{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:42:18Z","timestamp":1767840138259,"version":"3.49.0"},"reference-count":67,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,2,1]]},"abstract":"<jats:p>ESCRT-III (endosomal sorting complex required for transport III) is required for the formation and abscission of intraluminal endosomal vesicles, which gives rise to multivesicular bodies, budding of some enveloped viruses and cytokinesis. ESCRT-III is composed of 11 members in humans, which, except for one, correspond to the six ESCRT-III-like proteins in yeast. At least CHMP (charged multivesicular body protein) 2A and CHMP3 assemble into helical tubular structures that provide a platform for membrane interaction and VPS (vacuolar protein sorting) 4-catalysed effects leading to disassembly of ESCRT-III CHMP2A\u2013CHMP3 polymers in vitro. Progress towards the understanding of the structures and function of ESCRT-III, its activation, its regulation by accessory factors and its role in abscission of membrane enveloped structures in concert with VPS4 are discussed.<\/jats:p>","DOI":"10.1042\/bst0370156","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T10:03:13Z","timestamp":1232618593000},"page":"156-160","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Structure and function of ESCRT-III"],"prefix":"10.1042","volume":"37","author":[{"given":"Suman","family":"Lata","sequence":"first","affiliation":[{"name":"Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France"}]},{"given":"Guy","family":"Schoehn","sequence":"additional","affiliation":[{"name":"Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France"},{"name":"Institut de Biologie Structurale Jean-Pierre UMR 5075 CEA-CNRS-UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France"}]},{"given":"Julianna","family":"Solomons","sequence":"additional","affiliation":[{"name":"Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France"}]},{"given":"Ricardo","family":"Pires","sequence":"additional","affiliation":[{"name":"Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France"}]},{"given":"Heinrich\u00a0G.","family":"G\u00f6ttlinger","sequence":"additional","affiliation":[{"name":"Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A."}]},{"given":"Winfried","family":"Weissenhorn","sequence":"additional","affiliation":[{"name":"Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France"}]}],"member":"288","published-online":{"date-parts":[[2009,1,20]]},"reference":[{"key":"2021111719592368300_B1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tibs.2007.09.010","article-title":"ESCRTing proteins in the endocytic pathway","volume":"32","author":"Saksena","year":"2007","journal-title":"Trends Biochem. 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