{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:30:53Z","timestamp":1781119853964,"version":"3.54.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,8,1]]},"abstract":"<jats:p>1. Calcium metabolism has been investigated in patients with essential hypertension and normal renal function to evaluate the renal calcium handling and the reported increase in renal calcium loss.<\/jats:p>\n               <jats:p>2. In 55 hypertensive and 55 sex- and age-matched healthy normotensive subjects creatinine clearance, serum total and ionized calcium, plasma parathyroid hormone and 24 h urinary excretion of calcium, sodium and cAMP were measured. In a subgroup of 20 hypertensive patients and 20 controls the fasting calcium excretion rate was also measured.<\/jats:p>\n               <jats:p>3. Both 24 h and fasting calcium excretion rates were higher in the hypertensive group; so also were plasma parathyroid hormone and urinary cAMP. Serum total and ionized calcium levels were not different in the two groups.<\/jats:p>\n               <jats:p>4. After intravenous calcium infusion (15 mg 3 h\u22121 kg\u22121) in seven hypertensive patients and controls, the hypertensive patients excreted more calcium at all serum calcium concentrations.<\/jats:p>\n               <jats:p>5. These results support the hypothesis of primary renal calcium leak in essential hypertension. Enhanced urinary calcium excretion rate may cause compensatory parathyroid overactivity.<\/jats:p>","DOI":"10.1042\/cs0650137","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:46:18Z","timestamp":1438944378000},"page":"137-141","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Abnormalities of Calcium Metabolism in Essential Hypertension"],"prefix":"10.1042","volume":"65","author":[{"given":"P.","family":"Strazzullo","sequence":"first","affiliation":[{"name":"Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Nunziata","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Giannattasio","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/2\/137\/454219\/cs0650137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/2\/137\/454219\/cs0650137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:25:55Z","timestamp":1638476755000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/65\/2\/137\/73186\/Abnormalities-of-Calcium-Metabolism-in-Essential"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0650137","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,8,1]]}}}