{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T09:53:24Z","timestamp":1700819604233},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1970,9,1]]},"abstract":"<jats:p>1. Circulating kinins were detected and continuously assayed during hypotension due to haemorrhage in dogs, using the blood-bathed organ technique and isolated strips of cat jejunum as the assay tissue.<\/jats:p>\n               <jats:p>2. In arterial blood kinin concentrations of 1\u20135 ng\/ml were attained after a hypotension of 35\u201365 mmHg had been maintained for 10\u2013190 min. When portal venous blood was simultaneously assayed kinins appeared earlier and in concentrations 1\u20132 ng\/ml higher than in arterial blood. No differences in time course of kinin generation or in concentration were found when mixed venous blood and arterial blood were compared. In those instances in which the blood pressure was restored to normal by returning the shed blood, kinin formation stopped.<\/jats:p>\n               <jats:p>3. Kinin generation was due to the presence in the circulation of a kinin-forming enzyme, such as kallikrein. When kallikrein was infused into the portal vein, it was partially inactivated by the liver.<\/jats:p>\n               <jats:p>4. Prolonged intravenous infusions of kallikrein (20\u201360 mu kg\u22121 min\u22121) generated kinins in the circulation in concentrations (1\u20135 ng\/ml) which were well maintained throughout the infusion, demonstrating that kinin generation is not limited by depletion of the precursor kininogen; nevertheless, the effects of kallikrein infusions on the blood pressure and central venous pressure waned.<\/jats:p>\n               <jats:p>5. It is concluded that in hypotension due to haemorrhage, an active kallikrein appears in the portal circulation. Delay in the appearance of kallikrein in the systemic circulation may be due to the kallikrein inactivating mechanism of the liver. This inactivating mechanism may fail during shock. Kinins are generated in amounts sufficient to have a substantial effect on the circulation and an influence on the course of events in shock.<\/jats:p>","DOI":"10.1042\/cs0390349","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:23:04Z","timestamp":1438942984000},"page":"349-365","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Generation of Kinins in the Blood of Dogs during Hypotension Due to Haemorrhage"],"prefix":"10.1042","volume":"39","author":[{"given":"H. E.","family":"Berry","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, London"}]},{"given":"J. G.","family":"Collier","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, London"}]},{"given":"J. R.","family":"Vane","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, London"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/39\/3\/349\/813806\/cs0390349.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/39\/3\/349\/813806\/cs0390349.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T15:03:41Z","timestamp":1638457421000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/39\/3\/349\/70098\/The-Generation-of-Kinins-in-the-Blood-of-Dogs"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0390349","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1970,9,1]]}}}