{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:29:30Z","timestamp":1770499770984,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:p>14-3-3 proteins are involved in signalling processes in neuronal cells. Using isoform-specific antibodies we have examined the variation in 14-3-3 isoform neurolocation in normal and scrapie-infected murine brain and show that in defined areas of the brain there are significant changes associated with the pathology of the disease process. The appearance of 14-3-3 proteins in the cerebrospinal fluid (CSF) is a consequence of neuronal disease and the detection of specific isoforms of the 14-3-3 proteins in the CSF is characteristic of some neurodegenerative diseases. In this study, monitoring specifically for the\u03b3 14-3-3 isoform in the CSF by both Western-blot analysis and ELISA we can show a level of correlation between the assays.<\/jats:p>","DOI":"10.1042\/bst0300387","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T09:39:54Z","timestamp":1088069994000},"page":"387-391","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Specific 14-3-3 isoform detection and immunolocalization in prion diseases"],"prefix":"10.1042","volume":"30","author":[{"given":"H. C.","family":"Baxter","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, U.K."}]},{"given":"J. R.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Institute for Animal Health, Neuropathogenesis Unit, Edinburgh EH9 3JF, U.K."}]},{"given":"W.-G.","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute for Animal Health, Neuropathogenesis Unit, Edinburgh EH9 3JF, U.K."}]},{"given":"J. L.","family":"Forster","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, U.K."}]},{"given":"S.","family":"Clokie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, U.K."}]},{"given":"P.","family":"Steinacker","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuropathology and Psychiatry, University of Gottingen, D-37075, Gottingen, Germany"}]},{"given":"M.","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuropathology and Psychiatry, University of Gottingen, D-37075, Gottingen, Germany"}]},{"given":"E.","family":"Bahn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuropathology and Psychiatry, University of Gottingen, D-37075, Gottingen, Germany"}]},{"given":"J.","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuropathology and Psychiatry, University of Gottingen, D-37075, Gottingen, Germany"}]},{"given":"A.","family":"Aitken","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, U.K."}]}],"member":"288","container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/30\/4\/387\/535875\/bst0300387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/30\/4\/387\/535875\/bst0300387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T21:33:58Z","timestamp":1637184838000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/30\/4\/387\/64798\/Specific-14-3-3-isoform-detection-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bst0300387","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,1]]}}}