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The latter sequence differs between subunits and contains most sites for post-translational modifications of the receptors, including phosphorylation, O-GlcNAcylation, ubiquitination, acetylation, palmitoylation and nitrosylation, which affect differentially the various subunits. Considering that each single subunit may undergo modifications in multiple sites, and that AMPA receptors may be formed by the assembly of different subunits, this creates multiple layers of regulation of the receptors with impact in synaptic function and plasticity. This review discusses the diversity of mechanisms involved in the post-translational modification of AMPA receptor subunits, and their impact on the subcellular distribution and synaptic activity of the receptors.<\/jats:p>","DOI":"10.1042\/bst20220827","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T14:39:56Z","timestamp":1673447996000},"page":"315-330","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The role of post-translational modifications in synaptic AMPA receptor activity"],"prefix":"10.1042","volume":"51","author":[{"given":"Elisa","family":"Corti","sequence":"first","affiliation":[{"name":"1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal"},{"name":"2Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-0208","authenticated-orcid":false,"given":"Carlos B.","family":"Duarte","sequence":"additional","affiliation":[{"name":"1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal"},{"name":"3Department of Life Sciences, University of Coimbra, Coimbra, Portugal"}]}],"member":"288","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"2023022712084591100_","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/cne.903180309","article-title":"Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain","volume":"318","year":"1992","journal-title":"J. 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