{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:24:02Z","timestamp":1769235842074,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1969,6,1]]},"abstract":"<jats:p>1. 14C from [1\u221214C]glucose injected intraperitoneally into mice is incorporated into glutamate, aspartate and glutamine in the brain to a much greater extent than 14C from [2\u221214C]glucose. This difference for [1\u221214C]glucose and [2\u221214C]glucose increases with time. The amount of 14C in C-1 of glutamate increases steadily with time with both precursors. It is suggested that a large part of the glutamate and aspartate pools in brain are in close contact with intermediates of a fast-turning tricarboxylic acid cycle. 2. 14C from [1\u221214C]acetate and [2\u221214C]acetate is incorporated to a much larger extent into glutamine than into glutamate. An examination of the time-course of 14C incorporated into glutamine and glutamate reveals that glutamine is not formed from the glutamate pool, labelled extensively by glucose, but from a small glutamate pool. This small glutamate pool is not derived from an intermediate of a fast-turning tricarboxylic acid cycle. 3. It is proposed that two different tricarboxylic acid cycles exist in brain.<\/jats:p>","DOI":"10.1042\/bj1130281","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T21:37:25Z","timestamp":1439501845000},"page":"281-290","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["Compartmentation of glutamate metabolism in brain. Evidence for the existence of two different tricarboxylic acid cycles in brain"],"prefix":"10.1042","volume":"113","author":[{"given":"C. J.","family":"Van Den Berg","sequence":"first","affiliation":[{"name":"New York State Psychiatric Institute and Department of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LJ.","family":"Kr\u017eali\u0107","sequence":"additional","affiliation":[{"name":"New York State Psychiatric Institute and Department of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mela","sequence":"additional","affiliation":[{"name":"New York State Psychiatric Institute and Department of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Waelsch","sequence":"additional","affiliation":[{"name":"New York State Psychiatric Institute and Department of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/113\/2\/281\/763816\/bj1130281.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/113\/2\/281\/763816\/bj1130281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T21:25:12Z","timestamp":1638221112000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/113\/2\/281\/16724\/Compartmentation-of-glutamate-metabolism-in-brain"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,6,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1969,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1130281","relation":{},"ISSN":["0306-3283"],"issn-type":[{"value":"0306-3283","type":"print"}],"subject":[],"published":{"date-parts":[[1969,6,1]]}}}