{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T01:47:13Z","timestamp":1649036833785},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,6,15]]},"abstract":"<jats:p>Ability of the beta-subunit of human chorionic gonadotropin to inhibit the response to lutropin (luteinizing hormone, LH) was tested in the immature rat ovarian system and pregnant-mare-serum-gonadotropin-primed rat ovarian system with progesterone production being used as the response. Human chorionic gonadotropin beta-subunit was found to inhibit human and ovine lutropin-stimulated progesterone production. At a constant dose of lutropin, inhibition was dependent on the concentration of beta-subunit. When concentration of the beta-subunit was kept constant at 5.0 microgram\/ml and the concentration of lutropin was varied, the inhibition was maximum at the saturating concentration of the native hormone. The alpha-subunit of the human chorionic gonadotropin did not inhibit the response to lutropin. The lutropin\/beta-subunit ratio required to produce an inhibition of response was much lower than that required to bring about an observable inhibition of binding.<\/jats:p>","DOI":"10.1042\/bj1800573","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T20:16:46Z","timestamp":1439237806000},"page":"573-578","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ability of human chorionic gonadotropin \u03b2-subunit to inhibit the steroidogenic response to lutropin"],"prefix":"10.1042","volume":"180","author":[{"given":"R R","family":"Dighe","sequence":"first","affiliation":[]},{"given":"K","family":"Muralidhar","sequence":"additional","affiliation":[]},{"given":"N R","family":"Moudgal","sequence":"additional","affiliation":[]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/180\/3\/573\/572752\/bj1800573.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/180\/3\/573\/572752\/bj1800573.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T13:03:17Z","timestamp":1637931797000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/180\/3\/573\/4181\/Ability-of-human-chorionic-gonadotropin-subunit-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,6,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,6,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1800573","relation":{},"ISSN":["0264-6021"],"issn-type":[{"value":"0264-6021","type":"print"}],"subject":[],"published":{"date-parts":[[1979,6,15]]}}}