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"2023072505495929600_B244","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.jpsychires.2013.05.028","article-title":"Antidepressants and mood stabilizers effects on histone deacetylase expression in C57BL\/6 mice: Brain region specific changes","volume":"47","author":"Ookubo","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"2023072505495929600_B245","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.bcp.2018.09.013","article-title":"Role of the endocannabinoid system in drug addiction","volume":"157","author":"Manzanares","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"2023072505495929600_B246","doi-asserted-by":"publisher","first-page":"03","DOI":"10.35946\/arcr.v42.1.03","article-title":"The synaptic interactions of alcohol and the endogenous cannabinoid system","volume":"42","author":"Wolfe","year":"2022","journal-title":"Alcohol Res.: Curr. Rev."},{"key":"2023072505495929600_B247","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/neu.2022.23","article-title":"Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses","author":"Gobira","year":"2022","journal-title":"Acta Neuropsychiatrica"},{"key":"2023072505495929600_B248","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/npp.2015.142","article-title":"Stress-induced reinstatement of drug seeking: 20 years of progress","volume":"41","author":"Mantsch","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"2023072505495929600_B249","doi-asserted-by":"publisher","first-page":"108567","DOI":"10.1016\/j.neuropharm.2021.108567","article-title":"Effect of early life social adversity on drug abuse vulnerability: focus on corticotropin-releasing factor and oxytocin","volume":"191","author":"Bardo","year":"2021","journal-title":"Neuropharmacology"},{"key":"2023072505495929600_B250","doi-asserted-by":"publisher","first-page":"12199","DOI":"10.1038\/ncomms12199","article-title":"Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons","volume":"7","author":"Tung","year":"2016","journal-title":"Nat. Commun."},{"key":"2023072505495929600_B251","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.biopsych.2017.09.024","article-title":"Stress promotes drug seeking through glucocorticoid-dependent endocannabinoid mobilization in the prelimbic cortex","volume":"84","author":"McReynolds","year":"2018","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"2023072505495929600_B252","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1196\/annals.1441.030","article-title":"Chronic Stress, Drug Use, and Vulnerability to Addiction","volume":"1141","author":"Sinha","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"key":"2023072505495929600_B253","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1007\/s12035-022-02722-9","article-title":"Hippocampal cannabinoid 1 receptors are modulated following cocaine self-administration in male rats","volume":"59","author":"De Sa Nogueira","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"2023072505495929600_B254","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ijnp\/pyu028","article-title":"Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice","volume":"18","author":"Subbanna","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"2023072505495929600_B255","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/jnc.13006","article-title":"CB1-receptor knockout neonatal mice are protected against ethanol-induced impairments of DNMT1, DNMT3A, and DNA methylation","volume":"132","author":"Nagre","year":"2015","journal-title":"J. Neurochem."},{"key":"2023072505495929600_B256","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/ijnp\/pyaa017","article-title":"Postnatal ethanol exposure activates HDAC-mediated histone deacetylation, impairs synaptic plasticity gene expression and behavior in mice","volume":"23","author":"Shivakumar","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"2023072505495929600_B257","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3389\/fnmol.2018.00045","article-title":"CB1R-mediated activation of caspase-3 causes epigenetic and neurobehavioral abnormalities in postnatal ethanol-exposed mice","volume":"11","author":"Subbanna","year":"2018","journal-title":"Front Mol. Neurosci."},{"key":"2023072505495929600_B258","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1868-7083-5-14","article-title":"Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders","volume":"5","author":"Stringer","year":"2013","journal-title":"Clin. Epigenetics"},{"key":"2023072505495929600_B259","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.neubiorev.2017.05.011","article-title":"High times for cannabis: Epigenetic imprint and its legacy on brain and behavior","volume":"85","author":"Szutorisz","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2023072505495929600_B260","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.biopsych.2012.04.026","article-title":"Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability","volume":"72","author":"Tomasiewicz","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"2023072505495929600_B261","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102094","article-title":"Chronic \u03948-THC exposure differently affects histone modifications in the adolescent and adult rat brain","volume":"18","author":"Prini","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"2023072505495929600_B262","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1503\/jpn.170082","article-title":"Adolescent THC exposure in female rats leads to cognitive deficits through a mechanism involving chromatin modifications in the prefrontal cortex","volume":"43","author":"Prini","year":"2018","journal-title":"J. Psychiatry Neurosci.:JPN"},{"key":"2023072505495929600_B263","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1038\/npp.2015.155","article-title":"Genome-wide DNA methylation profiling reveals epigenetic changes in the rat nucleus accumbens associated with cross-generational effects of adolescent THC exposure","volume":"40","author":"Watson","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"2023072505495929600_B264","doi-asserted-by":"publisher","first-page":"106806","DOI":"10.1016\/j.ntt.2019.04.003","article-title":"Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring","volume":"74","author":"Levin","year":"2019","journal-title":"Neurotoxicol. Teratol."},{"key":"2023072505495929600_B265","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1080\/15592294.2018.1554521","article-title":"Cannabinoid exposure and altered DNA methylation in rat and human sperm","volume":"13","author":"Murphy","year":"2018","journal-title":"Epigenetics"},{"key":"2023072505495929600_B266","doi-asserted-by":"publisher","first-page":"16022","DOI":"10.1038\/s41598-020-72783-0","article-title":"Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin","volume":"10","author":"Schrott","year":"2020","journal-title":"Sci. Rep."},{"key":"2023072505495929600_B267","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1080\/19396368.2022.2073292","article-title":"Cannabis alters DNA methylation at maternally imprinted and autism candidate genes in spermatogenic cells","volume":"68","author":"Schrott","year":"2022","journal-title":"Systems Biol. Reproduct. Med."},{"key":"2023072505495929600_B268","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1111\/febs.12125","article-title":"Epigenetic mechanisms and endocannabinoid signalling","volume":"280","author":"D'Addario","year":"2013","journal-title":"FEBS J."},{"key":"2023072505495929600_B269","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21176252","article-title":"Endocannabinoid-epigenetic cross-talk: a bridge toward stress coping","volume":"21","author":"Rusconi","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Neuronal Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/neuronalsignal\/article-pdf\/doi\/10.1042\/NS20220034\/948429\/ns-2022-0034c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/neuronalsignal\/article-pdf\/doi\/10.1042\/NS20220034\/948429\/ns-2022-0034c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:50:37Z","timestamp":1690249837000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/neuronalsignal\/article\/7\/2\/NS20220034\/233276\/Endocannabinoid-signaling-and-epigenetics"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":269,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,7,26]]}},"URL":"https:\/\/doi.org\/10.1042\/ns20220034","relation":{},"ISSN":["2059-6553"],"issn-type":[{"value":"2059-6553","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7]]},"published":{"date-parts":[[2023,7]]},"article-number":"NS20220034"}}