{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:54:20Z","timestamp":1778903660705,"version":"3.51.4"},"reference-count":93,"publisher":"American Speech Language Hearing Association","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Speech Lang Hear Res"],"published-print":{"date-parts":[[2020,12,14]]},"abstract":"<jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Specific language impairment (SLI) is characterized by a delay in language acquisition despite a lack of other developmental delays or hearing loss. Genetics of SLI is poorly understood. The purpose of this study is to identify SLI genetic loci through family-based linkage mapping.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>We performed genome-wide parametric linkage analysis in six families segregating with SLI. An age-appropriate standardized omnibus language measure was used to categorically define the SLI phenotype.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              A suggestive linkage region replicated a previous region of interest with the highest logarithm of odds (LOD) score of 2.40 at 14q11.2-q13.3 in Family 489. A paternal parent-of-origin effect associated with SLI and language phenotypes on a nonsynonymous single nucleotide polymorphism (SNP) in\n              <jats:italic>NOP9<\/jats:italic>\n              (14q12) was reported previously. Linkage analysis identified a new SLI locus at 15q24.3-25.3 with the highest parametric LOD score of 3.06 in Family 315 under a recessive mode of inheritance. Suggestive evidence of linkage was also revealed at 4q31.23-q35.2 in Family 300, with the highest LOD score of 2.41. Genetic linkage was not identified in the other three families included in parametric linkage analysis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These results are the first to report genome-wide suggestive linkage with a total language standard score on an age-appropriate omnibus language measure across a wide age range. Our findings confirm previous reports of a language-associated locus on chromosome 14q, report new SLI loci, and validate the pedigree-based parametric linkage analysis approach to mapping genes for SLI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Supplemental Material<\/jats:title>\n            <jats:p>\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.23641\/asha.13203218\">https:\/\/doi.org\/10.23641\/asha.13203218<\/jats:ext-link>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1044\/2020_jslhr-20-00102","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T23:01:50Z","timestamp":1605308510000},"page":"4046-4061","source":"Crossref","is-referenced-by-count":12,"title":["Pedigree-Based Gene Mapping Supports Previous Loci and Reveals Novel Suggestive Loci in Specific Language Impairment"],"prefix":"10.1044","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-6728","authenticated-orcid":false,"given":"Erin M.","family":"Andres","sequence":"first","affiliation":[{"name":"Child Language Doctoral Program, University of Kansas, Lawrence"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen Kelsey","family":"Earnest","sequence":"additional","affiliation":[{"name":"Language Acquisition Studies Lab, University of Kansas, Lawrence"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, University of Nebraska Medical Center, Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8150-5523","authenticated-orcid":false,"given":"Mabel L.","family":"Rice","sequence":"additional","affiliation":[{"name":"Child Language Doctoral Program, University of Kansas, Lawrence"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-5195","authenticated-orcid":false,"given":"Muhammad Hashim","family":"Raza","sequence":"additional","affiliation":[{"name":"Child Language Doctoral Program, University of Kansas, Lawrence"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng786"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/302536"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2372732219839075"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-019-0398-1"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334381"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077385"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/341095"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2005.00148.x"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00360.x"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1995.tb11932.x"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/36849"},{"key":"e_1_3_2_13_1","volume-title":"The Columbia Mental Maturity Scale","author":"Burgemeister B. 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