{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T04:25:30Z","timestamp":1750393530435,"version":"3.37.3"},"reference-count":76,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The importance of Hox genes for the development and evolution of the vertebrate axial skeleton and paired appendages has been recognized for already several decades. The steady growth of genomic sequence data from an increasing number of vertebrate species, together with the improvement of methods to analyze genomic structure and interactions, as well as to control gene activity in various species has refined our understanding of Hox gene activity in development and evolution. Here, I will review recent data addressing the influence of Hox regulatory processes in the evolution of the fins and the emergence of the tetrapod limb. In addition, I will discuss the involvement of posterior Hox genes in the control of vertebrate axial extension, focusing on an apparently divergent activity that Hox13 paralog group genes have on the regulation of tail bud development in mouse and zebrafish embryos.<\/jats:p>","DOI":"10.1042\/ebc20220050","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T07:16:34Z","timestamp":1659597394000},"page":"717-726","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Shaping <i>Hox<\/i> gene activity to generate morphological diversity across vertebrate phylogeny"],"prefix":"10.1042","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9744-0912","authenticated-orcid":false,"given":"Mois\u00e9s","family":"Mallo","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal"}]}],"member":"288","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"2022120816245149900_B1","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/nrg1726","article-title":"Modulating Hox gene functions during animal body patterning","volume":"6","author":"Pearson","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"2022120816245149900_B2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0092-8674(94)90290-9","article-title":"Hox genes in vertebrate development","volume":"78","author":"Krumlauf","year":"1994","journal-title":"Cell"},{"key":"2022120816245149900_B3","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1002\/jez.b.22726","article-title":"Diversification of Hox gene clusters in osteoglossomorph fish in comparison to other teleosts and the spotted gar outgroup","volume":"328","author":"Martin","year":"2017","journal-title":"J. Exp. Zoolog. B Mol. Dev. Evol."},{"key":"2022120816245149900_B4","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1371\/journal.pbio.0050101","article-title":"Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome","volume":"5","author":"Venkatesh","year":"2007","journal-title":"PLoS Biol."},{"key":"2022120816245149900_B5","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nrc2826","article-title":"The Hox genes and their roles in oncogenesis","volume":"10","author":"Shah","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"2022120816245149900_B6","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1007\/s11914-014-0241-0","article-title":"Hox genes and limb musculoskeletal development","volume":"12","author":"Pineault","year":"2014","journal-title":"Curr. Osteoporosis Rep."},{"key":"2022120816245149900_B7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/bs.ctdb.2020.03.001","article-title":"A Hox gene regulatory network for hindbrain segmentation","volume":"139","author":"Marker","year":"2020","journal-title":"Curr. Top. Dev. Biol."},{"key":"2022120816245149900_B8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ydbio.2010.04.024","article-title":"Hox genes and regional patterning of the vertebrate body plan","volume":"344","author":"Mallo","year":"2010","journal-title":"Dev. Biol."},{"key":"2022120816245149900_B9","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1002\/dvdy.21286","article-title":"Hox patterning of the vertebrate axial skeleton","volume":"236","author":"Wellik","year":"2007","journal-title":"Dev. Dyn."},{"key":"2022120816245149900_B10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuron.2013.09.020","article-title":"Hox genes: choreographers in neural development, architects of circuit organization","volume":"80","author":"Philippidou","year":"2013","journal-title":"Neuron"},{"key":"2022120816245149900_B11","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1387\/ijdb.180200mr","article-title":"Role of hox genes in regulating digit patterning","volume":"62","author":"P\u00e9rez-G\u00f3mez","year":"2018","journal-title":"Int. J. Dev. Biol."