{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:45:57Z","timestamp":1760985957345,"version":"3.40.5"},"reference-count":46,"publisher":"American Speech Language Hearing Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Audiol"],"published-print":{"date-parts":[[2020,12,9]]},"abstract":"<jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>The study investigated whether the auditory brainstem response (ABR) at a baseline and at higher repetition rates can detect if neurodegeneration has occurred in adults living with HIV who present with normal behavioral pure-tone thresholds.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>\n              An exploratory research design was used. Forty adults with HIV (80 ears, 57.5% female;\n              <jats:italic>M<\/jats:italic>\n              <jats:sub>age<\/jats:sub>\n              = 26.3 years,\n              <jats:italic>SD<\/jats:italic>\n              = 3.68) and 20 adults without HIV participated. Phase 1 compared ABR absolute and interwave latencies at a baseline rate. Phase 2 examined the effect of HIV status and category of immunodeficiency on ABR absolute Wave V latency and Wave V latency shift at increased stimulus rates. Analysis included a two-way analysis of variance of the interaction between stimulus rate and HIV status and between CD4+ category and rate, and multiple regression analysis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In adults living with HIV, the baseline ABR yielded prolonged Wave III and V absolute latencies and interpeak prolongations in 22.5%. Interaural Wave V latency differences were present in 15% of participants. An additional 15% of ears presented with abnormal Wave V at increased rates.<\/jats:p>\n            <jats:p>\n              No significant interaction between HIV status and rate in either ear or between CD4+ category and rate was found in either ear (\n              <jats:italic>p<\/jats:italic>\n              &gt; .05). Although rate and gender contributed significantly to the prediction of Wave V latency of the rate study (left and right,\n              <jats:italic>p<\/jats:italic>\n              &lt; .001), HIV status did not (left and right,\n              <jats:italic>p<\/jats:italic>\n              &gt; .05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Although the interaction of HIV status and CD4+ with rate was not significant, more ears were identified with abnormal results at increased stimulus rates than with the baseline ABR alone. The ABR at increased rates may therefore be a valuable addition for the identification of individuals living with HIV with auditory neural deficiencies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1044\/2020_aja-19-00125","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T12:00:16Z","timestamp":1602158416000},"page":"873-886","source":"Crossref","is-referenced-by-count":2,"title":["Auditory Brainstem Response Test at Different Stimulus Rates in Normal-Hearing Adults Living With HIV"],"prefix":"10.1044","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-9120","authenticated-orcid":false,"given":"Adriana","family":"De Necker","sequence":"first","affiliation":[{"name":"Department of Speech-Language Pathology and Audiology, University of Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-8626","authenticated-orcid":false,"given":"Leigh","family":"Biagio-de Jager","sequence":"additional","affiliation":[{"name":"Department of Speech-Language Pathology and Audiology, University of Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-0772","authenticated-orcid":false,"given":"Anton Carel","family":"Stoltz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Steve Biko Academic Hospital, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1310","reference":[{"unstructured":"Ackley S. 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