{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T09:13:21Z","timestamp":1775985201946,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,1,1]]},"abstract":"<jats:p>Partition of the intrinsically fluorescent HIV fusion inhibitor enfuvirtide into lipidic membranes is relatively high (\u0394G=6.6 kcal\u00b7mol\u22121) and modulated by cholesterol. A shallow position in the lipidic matrix makes it readily available for interaction with gp41. No conformational energetic barrier prevents enfuvirtide from being active in both aqueous solution and lipidic membranes. Lipidic membranes may play a key role in the enfuvirtide biochemical mode of action.<\/jats:p>","DOI":"10.1042\/bj20031350","type":"journal-article","created":{"date-parts":[[2004,1,13]],"date-time":"2004-01-13T09:02:27Z","timestamp":1073984547000},"page":"107-110","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level"],"prefix":"10.1042","volume":"377","author":[{"given":"Salom\u00e9","family":"VEIGA","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande C8, 1749-016 Lisboa, Portugal"}]},{"given":"S\u00f3nia","family":"HENRIQUES","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande C8, 1749-016 Lisboa, Portugal"}]},{"given":"Nuno C.","family":"SANTOS","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica\/Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"given":"Miguel","family":"CASTANHO","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande C8, 1749-016 Lisboa, Portugal"},{"name":"Centro de Qu\u00edmica F\u00edsica Molecular, Instituto Superior T\u00e9cnico, Complexo I, 1049-001 Lisboa, Portugal"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/377\/1\/107\/712486\/bj3770107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/377\/1\/107\/712486\/bj3770107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T13:46:03Z","timestamp":1637588763000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/377\/1\/107\/43130\/Putative-role-of-membranes-in-the-HIV-fusion"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj20031350","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,1]]}}}