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The prevalence rate of ASD in DS is ~20%, which is higher than in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This clinical focus article aims to provide SLPs with additional knowledge about DS + ASD to improve service delivery and support parents' ability to advocate for their child with confirmed or suspected DS + ASD. This is accomplished by summarizing the current evidence base on the presence of ASD in DS and discussing implications of a DS + ASD diagnosis for clinical practice with SLPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SLPs play a key role in supporting families of those with DS + ASD by advocating and educating. 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