{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T03:02:38Z","timestamp":1648609358457},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1975,11,1]]},"abstract":"<jats:p>1. The passage of radioactive apolipoproteins into lymph draining the foot was investigated in two men, each given a single intravenous injection of low-density lipoprotein containing 131I-labelled apoprotein B and of very-low-density lipoprotein containing 125I-labelled apoprotein A and apoprotein C.<\/jats:p>\n               <jats:p>2. Protein-bound 125I and 131I appeared in the lymph of both subjects. Immunoelectrophoresis of lymph lipoproteins against anti-(high-density lipoprotein) and anti-(low-density lipoprotein) showed the presence of apo-high-density lipoprotein and apo-low-density lipoprotein with faster mobilities than plasma high-density and low-density lipoprotein respectively. Most of the protein-bound 131I in lymph was recovered in the precipitin line formed by the apoprotein B-containing lipoprotein after immunoelectrophoresis. Polyacrylamide gel electrophoresis of the lymph lipoprotein fraction showed the presence of 125I-containing bands with mobilities similar to those of the apoprotein A of high-density lipoprotein and of three of the fast-moving C apoproteins.<\/jats:p>\n               <jats:p>3. These results suggest that most, if not all, of the apoproteins of plasma lipoproteins reach the interstitial fluids and that some lipoproteins undergo modification during their passage into peripheral lymph.<\/jats:p>","DOI":"10.1042\/cs0490419","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:29:47Z","timestamp":1438928987000},"page":"419-426","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Observations on the Passage of Apoproteins from Plasma Lipoproteins into Peripheral Lymph in Two Men"],"prefix":"10.1042","volume":"49","author":[{"given":"D.","family":"Reichl","sequence":"first","affiliation":[{"name":"Medical Research Council Lipid Metabolism Unit, Hammersmith Hospital, London"},{"name":"Department of Experimental and Reconstructive Surgery, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Postiglione","sequence":"additional","affiliation":[{"name":"Medical Research Council Lipid Metabolism Unit, Hammersmith Hospital, London"},{"name":"Department of Experimental and Reconstructive Surgery, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. B.","family":"Myant","sequence":"additional","affiliation":[{"name":"Medical Research Council Lipid Metabolism Unit, Hammersmith Hospital, London"},{"name":"Department of Experimental and Reconstructive Surgery, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Pflug","sequence":"additional","affiliation":[{"name":"Medical Research Council Lipid Metabolism Unit, Hammersmith Hospital, London"},{"name":"Department of Experimental and Reconstructive Surgery, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Press","sequence":"additional","affiliation":[{"name":"Medical Research Council Lipid Metabolism Unit, Hammersmith Hospital, London"},{"name":"Department of Experimental and Reconstructive Surgery, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/49\/5\/419\/815936\/cs0490419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/49\/5\/419\/815936\/cs0490419.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T23:59:54Z","timestamp":1572047994000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/49\/5\/419\/70766\/Observations-on-the-Passage-of-Apoproteins-from"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1975,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0490419","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1975,11,1]]}}}