{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:49:59Z","timestamp":1772106599740,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,6,1]]},"abstract":"<jats:p>1. 2-Deoxy-2-fluoro-d-glucose, 2-deoxy-2-fluoro-d-mannose and 2-deoxy-2,2-difluoro-d-arabino-hexose are good substrates for yeast hexokinase. 2. 3-Deoxy-3-fluoro-d-glucose and 4-deoxy-4-fluoro-d-glucose are poor substrates and have very similar Km values (8\u00d710\u22122m). 3. Neither \u03b1- nor \u03b2-d-glucopyranosyl fluoride is a substrate or inhibitor. 4. Studies with 2-chloro-2-deoxy- and 2-O-methyl derivatives of d-glucose and d-mannose have revealed that little chemical modification is possible at position 2 without substantial loss in substrate binding. 5. The variation in the value of Km for the d-hexose derivatives was associated with a corresponding change in the value of Km for MgATP2\u2212 showing that the binding of MgATP2\u2212 is modified by the binding of the sugar.<\/jats:p>","DOI":"10.1042\/bj1280199","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T19:44:32Z","timestamp":1439235872000},"page":"199-204","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["The use of deoxyfluoro-<scp>d<\/scp>-glucopyranoses and related compounds in a study of yeast hexokinase specificity"],"prefix":"10.1042","volume":"128","author":[{"given":"E. M.","family":"Bessell","sequence":"first","affiliation":[{"name":"Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London S.W.3, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"Foster","sequence":"additional","affiliation":[{"name":"Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London S.W.3, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Westwood","sequence":"additional","affiliation":[{"name":"Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London S.W.3, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/128\/2\/199\/777209\/bj1280199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/128\/2\/199\/777209\/bj1280199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T14:31:12Z","timestamp":1637937072000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/128\/2\/199\/6631\/The-use-of-deoxyfluoro-d-glucopyranoses-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,6,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1280199","relation":{},"ISSN":["0306-3283"],"issn-type":[{"value":"0306-3283","type":"print"}],"subject":[],"published":{"date-parts":[[1972,6,1]]}}}