{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:55:10Z","timestamp":1759341310688},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,12,1]]},"abstract":"<jats:p>1. Captopril (25 mg) reduced plasma angiotensin II (ANG II) by 53% (P &amp;lt; 0\u00b7001) and mean brachial artery pressure (MBAP) by 18\u00b77 mmHg (P &amp;lt; 0\u00b7001) within 75 min in 26 hypertensive patients. After 2 months (on 150\u2013600 mg\/day) MBAP had decreased by 27\u00b71 mmHg (n = 18) with no further change of plasma ANG II. \u03b4MBAP was significantly related to control log plasma renin (PRA) and log ANG II in both conditions.<\/jats:p>\n               <jats:p>2. The acute depressor response to captopril was 11\u00b72 mmHg greater (P &amp;lt; 0\u00b7001) than \u03b4MBAP during saralasin infusion (n = 12).<\/jats:p>\n               <jats:p>3. Heart rate slightly increased after acute administration of captopril (+ 3\u00b73 beats\/min; P &amp;lt; 0\u00b7005), but cardiac output was not significantly affected; systemic vascular resistance decreased by 10% (P &amp;lt; 0\u00b701) with unchanged pulmonary vascular resistance.<\/jats:p>\n               <jats:p>4. During chronic administration, oxygen consumption, cardiac output and stroke volume increased by 15% (P &amp;lt; 0\u00b701), with unchanged heart rate; systemic vascular resistance had dropped by 30% (P &amp;lt; 0\u00b7001).<\/jats:p>\n               <jats:p>5. Plasma ANG II and plasma aldosterone decreased, and PRA and ANG I increased acutely, with no further changes during chronic treatment.<\/jats:p>","DOI":"10.1042\/cs057131s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:36:07Z","timestamp":1438943767000},"page":"131s-134s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Haemodynamic Effects of Captopril in Hypertensive Patients: Comparison with Saralasin"],"prefix":"10.1042","volume":"57","author":[{"given":"R.","family":"Fagard","sequence":"first","affiliation":[{"name":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Pathophysiology, University of Leuven (K. U. Leuven), Leuven, Belgium"}]},{"given":"A.","family":"Amery","sequence":"additional","affiliation":[{"name":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Pathophysiology, University of Leuven (K. U. Leuven), Leuven, Belgium"}]},{"given":"P.","family":"Lijnen","sequence":"additional","affiliation":[{"name":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Pathophysiology, University of Leuven (K. U. Leuven), Leuven, Belgium"}]},{"given":"T.","family":"Reybrouck","sequence":"additional","affiliation":[{"name":"Hypertension and Cardiovascular Rehabilitation Unit, Department of Pathophysiology, University of Leuven (K. U. Leuven), Leuven, Belgium"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/131s\/876066\/cs057131s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/57\/s5\/131s\/876066\/cs057131s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:23:02Z","timestamp":1638480182000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/57\/s5\/131s\/102465\/Haemodynamic-Effects-of-Captopril-in-Hypertensive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12,1]]},"references-count":0,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[1979,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs057131s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1979,12,1]]}}}