{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T19:30:28Z","timestamp":1715542228039},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. Two presynaptic mechanisms appear to be involved in the regulation of noradrenaline release during nerve stimulation. The first one, mediated by \u03b2-adrenoceptors, operates at low frequencies of nerve stimulation, leading to an increase in transmitter release. The second one, mediated through \u03b1-adrenoceptors, is triggered when higher concentrations of the transmitter are reached in the synaptic cleft, leading to inhibition of transmitter release, probably through a restriction in the availability of calcium for the secretory process.<\/jats:p>\n               <jats:p>2. It is postulated that part of the anti-hypertensive effects of drugs like clonidine, \u03b1-methyldopa and \u03b2-receptor-blocking agents may be related to their long-term effects on presynaptic adrenoceptors.<\/jats:p>","DOI":"10.1042\/cs051423s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:31:32Z","timestamp":1438943492000},"page":"423s-426s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of \u03b1- and \u03b2-Presynaptic Receptors in the Regulation of Noradrenaline Release Elicited by Nerve Stimulation"],"prefix":"10.1042","volume":"51","author":[{"given":"S. Z.","family":"Langer","sequence":"first","affiliation":[{"name":"Institute de Investigaciones Farmacologicas, Conicet, Buenos Aires, Argentina"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/423s\/817510\/cs051423s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/423s\/817510\/cs051423s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T11:29:32Z","timestamp":1572002972000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/423s\/101676\/The-Role-of-%CE%B1-and-%CE%B2Presynaptic-Receptors-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051423s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}