{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:27:12Z","timestamp":1794108432476,"version":"4.8.0"},"reference-count":48,"publisher":"American Speech Language Hearing Association","issue":"3S","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Speech Lang Pathol"],"published-print":{"date-parts":[[2021,6,18]]},"abstract":"<jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>This study describes motor speech disorders and associated communication limitations in six variants of progressive supranuclear palsy (PSP).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>\n              The presence, nature, and severity of dysarthria and apraxia of speech (AOS) were documented, along with scores on the Apraxia of Speech Rating Scale\u2013Version 3 (ASRS-3) for 77 (40 male and 37 female) patients with PSP. Clinician-estimated and patient-estimated communication limitations were rated using the Motor Speech Disorders Severity Rating (MSDSR) Scale and the Communicative Effectiveness Survey (CES), respectively. Descriptive statistics were calculated for each of these dependent variables. One-tailed\n              <jats:italic>t<\/jats:italic>\n              tests were conducted to test mean differences in ASRS-3 and CES between participants with and without AOS and between participants with and without dysarthria. Spearman rank correlations were calculated between ASRS-3 scores and clinical judgments of AOS and dysarthria severity and between MSDSR and CES ratings.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Nine participants (12%) had normal speech. Eighty-seven percent exhibited dysarthria; hypokinetic and mixed hypokinetic\u2013spastic dysarthria were observed most frequently. AOS was observed in 19.5% of participants across all variants, but in only 10% exclusive of the PSP speech and language variant. Nearly half presented with AOS in which neither phonetic nor prosodic features clearly predominated. The mean ASRS-3 score for participants with AOS was significantly higher than for those without and correlated strongly with clinician judgment of AOS severity. Mean ASRS-3 was higher for participants with dysarthria than for those without but correlated weakly with dysarthria severity. Mean MSDSR and CES ratings were lower in participants with AOS compared to those without and moderately correlated with each other.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Motor speech disorders that negatively impact communicative effectiveness are common in PSP and occur in many variants. This is the first description of motor speech disorders across PSP variants, setting the stage for future research characterizing neuroanatomical correlates, progression of motor speech disorders, and benefits of targeted interventions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Supplemental Material<\/jats:title>\n            <jats:p>\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.23641\/asha.14111837\">https:\/\/doi.org\/10.23641\/asha.14111837<\/jats:ext-link>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1044\/2020_ajslp-20-00126","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T02:51:50Z","timestamp":1615344710000},"page":"1361-1372","source":"Crossref","is-referenced-by-count":23,"title":["Motor Speech Disorders and Communication Limitations in Progressive Supranuclear Palsy"],"prefix":"10.1044","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-0084","authenticated-orcid":false,"given":"Heather M.","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9519-1302","authenticated-orcid":false,"given":"Rene L.","family":"Utianski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farwa","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-685X","authenticated-orcid":false,"given":"Hugo","family":"Botha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8074-6587","authenticated-orcid":false,"given":"Jennifer L.","family":"Whitwell","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-8634","authenticated-orcid":false,"given":"Keith A.","family":"Josephs","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6839-9"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1489241"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27619"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009211"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2012\/12-0140)"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.02.036"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170743"},{"key":"e_1_3_2_9_1","first-page":"100","article-title":"Motor speech disorders accompanying RS and SL variants of progressive supanuclear palsy","volume":"22","author":"Clark H. 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