{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:42:09Z","timestamp":1791373329245,"version":"4.3.1"},"reference-count":20,"publisher":"American Speech Language Hearing Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Audiol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>This study compared clinical features, predisposing factors, and concomitant diseases between sporadic and familial M\u00e9ni\u00e8re's disease (MD).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>\n              Retrospective chart review and postal questionnaire were used. Participants were 250 definite patients with MD (sporadic,\n              <jats:italic>n<\/jats:italic>\n              =149; familial,\n              <jats:italic>n<\/jats:italic>\n              = 101) who fulfilled the American Academy of Otorhinolaryngology\u2013Head and Neck Surgery (1995) criteria.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              On average, familial patients were affected 5.6 years earlier than sporadic patients, and they suffered from significantly longer spells of vertigo (\n              <jats:italic>p<\/jats:italic>\n              = .007). The prevalence of rheumatoid arthritis (\n              <jats:italic>p<\/jats:italic>\n              = .002) and other autoimmune diseases (\n              <jats:italic>p<\/jats:italic>\n              = .046) was higher among the familial patients, who also had more migraine (\n              <jats:italic>p<\/jats:italic>\n              = .036) and hearing impairment (\n              <jats:italic>p<\/jats:italic>\n              = .002) in their families.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The clinical features of familial and sporadic MD are very similar in general, but some differences do exist. Familial MD patients are affected earlier and suffer from longer spells of vertigo.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Supplemental Material<\/jats:title>\n            <jats:p>\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.23641\/asha.14963505\">https:\/\/doi.org\/10.23641\/asha.14963505<\/jats:ext-link>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1044\/2014_aja-13-0060","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T10:31:36Z","timestamp":1395225096000},"page":"232-237","source":"Crossref","is-referenced-by-count":20,"title":["Higher Prevalence of Autoimmune Diseases and Longer Spells of Vertigo in Patients Affected With Familial M\u00e9ni\u00e8re's Disease: A Clinical Comparison of Familial and Sporadic M\u00e9ni\u00e8re's Disease"],"prefix":"10.1044","volume":"23","author":[{"given":"Elina","family":"Hietikko","sequence":"first","affiliation":[{"name":"Institute of Biomedicine, University of Oulu, Oulu, Finland"},{"name":"Oulu University Hospital, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martti","family":"Sorri","sequence":"additional","affiliation":[{"name":"Oulu University Hospital, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"M\u00e4nnikk\u00f6","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, University of Oulu, Oulu, Finland"},{"name":"Institute of Health Sciences, University of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouko","family":"Kotim\u00e4ki","sequence":"additional","affiliation":[{"name":"Central Hospital of Kainuu, Kajaani, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318216074a"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026759"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182091a41"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470015902.a0025161"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2013.03.010"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903382808"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2006.09.020"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.1.73"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2003.610112.x"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199905000-00013"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0149-2"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3180dca1cc"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002788"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-6519(06)78676-9"},{"key":"e_1_3_2_17_1","first-page":"CD008514","article-title":"Intratympanic steroids for M\u00e9ni\u00e8re's disease or syndrome","volume":"7","author":"Phillips J. 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