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This review will discuss these stages of operation, including fluidic handling, which assures that the desired fluid arrives at a specific location at the right time and under the appropriate flow conditions; molecular recognition, which allows the capture of specific analytes at precise locations on the chip; transduction of the molecular recognition event into a measurable signal; sample preparation upstream from analyte capture; and signal amplification procedures to increase sensitivity. Seamless integration of the different stages is required to achieve a point-of-care\/point-of-use lab-on-chip device that allows analyte detection at the relevant sensitivity ranges, with a competitive analysis time and cost.<\/jats:p>","DOI":"10.1042\/ebc20150013","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T10:42:42Z","timestamp":1467283362000},"page":"121-131","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Lab-on-chip systems for integrated bioanalyses"],"prefix":"10.1042","volume":"60","author":[{"given":"Jo\u00e3o\u00a0Pedro","family":"Conde","sequence":"additional","affiliation":[{"name":"Instituto de Engenharia de Sistemas E Computadores\u2013Microsistemas e Nanotecnologias (INESC MN) and IN\u2013Institute of Nanoscience and Nanotechnology, Rua Alves Redol, 9, 1000-029 Lisbon, Portugal"},{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, University of Lisbon, 1049-001, Lisbon, Portugal"}]},{"given":"Narayanan","family":"Madaboosi","sequence":"additional","affiliation":[{"name":"Instituto de Engenharia de Sistemas E Computadores\u2013Microsistemas e Nanotecnologias (INESC MN) and IN\u2013Institute of Nanoscience and Nanotechnology, Rua Alves Redol, 9, 1000-029 Lisbon, Portugal"}]},{"given":"Ruben\u00a0R.G.","family":"Soares","sequence":"additional","affiliation":[{"name":"Instituto de Engenharia de Sistemas E Computadores\u2013Microsistemas e Nanotecnologias (INESC MN) and IN\u2013Institute of Nanoscience and Nanotechnology, Rua Alves Redol, 9, 1000-029 Lisbon, Portugal"}]},{"given":"Jo\u00e3o Tiago S.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Instituto de Engenharia de Sistemas E Computadores\u2013Microsistemas e Nanotecnologias (INESC MN) and IN\u2013Institute of Nanoscience and Nanotechnology, Rua Alves Redol, 9, 1000-029 Lisbon, Portugal"}]},{"given":"Pedro","family":"Novo","sequence":"additional","affiliation":[{"name":"Instituto de Engenharia de Sistemas E Computadores\u2013Microsistemas e Nanotecnologias (INESC MN) and IN\u2013Institute of Nanoscience and Nanotechnology, Rua Alves Redol, 9, 1000-029 Lisbon, Portugal"}]},{"given":"Geraud","family":"Moulas","sequence":"additional","affiliation":[{"name":"Instituto de Engenharia de Sistemas E Computadores\u2013Microsistemas e Nanotecnologias (INESC MN) and IN\u2013Institute of Nanoscience and Nanotechnology, Rua Alves Redol, 9, 1000-029 Lisbon, Portugal"}]},{"given":"Virginia","family":"Chu","sequence":"additional","affiliation":[{"name":"Instituto de Engenharia de Sistemas E Computadores\u2013Microsistemas e Nanotecnologias (INESC MN) and IN\u2013Institute of Nanoscience and Nanotechnology, Rua Alves Redol, 9, 1000-029 Lisbon, Portugal"}]}],"member":"288","published-online":{"date-parts":[[2016,6,30]]},"reference":[{"key":"2021111610135569700_B1","volume-title":"Fundamentals of microfabrication: the science of miniaturization","author":"Madou","year":"2002","edition":"2nd edn"},{"key":"2021111610135569700_B2","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1088\/0964-1726\/10\/6\/301","article-title":"Microelectromechanical systems (MEMS): fabrication, design and applications","volume":"10","author":"Judy","year":"2001","journal-title":"Smart Mater. 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