{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:51:42Z","timestamp":1760385102687},"reference-count":30,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:p>Sperm chemotaxis is a long-term puzzle and most of our knowledge comes from studying marine animals that are external fertilizers. Sperm are attracted by diffusible chemical factors (chemoattractants) released from the egg which redirect their swimming paths towards their source. This redirection is driven by increases in flagellar curvature that correlate with transient flagellar Ca2+ increases. Recent experimental and modelling results provide insights into the signal flow underlying the translation of an external chemical gradient into an intracellular molecular and motor response. A fundamental element of sea-urchin sperm chemotaxis lies in the ability of these cells to suppress Ca2+-mediated increases in flagellar curvature while experiencing an increasing chemoattractant gradient. The article considers this new evidence and summarizes the known underlying cellular mechanisms and behavioural strategies that sperm use to locate and fertilize the oocyte.<\/jats:p>","DOI":"10.1042\/bst0381270","type":"journal-article","created":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T15:47:17Z","timestamp":1285343237000},"page":"1270-1274","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Tuning sperm chemotaxis"],"prefix":"10.1042","volume":"38","author":[{"given":"Ad\u00e1n","family":"Guerrero","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad, 2001 Col. Chamilpa, Cuernavaca, Morelos, Mexico"}]},{"given":"Christopher\u00a0D.","family":"Wood","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad, 2001 Col. Chamilpa, Cuernavaca, Morelos, Mexico"}]},{"given":"Takuya","family":"Nishigaki","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad, 2001 Col. Chamilpa, Cuernavaca, Morelos, Mexico"}]},{"given":"Jorge","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, P-2780-156 Oeiras, Portugal"}]},{"given":"Alberto","family":"Darszon","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad, 2001 Col. Chamilpa, Cuernavaca, Morelos, Mexico"}]}],"member":"288","published-online":{"date-parts":[[2010,9,24]]},"reference":[{"key":"2021111823045567200_B1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrm1893","article-title":"Sperm guidance in mammals \u2013 an unpaved road to the egg","volume":"7","author":"Eisenbach","year":"2006","journal-title":"Nat Rev Mol. Cell. 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