},{"key":"2022120816245149900_B12","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1242\/dev.068346","article-title":"The regulation of Hox gene expression during animal development","volume":"140","author":"Mallo","year":"2013","journal-title":"Development"},{"key":"2022120816245149900_B13","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1101\/gad.303123.117","article-title":"Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock","volume":"31","author":"Deschamps","year":"2017","journal-title":"Genes & Development"},{"key":"2022120816245149900_B14","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1086\/425183","article-title":"The greatest step in vertebrate history: a paleobiological review of the fish-tetrapod transition","volume":"77","author":"Long","year":"2004","journal-title":"Physiol. Biochem. Zool."},{"key":"2022120816245149900_B15","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1046\/j.1525-142X.2002.02026.x","article-title":"Fins to limbs: what the fossils say","volume":"4","author":"Coates","year":"2002","journal-title":"Evol. Dev."},{"key":"2022120816245149900_B16","doi-asserted-by":"publisher","first-page":"R467","DOI":"10.1016\/j.cub.2021.03.096","article-title":"Evolution: The deep genetic roots of tetrapod-specific traits","volume":"31","author":"Nakamura","year":"2021","journal-title":"Curr. Biol."},{"key":"2022120816245149900_B17","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.devcel.2010.04.002","article-title":"The origin of digits: expression patterns versus regulatory mechanisms","volume":"18","author":"Woltering","year":"2010","journal-title":"Dev. Cell."},{"key":"2022120816245149900_B18","doi-asserted-by":"publisher","first-page":"eabc3510","DOI":"10.1126\/sciadv.abc3510","article-title":"Sarcopterygian fin ontogeny elucidates the origin of hands with digits","volume":"6","author":"Woltering","year":"2020","journal-title":"Sci. Adv."},{"key":"2022120816245149900_B19","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/nature03648","article-title":"Early developmental arrest of mammalian limbs lacking HoxA\/HoxD gene function","volume":"435","author":"Kmita","year":"2005","journal-title":"Nature"},{"key":"2022120816245149900_B20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.devcel.2005.11.014","article-title":"Control of Hoxd genes' collinearity during early limb development","volume":"10","author":"Tarchini","year":"2006","journal-title":"Dev. Cell."},{"key":"2022120816245149900_B21","doi-asserted-by":"publisher","first-page":"1234167","DOI":"10.1126\/science.1234167","article-title":"A switch between topological domains underlies HoxD genes collinearity in mouse limbs","volume":"340","author":"Andrey","year":"2013","journal-title":"Science (1979)"},{"key":"2022120816245149900_B22","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1242\/dev.122.10.2997","article-title":"Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod","volume":"122","author":"Fromental-Ramain","year":"1996","journal-title":"Development"},{"key":"2022120816245149900_B23","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nature05838","article-title":"An autopodial-like pattern of Hox expression in the fins of a basal actinopterygian fish","volume":"447","author":"Davis","year":"2007","journal-title":"Nature"},{"key":"2022120816245149900_B24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.ydbio.2008.06.032","article-title":"Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: Implications for the evolution of vertebrate paired appendages","volume":"322","author":"Ahn","year":"2008","journal-title":"Dev. Biol."},{"key":"2022120816245149900_B25","doi-asserted-by":"publisher","first-page":"e754","DOI":"10.1371\/journal.pone.0000754","article-title":"Biphasic Hoxd gene expression in shark paired fins reveals an ancient origin of the distal limb domain","volume":"2","author":"Freitas","year":"2007","journal-title":"PLoS ONE"},{"key":"2022120816245149900_B26","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nature19322","article-title":"Digits and fin rays share common developmental histories","volume":"537","author":"Nakamura","year":"2016","journal-title":"Nature"},{"key":"2022120816245149900_B27","doi-asserted-by":"publisher","first-page":"e1001773","DOI":"10.1371\/journal.pbio.1001773","article-title":"Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits","volume":"12","author":"Woltering","year":"2014","journal-title":"PLoS Biol."},{"key":"2022120816245149900_B28","first-page":"e1004018","article-title":"Clustering of tissue-specific sub-TADs accompanies the regulation of HoxA genes in developing limbs","volume":"9","author":"Berlivet","year":"2013","journal-title":"PLoS Biol."},{"key":"2022120816245149900_B29","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/ng.3497","article-title":"A single three-dimensional chromatin compartment in amphioxus indicates a stepwise evolution of vertebrate Hox bimodal regulation","volume":"48","author":"Acemel","year":"2016","journal-title":"Nat. Genet."