{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:37:28Z","timestamp":1792471048696,"version":"4.5.0"},"reference-count":47,"publisher":"American Speech Language Hearing Association","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Speech Lang Hear Res"],"published-print":{"date-parts":[[2020,11,13]]},"abstract":"<jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Dysphagia is a serious extra pulmonary manifestation of chronic obstructive pulmonary disease (COPD). However, the nature of abnormalities in swallowing physiology in COPD has yet to be clearly established. We explored the frequency of swallowing measures outside the healthy reference range in adults with COPD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>\n              Participants were 28 adults aged 41\u201379 years (18 men, 20 women) with stable COPD. Disease severity was classified as GOLD (Global Initiative For Chronic Obstructive Lung Disease) Stages 1 (4%), 2 (25%), 3 (53%), and 4 (18%). Participants underwent a videofluoroscopy and swallowed 20% w\/v thin barium in, followed by 20% w\/v mildly, moderately, and extremely thick barium prepared with a xanthan gum thickener. Blinded duplicate ratings of swallowing safety, efficiency, kinematics, and timing were performed according to the ASPEKT method (Analysis of Swallowing Physiology: Events, Kinematics and Timing). Comparison data for healthy adults aged &lt; 60 years were extracted from an existing data set. Chi-square and Fisher's exact tests compared the frequencies of measures falling &lt; 1\n              <jats:italic>SD<\/jats:italic>\n              \/ &gt; 1\n              <jats:italic>SD<\/jats:italic>\n              from mean reference values (or &lt; the first or &gt; the third quartile for skewed parameters).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              Participants with COPD did not display greater frequencies of penetration\u2013aspiration, but they were significantly more likely (\n              <jats:italic>p<\/jats:italic>\n              &lt; .05) to display incomplete laryngeal vestibule closure (LVC), longer time-to-LVC, and shorter LVC duration. They also displayed significantly higher frequencies of short upper esophageal sphincter opening, reduced pharyngeal constriction, and pharyngeal residue.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This analysis reveals differences in swallowing physiology in patients with stable COPD characterized by impaired safety related to the mechanism, timing, and duration of LVC and by impaired swallowing efficiency with increased pharyngeal residue related to poor pharyngeal constriction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1044\/2020_jslhr-20-00154","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T23:15:05Z","timestamp":1603754105000},"page":"3643-3658","source":"Crossref","is-referenced-by-count":34,"title":["Quantitative Videofluoroscopic Analysis of Swallowing Physiology and Function in Individuals With Chronic Obstructive Pulmonary Disease"],"prefix":"10.1044","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-7508","authenticated-orcid":false,"given":"Renata","family":"Mancopes","sequence":"first","affiliation":[{"name":"The KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada"},{"name":"Dysphagia Laboratory, Graduate Program of Human Communication Disorders, Federal University of Santa Maria, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Peladeau-Pigeon","sequence":"additional","affiliation":[{"name":"The KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Barrett","sequence":"additional","affiliation":[{"name":"The KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Guran","sequence":"additional","affiliation":[{"name":"The KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-7585","authenticated-orcid":false,"given":"Sana","family":"Smaoui","sequence":"additional","affiliation":[{"name":"The KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada"},{"name":"Rehabilitation Sciences Institute, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriane Schmidt","family":"Pasqualoto","sequence":"additional","affiliation":[{"name":"Dysphagia Laboratory, Graduate Program of Human Communication Disorders, Federal University of Santa Maria, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4294-6561","authenticated-orcid":false,"given":"Catriona M.","family":"Steele","sequence":"additional","affiliation":[{"name":"The KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Ontario, Canada"},{"name":"Dysphagia Laboratory, Graduate Program of Human Communication Disorders, Federal University of Santa Maria, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1044\/2020_JSLHR-19-00220"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_AJSLP-19-00095"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-007-9077-4"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.2.9612089"},{"issue":"1","key":"e_1_3_2_6_1","first-page":"489","article-title":"Oral and pharyngeal bolus transit in patients with chronic obstructive pulmonary disease","volume":"10","author":"Cassiani R. A.","year":"2015","journal-title":"International Journal of Chronic Obstructive Pulmonary Disease"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2008.008170"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-62"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/17549507.2014.882987"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10014-z"},{"issue":"2","key":"e_1_3_2_11_1","first-page":"289","article-title":"Laryngeal penetration and aspiration in individuals with stable COPD","volume":"27","author":"Cvejic L.","year":"2011","journal-title":"Dysphagia"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00009520"},{"issue":"2","key":"e_1_3_2_13_1","first-page":"161","article-title":"Manifesta\u00e7\u00f5es sist\u00eamicas na doen\u00e7a pulmonar obstrutiva cr\u00f4nica [The English translations of the manuscript title and journal title are: Systemic Manifestations in Chronic Obstructive Pulmonary Disease]","volume":"32","author":"Dourado V. Z.","year":"2006","journal-title":"Brazilian Journal of Pulmonology"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S165657"},{"key":"e_1_3_2_15_1","unstructured":"Global Initiative For Chronic Obstructive Lung Disease. (2020). Global strategy for the diagnosis management and prevention of chronic obstructive pulmonary disease. \nhttps:\/\/goldcopd.org\/wp-content\/uploads\/2019\/12\/GOLD-2020-FINAL-ver1.2-03Dec19_WMV.pdf"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9924(99)00026-X"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-019-02308-y"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1044\/2017_JSLHR-S-16-0117"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_JSLHR-19-00169"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1044\/2018_JSLHR-S-17-0417"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90290-9"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.084715"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-010-9312-2"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-009-9258-4"},{"issue":"3","key":"e_1_3_2_25_1","first-page":"274","article-title":"Clinical and fiberoptic endoscopic assessment of swallowing in patients with chronic obstructive pulmonary disease","volume":"17","author":"Macri M. R.","year":"2013","journal-title":"International Archives of Otorhinolaryngology"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-008-9185-9"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00806.2002"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.11.022"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198704000-00014"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-018-9924-5"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2017-000202"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.10.023"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24408"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2016.001"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-009-9237-9"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1044\/sasd24.3.115"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417897"},{"key":"e_1_3_2_38_1","first-page":"258","article-title":"Timing plays a major role in the pathophysiology of aspiration","volume":"31","author":"Steele C. M.","year":"2015","journal-title":"Dysphagia"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_JSLHR-S-18-0448"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1044\/2020_AJSLP-20-00042"},{"issue":"1","key":"e_1_3_2_41_1","first-page":"74","article-title":"Relationship between dysphagia and exacerbations in chronic obstructive pulmonary disease: A literature review","volume":"19","author":"Steidl E.","year":"2015","journal-title":"International Archives of Otorhinolaryngology"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-015-9606-5"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0482"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-775720140132"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-018-9928-1"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1044\/2020_JSLHR-19-00051"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-018-9904-9"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150131912443827"}],"container-title":["Journal of Speech, Language, and Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asha.org\/doi\/pdf\/10.1044\/2020_JSLHR-20-00154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T03:50:54Z","timestamp":1618804254000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.asha.org\/doi\/10.1044\/2020_JSLHR-20-00154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11,13]]}},"alternative-id":["10.1044\/2020_JSLHR-20-00154"],"URL":"https:\/\/doi.org\/10.1044\/2020_jslhr-20-00154","relation":{},"ISSN":["1092-4388","1558-9102"],"issn-type":[{"value":"1092-4388","type":"print"},{"value":"1558-9102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]}}}