{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:02:46Z","timestamp":1772895766918,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,6,15]]},"abstract":"<jats:p>The human mucin gene MUC5AC is mapped clustered with MUC2, MUC5B and MUC6 on chromosome 11p15.5. We report here the isolation and characterization of a genomic cosmid clone, designated ELO9, spanning the 3\u00b4-region of MUC5AC and the 5\u00b4-region of MUC5B, allowing us to conclude that MUC5AC and MUC5B have the same transcriptional orientation. We determined the genomic organization and the entire sequence of the 3\u00b4-region of MUC5AC. The comparative molecular analysis of MUC5AC and MUC5B points to a remarkable similarity in the size and the distribution of exons, and in the type of splice sites, supporting the notion that MUC5AC and MUC5B have evolved from a single common ancestral gene. The derivation of the four genes of the 11p15.5 mucin gene family from a single ancestral gene is discussed.<\/jats:p>","DOI":"10.1042\/bj3320729","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T22:02:02Z","timestamp":1439244122000},"page":"729-738","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Genomic organization of the 3\u2032-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family"],"prefix":"10.1042","volume":"332","author":[{"given":"Marie-Pierre","family":"BUISINE","sequence":"first","affiliation":[{"name":"INSERM Unit\u00e9 377, Place de Verdun, 59045 Lille Cedex, France"},{"name":"Laboratoire de Biochimie et Biologie Mol\u00e9culaire, H\u00f4pital C. Huriez, Centre Hospitalier R\u00e9gional et Universitaire, 59037 Lille Cedex, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Lille II, 59045 Lille Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"DESSEYN","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 377, Place de Verdun, 59045 Lille Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"PORCHET","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 377, Place de Verdun, 59045 Lille Cedex, France"},{"name":"Laboratoire de Biochimie et Biologie Mol\u00e9culaire, H\u00f4pital C. Huriez, Centre Hospitalier R\u00e9gional et Universitaire, 59037 Lille Cedex, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Lille II, 59045 Lille Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"DEGAND","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 377, Place de Verdun, 59045 Lille Cedex, France"},{"name":"Laboratoire de Biochimie et Biologie Mol\u00e9culaire, H\u00f4pital C. Huriez, Centre Hospitalier R\u00e9gional et Universitaire, 59037 Lille Cedex, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Lille II, 59045 Lille Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"LAINE","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 377, Place de Verdun, 59045 Lille Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"AUBERT","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 377, Place de Verdun, 59045 Lille Cedex, France"},{"name":"Laboratoire de Biochimie et Biologie Mol\u00e9culaire, H\u00f4pital C. Huriez, Centre Hospitalier R\u00e9gional et Universitaire, 59037 Lille Cedex, France"},{"name":"INSERM Unit\u00e9 377, Place de Verdun, 59045 Lille Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/332\/3\/729\/630725\/bj3320729.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/332\/3\/729\/630725\/bj3320729.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:28:01Z","timestamp":1637713681000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/332\/3\/729\/33643\/Genomic-organization-of-the-3-region-of-the-human"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,6,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj3320729","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,6,15]]}}}