},{"key":"2022120816245149900_B30","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nature11049","article-title":"Spatial partitioning of the regulatory landscape of the X-inactivation centre","volume":"485","author":"Nora","year":"2012","journal-title":"Nature"},{"key":"2022120816245149900_B31","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature11082","article-title":"Topological domains in mammalian genomes identified by analysis of chromatin interactions","volume":"485","author":"Dixon","year":"2012","journal-title":"Nature"},{"key":"2022120816245149900_B32","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.cell.2011.10.023","article-title":"A regulatory archipelago controls hox genes transcription in digits","volume":"147","author":"Montavon","year":"2011","journal-title":"Cell"},{"key":"2022120816245149900_B33","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.ydbio.2007.03.020","article-title":"Transgenic analysis of Hoxd gene regulation during digit development","volume":"306","author":"Gonzalez","year":"2007","journal-title":"Dev. Biol."},{"key":"2022120816245149900_B34","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1073\/pnas.1420208112","article-title":"Deep conservation of wrist and digit enhancers in fish","volume":"112","author":"Gehrke","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022120816245149900_B35","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nature12027","article-title":"The African coelacanth genome provides insights into tetrapod evolution","volume":"496","author":"Amemiya","year":"2013","journal-title":"Nature"},{"key":"2022120816245149900_B36","doi-asserted-by":"publisher","first-page":"12782","DOI":"10.1073\/pnas.1109993108","article-title":"Appendage expression driven by the Hoxd Global Control Region is an ancient gnathostome feature","volume":"108","author":"Schneider","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022120816245149900_B37","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1073\/pnas.1420208112","article-title":"Deep conservation of wrist and digit enhancers in fish","volume":"112","author":"Gehrke","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022120816245149900_B38","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1101\/gad.281055.116","article-title":"A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus","volume":"30","author":"Beccari","year":"2016","journal-title":"Genes Dev."},{"key":"2022120816245149900_B39","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nature19813","article-title":"Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state","volume":"539","author":"Kherdjemil","year":"2016","journal-title":"Nature"},{"key":"2022120816245149900_B40","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1242\/dev.122.5.1449","article-title":"Analysis of Hox gene expression in the chick limb bud","volume":"122","author":"Nelson","year":"1996","journal-title":"Development"},{"key":"2022120816245149900_B41","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/j.1525-142X.2005.05021.x","article-title":"Expression of Hoxa-11 and Hoxa-13 in the pectoral fin of a basal ray-finned fish, Polyodon spathula: implications for the origin of tetrapod limbs","volume":"7","author":"Metscher","year":"2005","journal-title":"Evol. Dev."},{"key":"2022120816245149900_B42","doi-asserted-by":"publisher","first-page":"1362.e18","DOI":"10.1016\/j.cell.2021.01.047","article-title":"African lungfish genome sheds light on the vertebrate water-to-land transition","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"key":"2022120816245149900_B43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/jdb4010010","article-title":"HoxA genes and the fin-to-limb transition in vertebrates","volume":"4","author":"Leite-Castro","year":"2016","journal-title":"J. Dev. Biol."},{"key":"2022120816245149900_B44","doi-asserted-by":"publisher","first-page":"15940","DOI":"10.1073\/pnas.1521818112","article-title":"Molecular mechanisms underlying the exceptional adaptations of batoid fins","volume":"112","author":"Nakamura","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022120816245149900_B45","doi-asserted-by":"publisher","DOI":"10.1101\/2022.03.21.485123","article-title":"The little skate genome and the evolutionary emergence of wing-like fin appendages","author":"Marletaz","year":"2022","journal-title":"bioRxiv."},{"key":"2022120816245149900_B46","doi-asserted-by":"publisher","first-page":"859","DOI":"10.12688\/f1000research.7663.1","article-title":"Hox genes and evolution","volume":"5","author":"Hrycaj","year":"2016","journal-title":"F1000 Res."