{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:55:21Z","timestamp":1679360121673},"reference-count":50,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>The CPC [chromosomal passenger complex; INCENP (inner centromere protein), Aurora B kinase, survivin and borealin] is implicated in many mitotic processes. In the present paper we describe how we generated DT40 conditional-knockout cell lines for incenp1 and survivin1 to better understand the role of these CPC subunits in the control of Aurora B kinase activity. These lines enabled us to reassess current knowledge of survivin function and to show that INCENP acts as a rheostat for Aurora B activity.<\/jats:p>","DOI":"10.1042\/bst0381655","type":"journal-article","created":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T15:07:34Z","timestamp":1291216054000},"page":"1655-1659","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function"],"prefix":"10.1042","volume":"38","author":[{"given":"Xavier","family":"Fant","sequence":"first","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, U.K."}]},{"given":"Kumiko","family":"Samejima","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, U.K."}]},{"given":"Ana","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, U.K."},{"name":"Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653, U.S.A."}]},{"given":"Hiromi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, U.K."}]},{"given":"Zhenjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, U.K."},{"name":"Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305-5345, U.S.A."}]},{"given":"Zuojun","family":"Yue","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, U.K."},{"name":"Cell and Developmental Biology, The University of Dundee, Dundee DD1 5EH, Scotland, U.K."}]},{"given":"William\u00a0C.","family":"Earnshaw","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, U.K."}]},{"given":"Sandrine","family":"Ruchaud","sequence":"additional","affiliation":[{"name":"CNRS USR3151, Station Biologique de Roscoff, place G. 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