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Thus, elucidation of matrix components, their function and modulation by the host environment is crucial to disclose their role in C. glabrata pathogenesis. As a major step toward this end, this study aimed to reveal, for the first time, the matrix proteome of C. glabrata biofilms, to characterize it with bioinformatic tools and to study its modulation by the environmental pH (acidic and neutral). The results showed the presence of several pH-specific matrix proteins (51 acidic- and 206 neutral-specific) and also proteins commonly found at both pH conditions (236). Of note, several proteins related to mannan and \u03b2-glucan metabolism, which have a potential role in the delivery\/organization of carbohydrates in the matrix, were found in both pH conditions but in much higher quantity under the neutral environment. Additionally, several virulence-related proteins, including epithelial adhesins, yapsins and moonlighting enzymes, were found among matrix proteins. Importantly, several proteins seem to have a non-canonical secretion pathway and Pdr1 was found to be a potential regulator of matrix proteome. Overall, this study indicates a relevant impact of environmental cues in the matrix proteome and provides a unique resource for further functional investigation of matrix proteins, contributing to the identification of potential targets for the development of new therapies against C. glabrata biofilms.<\/jats:p>","DOI":"10.1042\/bcj20200844","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T14:49:48Z","timestamp":1612795788000},"page":"961-974","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Revealing <i>Candida glabrata<\/i> biofilm matrix proteome: global characterization and pH response"],"prefix":"10.1042","volume":"478","author":[{"given":"Bruna","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"LIBRO \u2014 Biofilm Research Laboratory Ros\u00e1rio Oliveira, CEB \u2014 Center of Biological Engineering, University of Minho, Gualtar Campus, 4715-057 Braga, Portugal"}]},{"given":"Nuno","family":"Azevedo","sequence":"additional","affiliation":[{"name":"LIBRO \u2014 Biofilm Research Laboratory Ros\u00e1rio Oliveira, CEB \u2014 Center of Biological Engineering, University of Minho, Gualtar Campus, 4715-057 Braga, Portugal"}]},{"given":"Hugo","family":"Os\u00f3rio","sequence":"additional","affiliation":[{"name":"i3S \u2014 Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal"},{"name":"Ipatimup \u2014 Institute of Molecular Pathology and Immunology of the University of Porto, University of Porto, 4200-135 Porto, Portugal"},{"name":"Department of Pathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Mariana","family":"Henriques","sequence":"additional","affiliation":[{"name":"LIBRO \u2014 Biofilm Research Laboratory Ros\u00e1rio Oliveira, CEB \u2014 Center of Biological Engineering, University of Minho, Gualtar Campus, 4715-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-7387","authenticated-orcid":false,"given":"S\u00f3nia","family":"Silva","sequence":"additional","affiliation":[{"name":"LIBRO \u2014 Biofilm Research Laboratory Ros\u00e1rio Oliveira, CEB \u2014 Center of Biological Engineering, University of Minho, Gualtar Campus, 4715-057 Braga, Portugal"}]}],"member":"288","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"2021112218183850300_BCJ-2020-0844C1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3109\/1040841X.2015.1091805","article-title":"Vulvovaginal candidiasis: epidemiology, microbiology and risk factors","volume":"42","year":"2016","journal-title":"Crit. 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