{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:34:29Z","timestamp":1782502469412,"version":"3.54.5"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,3,1]]},"abstract":"<jats:p>The methods of Chou &amp; Fasman [Biochemistry (1974) 13, 211-222, 222-245] and of Lim [J. Mol. Biol. (1974)88, 857-872, 873-894] for predicting secondary structure from amino acid sequence have been applied to five predominantly helical membrane-associated peptides. The predictions from the method of Lim (1974a,b) are consistent with the experimental observations, whereas those from Chou &amp; Fasman (1974a,b), although not inconsistent with \u03b1-helix, favour a \u03b2-structure for several very hydrophobic regions. The results may be rationalized in terms of the effect of the solvent on the conformation of a polypeptide.<\/jats:p>","DOI":"10.1042\/bj1530729","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T20:02:18Z","timestamp":1439236938000},"page":"729-732","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The prediction of the conformation of membrane proteins from the sequence of amino acids"],"prefix":"10.1042","volume":"153","author":[{"given":"N M","family":"Green","sequence":"first","affiliation":[{"name":"National Institute for Medical Research, Mill Hill, London NW7 IAA, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Flanagan","sequence":"additional","affiliation":[{"name":"National Institute for Medical Research, Mill Hill, London NW7 IAA, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/153\/3\/729\/566615\/bj1530729.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/153\/3\/729\/566615\/bj1530729.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T16:53:08Z","timestamp":1637945588000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/153\/3\/729\/9969\/The-prediction-of-the-conformation-of-membrane"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1976,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1530729","relation":{},"ISSN":["0264-6021"],"issn-type":[{"value":"0264-6021","type":"print"}],"subject":[],"published":{"date-parts":[[1976,3,1]]}}}