{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:09:17Z","timestamp":1767625757155},"reference-count":51,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>Sister-chromatid cohesion, thought to be primarily mediated by the cohesin complex, is essential for chromosome segregation. The forces holding the two sisters resist the tendency of microtubules to prematurely pull sister DNAs apart and thereby prevent random segregation of the genome during mitosis, and consequent aneuploidy. By counteracting the spindle pulling forces, cohesion between the two sisters generates the tension necessary to stabilize microtubule\u2013kinetochore attachments. Upon entry into anaphase, however, the linkages that hold the two sister DNAs must be rapidly destroyed to allow physical separation of chromatids. Anaphase cells must therefore possess mechanisms that ensure faithful segregation of single chromatids that are now attached stably to the spindle in a manner no longer dependent on tension. In the present review, we discuss the nature of the cohesive forces that hold sister chromatids together, the mechanisms that trigger their physical separation, and the anaphase-specific changes that ensure proper segregation of single chromatids during the later stages of mitosis.<\/jats:p>","DOI":"10.1042\/bst0381639","type":"journal-article","created":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T15:07:34Z","timestamp":1291216054000},"page":"1639-1644","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Getting through anaphase: splitting the sisters and beyond"],"prefix":"10.1042","volume":"38","author":[{"given":"Raquel\u00a0A.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K."}]},{"given":"Kim","family":"Nasmyth","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K."}]}],"member":"288","published-online":{"date-parts":[[2010,11,24]]},"reference":[{"key":"2021111909373126700_B1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0092-8674(01)80007-6","article-title":"Cohesins: chromosomal proteins that prevent premature separation of sister chromatids","volume":"91","author":"Michaelis","year":"1997","journal-title":"Cell"},{"key":"2021111909373126700_B2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(01)80008-8","article-title":"A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae","volume":"91","author":"Guacci","year":"1997","journal-title":"Cell"},{"key":"2021111909373126700_B3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1146\/annurev-genet-102108-134233","article-title":"Cohesin: its roles and mechanisms","volume":"43","author":"Nasmyth","year":"2009","journal-title":"Annu. 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