},{"key":"2022120816245149900_B47","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.tig.2017.11.007","article-title":"Reassessing the role of Hox genes during vertebrate development and evolution","volume":"34","author":"Mallo","year":"2018","journal-title":"Trends Genet."},{"key":"2022120816245149900_B48","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1242\/dev.121.2.333","article-title":"Hox genes and the evolution of vertebrate axial morphology","volume":"121","author":"Burke","year":"1995","journal-title":"Development"},{"key":"2022120816245149900_B49","first-page":"549","article-title":"Conservation in the Hox code during morphological evolution","volume":"38","author":"Gaunt","year":"1994","journal-title":"Int. J. Dev. Biol."},{"key":"2022120816245149900_B50","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ydbio.2009.04.031","article-title":"Axial patterning in snakes and caecilians: evidence for an alternative interpretation of the Hox code","volume":"332","author":"Woltering","year":"2009","journal-title":"Dev. Biol."},{"key":"2022120816245149900_B51","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature08789","article-title":"Changes in Hox genes\u2019 structure and function during the evolution of the squamate body plan","volume":"464","author":"Di-Po\u00ef","year":"2010","journal-title":"Nature"},{"key":"2022120816245149900_B52","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1101\/gad.338705","article-title":"Hox genes specify vertebral types in the presomitic mesoderm","volume":"19","author":"Carapu\u00e7o","year":"2005","journal-title":"Genes Dev."},{"key":"2022120816245149900_B53","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1101\/gad.479408","article-title":"VACTERL\/caudal regression\/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5","volume":"22","author":"Szumska","year":"2008","journal-title":"Genes Dev."},{"key":"2022120816245149900_B54","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/10320","article-title":"Regulation of anterior\/posterior patterning of the axial skeleton by growth\/differentiation factor 11","volume":"22","author":"McPherron","year":"1999","journal-title":"Nat. Genet."},{"key":"2022120816245149900_B55","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.devcel.2013.05.009","article-title":"Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos","volume":"25","author":"Jurberg","year":"2013","journal-title":"Dev. Cell."},{"key":"2022120816245149900_B56","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1126\/science.1085672","article-title":"Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton","volume":"301","author":"Wellik","year":"2003","journal-title":"Science"},{"key":"2022120816245149900_B57","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S0012-1606(02)00137-9","article-title":"Hoxb13 mutations cause overgrowth of caudal spinal cordand tail vertebrae","volume":"256","author":"Economides","year":"2003","journal-title":"Dev. Biol."},{"key":"2022120816245149900_B58","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.devcel.2018.12.004","article-title":"Tail bud progenitor activity relies on a network comprising Gdf11, Lin28, and Hox13 genes","volume":"48","author":"Aires","year":"2019","journal-title":"Dev. Cell."},{"key":"2022120816245149900_B59","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.devcel.2009.08.010","article-title":"Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos","volume":"17","author":"Young","year":"2009","journal-title":"Dev. Cell."},{"key":"2022120816245149900_B60","doi-asserted-by":"publisher","first-page":"e04379","DOI":"10.7554\/eLife.04379","article-title":"Hox genes control vertebrate body elongation by collinear Wnt repression","volume":"4","author":"Denans","year":"2015","journal-title":"Elife"},{"key":"2022120816245149900_B61","doi-asserted-by":"publisher","first-page":"dev185298","DOI":"10.1242\/dev.185298","article-title":"Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development","volume":"147","author":"Ye","year":"2020","journal-title":"Development"},{"key":"2022120816245149900_B62","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1006\/dbio.2000.0104","article-title":"Expression of Hoxb13 and Hoxc10 in developing and regenerating axolotl limbs and tails","volume":"229","author":"Carlson","year":"2001","journal-title":"Dev. Biol."},{"key":"2022120816245149900_B63","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.devcel.2018.12.016","article-title":"The Lin28\/let-7 pathway regulates the mammalian caudal body axis elongation program","volume":"48","author":"Robinton","year":"2019","journal-title":"Dev. Cell."