{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T16:12:48Z","timestamp":1773591168774,"version":"3.50.1"},"reference-count":81,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:p>IM (intestinal metaplasia) of the stomach is a pre-neoplastic lesion that usually follows Helicobacter pylori infection and that confers increased risk for gastric cancer development. After setting the role played by CDX2 (Caudal-type homeobox 2) in the establishment of gastric IM, it became of foremost importance to unravel the regulatory mechanisms behind its de novo expression in the stomach. In the present paper, we review the basic pathology of gastric IM as well as the current knowledge on molecular pathways involved in CDX2 regulation in the gastric context.<\/jats:p>","DOI":"10.1042\/bst0380358","type":"journal-article","created":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T14:16:27Z","timestamp":1269440187000},"page":"358-363","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Pathophysiology of intestinal metaplasia of the stomach: emphasis on <i>CDX2<\/i> regulation"],"prefix":"10.1042","volume":"38","author":[{"given":"Rita","family":"Barros","sequence":"first","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr. Roberto Frias s\/n, 4200-465 Porto, Portugal"},{"name":"Medical Faculty, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, 4200-319, Porto, Portugal"}]},{"given":"V\u00e2nia","family":"Camilo","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr. Roberto Frias s\/n, 4200-465 Porto, Portugal"},{"name":"Medical Faculty, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, 4200-319, Porto, Portugal"}]},{"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr. Roberto Frias s\/n, 4200-465 Porto, Portugal"},{"name":"Medical Faculty, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, 4200-319, Porto, Portugal"}]},{"given":"Jean-Noel","family":"Freund","sequence":"additional","affiliation":[{"name":"INSERM U682, 3, Av. 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