{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:52:25Z","timestamp":1756993945050},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,2,1]]},"abstract":"<jats:p>Nuclear acidic proteins isolated from rat brain, heart, kidney and liver showed similar, complex patterns on electrophoresis in sodium dodecyl sulphate\u2013polyacrylamide gels. The contamination of nuclear acidic proteins by nuclear-membrane acidic proteins was found to the extent of 11%. Incorporation of [3H]acetate into the various nuclear acidic proteins in vivo, which were fractionated by polyacrylamide-gel electrophoresis, differed from tissue to tissue. Hydrolysis of these acetylated nuclear acidic proteins with 6m-HCl at 110\u00b0C released 70% of the radioactivity, which indicated that labile acetyl groups had been incorporated into these proteins. Analysis of [3H]acetate-labelled nuclear acidic proteins revealed two acetylated amino acid residues, N2-acetylserine and N2-acetyl-lysine. The significance of the role played by nuclear acidic proteins in relation to gene regulation is discussed.<\/jats:p>","DOI":"10.1042\/bj1370355","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T19:52:10Z","timestamp":1439236330000},"page":"355-362","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Isolation of nuclear acidic proteins from rat tissues. Characterization of acetylated liver nuclear acidic proteins"],"prefix":"10.1042","volume":"137","author":[{"given":"D.","family":"Suria","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Banting Institute, University of Toronto, Toronto, Ont. M5G 1L5, Canada"}]},{"given":"C. C.","family":"Liew","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Banting Institute, University of Toronto, Toronto, Ont. M5G 1L5, Canada"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/137\/2\/355\/562026\/bj1370355.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/137\/2\/355\/562026\/bj1370355.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T16:00:07Z","timestamp":1637942407000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/137\/2\/355\/9026\/Isolation-of-nuclear-acidic-proteins-from-rat"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1370355","relation":{},"ISSN":["0264-6021"],"issn-type":[{"value":"0264-6021","type":"print"}],"subject":[],"published":{"date-parts":[[1974,2,1]]}}}