{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:45:55Z","timestamp":1773675955118,"version":"3.50.1"},"reference-count":28,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,11,1]]},"abstract":"<jats:p>Secretor status is defined by the expression of H type 1 antigen on gastric surface epithelium and external secretions. The H type 1 structure, and other fucosylated carbohydrates (Lea, sialyl-Lea, Leb, Lex, sialyl-Lex and Ley), can serve as ligands for several pathogens, including Helicobacter pylori, and are cancer-associated antigens. Secretor individuals are more susceptible to some bacterial and viral infections of the genito-urinary and digestive tracts. The aim of the present study was to examine FUT2 (fucosyltransferase 2 gene) polymorphisms in a Caucasian population of non-secretor individuals (n=36) from northern Portugal and to evaluate the activity of the mutant FUT2 enzymes. The secretor status was determined by UEAI [Ulex europaeus (gorse) lectin] histochemistry in gastric mucosa, and FUT2 polymorphisms were studied by restriction-fragment-length polymorphism and direct sequencing. The majority of non-secretors (88.9%) were homozygous for 428G\u2192A polymorphism; 5.6% were homozygous for 571C\u2192T and 5.6% were homozygous for two new missense polymorphisms, 739G\u2192A (2.8%) and 839T\u2192C (2.8%). By kinetic studies it was demonstrated that the two new FUT2 mutants (739G\u2192A and 839T\u2192C) are almost inactive and are responsible for some non-secretor cases.<\/jats:p>","DOI":"10.1042\/bj20040803","type":"journal-article","created":{"date-parts":[[2004,10,26]],"date-time":"2004-10-26T10:23:11Z","timestamp":1098786191000},"page":"469-474","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Two new <i>FUT2<\/i> (fucosyltransferase 2 gene) missense polymorphisms, 739G\u2192A and 839T\u2192C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal"],"prefix":"10.1042","volume":"383","author":[{"given":"Jacinta","family":"SERPA","sequence":"first","affiliation":[{"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Rua Dr Roberto Frias s\/n, 4200-465 Porto, Portugal"}]},{"given":"Nuno","family":"MENDES","sequence":"additional","affiliation":[{"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Rua Dr Roberto Frias s\/n, 4200-465 Porto, Portugal"}]},{"given":"Celso\u00a0A.","family":"REIS","sequence":"additional","affiliation":[{"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Rua Dr Roberto Frias s\/n, 4200-465 Porto, Portugal"}]},{"given":"Luis\u00a0F.","family":"SANTOS\u00a0SILVA","sequence":"additional","affiliation":[{"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Rua Dr Roberto Frias s\/n, 4200-465 Porto, Portugal"}]},{"given":"Raquel","family":"ALMEIDA","sequence":"additional","affiliation":[{"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Rua Dr Roberto Frias s\/n, 4200-465 Porto, Portugal"}]},{"given":"Jacques","family":"LE\u00a0PENDU","sequence":"additional","affiliation":[{"name":"INSERM U601, Institute of Biology, 9 Quai Moncousu, 44093 Nantes, France"}]},{"given":"Leonor","family":"DAVID","sequence":"additional","affiliation":[{"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Rua Dr Roberto Frias s\/n, 4200-465 Porto, Portugal"},{"name":"Faculdade M\u00e9dica da Universidade do Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]}],"member":"288","published-online":{"date-parts":[[2004,10,26]]},"reference":[{"key":"2021112217421308800_B1","first-page":"671","article-title":"Lewis antigen alterations in a population at high risk of stomach cancer","volume":"9","author":"Torrado","year":"2000","journal-title":"Cancer Epidemiol. 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