{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:47:11Z","timestamp":1766267231853},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,12,1]]},"abstract":"<jats:p>1. The extent of ethylation of N-7 of guanine in the nucleic acids of rat tissue in vivo by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate was measured. 2. All compounds produced measurable amounts of 7-ethyl-guanine. 3. A single dose of diethylnitrosamine or N-ethyl-N-nitrosourea produced tumours of the kidney in the rat. Three doses of ethyl methanesulphonate produced kidney tumours, but a single dose did not. 4. A single dose of diethylnitrosamine produced twice as much ethylation of N-7 of guanine in DNA of kidney as did N-ethyl-N-nitrosourea. A single dose of both compounds induced kidney tumours, although of a different histological type. 5. A single dose of ethyl methanesulphonate produced ten times as much ethylation of N-7 of guanine in kidney DNA as did N-ethyl-N-nitrosourea without producing tumours. 6. The relevance of these findings to the hypothesis that alkylation of a cellular component is the mechanism of induction of tumours by nitroso compounds is discussed.<\/jats:p>","DOI":"10.1042\/bj1250841","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T21:39:23Z","timestamp":1439501963000},"page":"841-847","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, <i>N<\/i>-ethyl-<i>N<\/i>-nitrosourea and ethyl methanesulphonate"],"prefix":"10.1042","volume":"125","author":[{"given":"P. F.","family":"Swann","sequence":"first","affiliation":[{"name":"S. A. Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, Riding House Street, London W1P 5PR, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. N.","family":"Magee","sequence":"additional","affiliation":[{"name":"S. A. Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, Riding House Street, London W1P 5PR, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/125\/3\/841\/774108\/bj1250841.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/125\/3\/841\/774108\/bj1250841.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T19:52:08Z","timestamp":1637956328000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/125\/3\/841\/19969\/Nitrosamine-induced-carcinogenesis-The-alkylation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,12,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1971,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1250841","relation":{},"ISSN":["0306-3283"],"issn-type":[{"value":"0306-3283","type":"print"}],"subject":[],"published":{"date-parts":[[1971,12,1]]}}}