{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:50:42Z","timestamp":1760889042179},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,3,1]]},"abstract":"<jats:p>1. Rats were subjected to resection of either the distal 50 cm of small bowel, the caecum or a combined ileocaecal operation. The effects on stool production and growth were observed over the following 8 weeks. Subsequently measurements were made at various levels in the remaining gut of intestinal weight, mucosal thickness, mucosal adenosine 3\u2032:5\u2032-phosphate (cyclic AMP) concentration and the water and bile acid content of luminal material.<\/jats:p>\n               <jats:p>2. Rapid adaptation, in terms of growth and the production of formed stools, was seen after ile-ectomy or caecectomy. This was slower and less complete after ileocaecectomy. Changes in water content indicated that colonic absorption of water was normal after ile-ectomy but impaired after ileocaecectomy.<\/jats:p>\n               <jats:p>3. After ile-ectomy there was growth of the caecum but not colon, whereas after ileocaecectomy there was growth of the remaining colon.<\/jats:p>\n               <jats:p>4. The intraluminal bile acid concentration in the small-gut remnant was markedly decreased at 2 weeks with little further change at 8 weeks after ileal resection. The colonic intraluminal bile acid concentration was only modestly increased after ile-ectomy or ileocaecectomy.<\/jats:p>\n               <jats:p>5. When studied by a perfusion technique in vivo, deoxycholate (2\u00b75 mmol\/l) in intact rats induced a net secretion of water into the colon; by contrast the colon of 8 week ile-ectomized rats absorbed water, although this was at a reduced rate compared with control rats. Deoxycholate increased mucosal cyclic AMP concentrations in the intact rats but not in the ile-ectomized rats.<\/jats:p>\n               <jats:p>6. Sodium ricinoleate (5\u00b70 mmol\/l) inhibited colonic water absorption and when mixed with deoxycholate (2\u00b75 mmol\/l) the effect on water transport was summatory. However, ricinoleate either alone or with deoxycholate did not alter mucosal cyclic AMP concentrations.<\/jats:p>\n               <jats:p>7. These results demonstrate that the colon can absorb water effectively after ile-ectomy in spite of being exposed to increased concentrations of luminal bile acids. This may result in part from an altered mucosal response to secretagogues. If so this represents a form of functional adaptation by the colon to ileal resection.<\/jats:p>","DOI":"10.1042\/cs0540241","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:34:03Z","timestamp":1438943643000},"page":"241-249","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Ileal and Caecal Resection on the Colon of the Rat"],"prefix":"10.1042","volume":"54","author":[{"given":"J. H. B.","family":"Scarpello","sequence":"first","affiliation":[]},{"given":"B. A.","family":"Cary","sequence":"additional","affiliation":[{"name":"Academic Division of Medicine, Royal Hospital, Sheffield, U.K."}]},{"given":"G. E.","family":"Sladen","sequence":"additional","affiliation":[{"name":"Academic Division of Medicine, Royal Hospital, Sheffield, U.K."}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/3\/241\/754059\/cs0540241.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/54\/3\/241\/754059\/cs0540241.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T02:51:26Z","timestamp":1572058286000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/54\/3\/241\/71177\/Effects-of-Ileal-and-Caecal-Resection-on-the-Colon"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0540241","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1978,3,1]]}}}