{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T22:21:53Z","timestamp":1747174913249,"version":"3.40.5"},"reference-count":47,"publisher":"American Speech Language Hearing Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Audiol"],"published-print":{"date-parts":[[2020,9,3]]},"abstract":"<jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Cannabis is widely used for medicinal and recreational purposes. Studies have evaluated its health benefits and consequences, although there is limited work on its effects on the auditory system. In this exploratory study, we evaluate the effects of cannabis smoking on early auditory evoked potentials.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>\n              We investigated auditory brainstem response (ABR) and electrocochleography waveforms in 18 cannabis smokers (44% women, 54% men;\n              <jats:italic>M<\/jats:italic>\n              <jats:sub>age<\/jats:sub>\n              = 23.06 years, range: 21\u201328 years) and 19 nonsmoker controls (63% women, 37% men;\n              <jats:italic>M<\/jats:italic>\n              <jats:sub>age<\/jats:sub>\n              = 23.74 years, range: 21\u201333 years). Threshold ABRs were recorded using rarefaction clicks at a rate of 17.7\/s from 80 dB nHL to Wave V threshold. Resulting amplitudes and latencies for Waves I, III, and V were compared via independent-samples\n              <jats:italic>t<\/jats:italic>\n              tests. Electrocochleograms obtained with 90 dB nHL (7.1\/s) alternating clicks were assessed for summating and compound action potentials, which were compared between groups using independent-samples\n              <jats:italic>t<\/jats:italic>\n              tests.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              ABR Wave I amplitudes were significantly lower in smokers (\n              <jats:italic>M<\/jats:italic>\n              = 0.14 \u03bcV,\n              <jats:italic>SD<\/jats:italic>\n              = 0.11) compared to nonsmokers (\n              <jats:italic>M<\/jats:italic>\n              = 0.21 \u03bcV,\n              <jats:italic>SD<\/jats:italic>\n              = 0.10,\n              <jats:italic>p<\/jats:italic>\n              = .039) at 80 dB nHL. Wave V latencies were significantly delayed in smokers at 80 dB nHL. Wave I and III latencies did not differ significantly between the two groups. Summating potential\/compound action potential ratios were significantly elevated in smokers (\n              <jats:italic>M<\/jats:italic>\n              = 0.30,\n              <jats:italic>SD<\/jats:italic>\n              = 0.04) versus nonsmokers (\n              <jats:italic>M<\/jats:italic>\n              = 0.21,\n              <jats:italic>SD<\/jats:italic>\n              = 0.05,\n              <jats:italic>p<\/jats:italic>\n              = .042).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We identified significant differences in electrophysiological outcomes between cannabis smokers and nonsmokers. Cannabis smoking may have a subtle neurotoxic effect on the auditory system. Larger confirmatory studies are warranted.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1044\/2020_aja-19-00065","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T19:17:50Z","timestamp":1591643870000},"page":"303-317","source":"Crossref","is-referenced-by-count":2,"title":["An Exploratory Study of Early Auditory Evoked Potentials in Cannabis Smokers"],"prefix":"10.1044","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9405-8438","authenticated-orcid":false,"given":"Rachael R.","family":"Baiduc","sequence":"first","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, University of Colorado Boulder"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mullervy","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, University of Colorado Boulder"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin M.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, University of Colorado Boulder"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Brumbach","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, University of Colorado Boulder"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashidhar","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, University of Colorado Boulder"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Vance","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, University of Colorado Boulder"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.5115\/acb.2014.47.3.162"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992020903019338"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_JSLHR-H-18-0361"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-018-0669-5"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.21.1715"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-014-0461-0"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199001000-00005"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.423293"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1808-86942009000300018"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00164.2013"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.17712\/nsj.2015.3.20150105"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joto.2017.04.005"},{"key":"e_1_3_2_15_1","first-page":"175","volume-title":"Auditory electrophysiology: A clinical guide","author":"Henderson C. 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