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In the present review, we show that Rab GTPases are disregulated in many cancers and have central roles in tumour cell migration, invasion, proliferation, communication with stromal cells and the development of drug resistance. As a consequence, Rab proteins may be novel potential candidates for the development of anticancer drugs and, in this context, the preliminary results obtained with an inhibitor of Rab function are also discussed.<\/jats:p>","DOI":"10.1042\/bst20120199","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T17:09:55Z","timestamp":1353690595000},"page":"1398-1403","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Novel functions for Rab GTPases in multiple aspects of tumour progression"],"prefix":"10.1042","volume":"40","author":[{"given":"Chiara","family":"Recchi","sequence":"first","affiliation":[{"name":"Molecular Medicine Section, National Heart and Lung Institute (NHLI), Imperial College London, London SW7 2AZ, U.K."}]},{"given":"Miguel\u00a0C.","family":"Seabra","sequence":"additional","affiliation":[{"name":"Molecular Medicine Section, National Heart and Lung Institute (NHLI), Imperial College London, London SW7 2AZ, U.K."},{"name":"Centro de Estudos de Doen\u00e7as Cr\u00f3nicas (CEDOC), Faculdade de Ci\u00eancias Medicas, Universidade Nova de Lisboa, Lisbon, Portugal"}]}],"member":"288","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"2021111720485489700_B1","doi-asserted-by":"crossref","first-page":"e1002217","DOI":"10.1371\/journal.pcbi.1002217","article-title":"Thousands of rab GTPases for the cell biologist","volume":"7","author":"Diekmann","year":"2011","journal-title":"PLoS Comput. 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