},{"key":"2022120816245149900_B64","doi-asserted-by":"publisher","first-page":"e88086","DOI":"10.1371\/journal.pone.0088086","article-title":"The heterochronic genes lin-28a and lin-28b play an essential and evolutionarily conserved role in early zebrafish development","volume":"9","author":"Ouchi","year":"2014","journal-title":"PLoS ONE"},{"key":"2022120816245149900_B65","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1242\/dev.120.4.1009","article-title":"no tail(ntl) is the zebrafish homologue of the mouse T(Brachyury) gene","volume":"120","author":"Schulte-Merker","year":"1994","journal-title":"Development"},{"key":"2022120816245149900_B66","doi-asserted-by":"publisher","first-page":"R215","DOI":"10.1016\/j.cub.2009.01.052","article-title":"Wnt signaling and the evolution of embryonic posterior development","volume":"19","author":"Martin","year":"2009","journal-title":"Curr. Biol."},{"key":"2022120816245149900_B67","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/343617a0","article-title":"Cloning of the T gene required in mesoderm formation in the mouse","volume":"343","author":"Herrmann","year":"1990","journal-title":"Nature"},{"key":"2022120816245149900_B68","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1101\/gad.8.2.174","article-title":"Wnt-3a regulates somite and tailbud formation in the mouse embryo","volume":"8","author":"Takada","year":"1994","journal-title":"Genes Dev."},{"key":"2022120816245149900_B69","doi-asserted-by":"publisher","first-page":"dev199408","DOI":"10.1242\/dev.199408","article-title":"Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression","volume":"148","author":"Ye","year":"2021","journal-title":"Development"},{"key":"2022120816245149900_B70","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s41467-021-27335-z","article-title":"Breaking constraint of mammalian axial formulae","volume":"13","author":"Hauswirth","year":"2022","journal-title":"Nat. Commun."},{"key":"2022120816245149900_B71","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1242\/dev.007567","article-title":"Hox patterning of the vertebrate rib cage","volume":"134","author":"McIntyre","year":"2007","journal-title":"Development"},{"key":"2022120816245149900_B72","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1242\/dev.128.10.1911","article-title":"Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes","volume":"128","author":"van den Akker","year":"2001","journal-title":"Development"},{"key":"2022120816245149900_B73","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1242\/dev.122.9.2651","article-title":"Function of posterior HoxD genes in the morphogenesis of the anal sphincter","volume":"122","author":"Kondo","year":"1996","journal-title":"Development"},{"key":"2022120816245149900_B74","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1242\/dev.122.4.1175","article-title":"A mutational analysis of the 5\u2032 HoxD genes: dissection of genetic interactions during limb development in the mouse","volume":"122","author":"Davis","year":"1996","journal-title":"Development"},{"key":"2022120816245149900_B75","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1002\/evl3.131","article-title":"Evolutionary lability in Hox cluster structure and gene expression in Anolis lizards","volume":"3","author":"Feiner","year":"2019","journal-title":"Evol. Lett."},{"key":"2022120816245149900_B76","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1016\/j.celrep.2019.07.089","article-title":"CRISPR-Cas9 gene editing in lizards through microinjection of unfertilized oocytes","volume":"28","author":"Rasys","year":"2019","journal-title":"Cell Rep."}],"container-title":["Essays in Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/essaysbiochem\/article-pdf\/66\/6\/717\/940428\/ebc-2022-0050c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/essaysbiochem\/article-pdf\/66\/6\/717\/940428\/ebc-2022-0050c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T16:25:08Z","timestamp":1670516708000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/essaysbiochem\/article\/66\/6\/717\/231623\/Shaping-Hox-gene-activity-to-generate"}},"subtitle":[],"editor":[{"given":"Alistair","family":"McGregor","sequence":"first","affiliation":[]},{"given":"Alexandra","family":"Buffry","sequence":"additional","affiliation":[]},{"given":"Renske","family":"Vroomans","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":76,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12,8]]},"published-print":{"date-parts":[[2022,12,8]]}},"URL":"https:\/\/doi.org\/10.1042\/ebc20220050","relation":{},"ISSN":["0071-1365","1744-1358"],"issn-type":[{"type":"print","value":"0071-1365"},{"type":"electronic","value":"1744-1358"}],"subject":[],"published-other":{"date-parts":[[2022,12]]},"published":{"date-parts":[[2022,12]]}}}