{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:48:32Z","timestamp":1760986112000,"version":"3.40.5"},"reference-count":42,"publisher":"American Speech Language Hearing Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Audiol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>In this exploratory, open-label study, we used behavioral and brain imaging measures to assess the effectiveness of a smartphone application (ReSound Relief app), which aims to help reduce tinnitus-related distress.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method:<\/jats:title>\n            <jats:p>Fourteen participants with a wide range of tinnitus-related symptoms and who were not currently undergoing any external treatment participated. They completed the 6-month study and reported different levels of engagement with the app.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Across a range of tinnitus questionnaires, most participants showed either no change or decrease in tinnitus handicap. Resting-state and task-based functional magnetic resonance imaging (fMRI) data were collected at baseline and the end of the study. Resting-state fMRI of 12 participants revealed alterations in interregional connectivity of default mode, salience, emotion, auditory, and visual processing networks at the end of the intervention period compared to baseline. Ratings of affective sounds (as pleasant, neutral, or unpleasant) were assessed using fMRI, and comparison after 6 months of app usage revealed reduced activity in the left superior temporal gyrus (secondary auditory cortex), right superior occipital gyrus, and left posterior cingulate cortex. Our findings were not significant at a false discovery rate level of\n              <jats:italic>p<\/jats:italic>\n              &lt; .05.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The reported changes were not significant, possibly due to the small sample size, heterogeneity of the tinnitus handicap among subjects at the start of the project, and the length of the intervention period. Nevertheless, this study underscores the ease of usage of the app and the potential use of brain imaging to assess changes due to a passive, self-administered intervention for individuals with varying levels of tinnitus severity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1044\/2022_aja-21-00170","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T18:31:08Z","timestamp":1656354668000},"page":"633-645","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating the Efficacy of a Smartphone App for Tinnitus Relief Using Behavioral and Brain Imaging Measures"],"prefix":"10.1044","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5878-3851","authenticated-orcid":false,"given":"Fatima T.","family":"Husain","sequence":"first","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana\u2013Champaign, Urbana"},{"name":"Department of Speech and Hearing Science, University of Illinois at Urbana\u2013Champaign, Champaign"},{"name":"Neuroscience Program, University of Illinois at Urbana\u2013Champaign, Urbana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafay A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana\u2013Champaign, Urbana"},{"name":"Neuroscience Program, University of Illinois at Urbana\u2013Champaign, Urbana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihsin","family":"Tai","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana\u2013Champaign, Urbana"},{"name":"Department of Speech and Hearing Science, University of Illinois at Urbana\u2013Champaign, Champaign"},{"name":"Department of Speech Pathology and Audiology, Ball State University, Muncie, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Shahsavarani","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana\u2013Champaign, Urbana"},{"name":"Department of Speech and Hearing Science, University of Illinois at Urbana\u2013Champaign, Champaign"},{"name":"Neuroscience Program, University of Illinois at Urbana\u2013Champaign, Urbana"},{"name":"Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","unstructured":"American National Standards Institute. (2003). Maximum permissible ambient noise levels for audiometric test rooms (ANSI S3.1-1999 [R2003])."},{"key":"e_1_3_2_3_1","unstructured":"American National Standards Institute. (2010). Specification for audiometers (ANSI S3.6-2004)."},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(88)90050-5"},{"key":"e_1_3_2_6_1","unstructured":"Bradley M. M. & \nLang P. J.\n (2007). The International Affective Digitized Sounds (IADS-2): Affective ratings of sounds and instruction manual (Tech. Rep. B-3). University of Florida."},{"key":"e_1_3_2_7_1","unstructured":"Brett M. Anton J. L. Valabregue R. & \nPoline J. B.\n (2002). Region of interest analysis using an SPM toolbox. In 8th International Conference on Functional Mapping of the Human Brain (Vol. 16 No. 2 p. 497)."},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-13-3"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.04.024"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/161478"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144419"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199908000-00004"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.06.004"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.09.010"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.05.010"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2013.07.010"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_AJA-TTR17-18-0039"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1722984"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.2466\/11.IT.3.1"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1784440"},{"issue":"12","key":"e_1_3_2_21_1","first-page":"10","article-title":"MarkeTrak VIII: The prevalence of tinnitus in the United States and the self-reported efficacy of various treatments","volume":"18","author":"Kochkin S.","year":"2011","unstructured":"Kochkin, S. , Tyler, R. , & Born, J. (2011). MarkeTrak VIII: The prevalence of tinnitus in the United States and the self-reported efficacy of various treatments. Hearing Review, 18(12), 10\u201326.","journal-title":"Hearing Review"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00384"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036222"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.05.009"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.2196\/21767"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e31822f67c0"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890140029007"},{"issue":"2","key":"e_1_3_2_28_1","first-page":"153","article-title":"Psychometric adequacy of the Tinnitus Handicap Inventory (THI) for evaluating treatment outcome","volume":"9","author":"Newman C. W.","year":"1998","unstructured":"Newman, C. W. , Sandridge, S. A. , & Jacobson, G. P. (1998). Psychometric adequacy of the Tinnitus Handicap Inventory (THI) for evaluating treatment outcome. Journal of the American Academy of Audiology, 9(2), 153\u2013160.","journal-title":"Journal of the American Academy of Audiology"},{"key":"e_1_3_2_29_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2019","unstructured":"R Core Team. (2019). R: A language and environment for statistical computing. R Foundation for Statistical Computing. https:\/\/www.R-project.org\/"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815571556"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076488"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.07.015"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_PERS-SIG6-2019-0001"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147277"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814545325"},{"key":"e_1_3_2_36_1","first-page":"1","volume-title":"Tinnitus treatment: Clinical protocols","author":"Tyler R. S.","year":"2006","unstructured":"Tyler, R. S. (2006). Neurophysiological models, psychological models, and treatments for tinnitus. In R. S. Tyler (Ed.), Tinnitus treatment: Clinical protocols (Chap. 1, 1\u201322). Thieme"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1044\/2014_AJA-13-0014"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/03655230600895424"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)66048-8"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1044\/2018_AJA-17-0105"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811403882"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00747"}],"container-title":["American Journal of Audiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asha.org\/doi\/pdf\/10.1044\/2022_AJA-21-00170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T18:12:32Z","timestamp":1662055952000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.asha.org\/doi\/10.1044\/2022_AJA-21-00170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1044\/2022_AJA-21-00170"],"URL":"https:\/\/doi.org\/10.1044\/2022_aja-21-00170","relation":{},"ISSN":["1059-0889","1558-9137"],"issn-type":[{"type":"print","value":"1059-0889"},{"type":"electronic","value":"1558-9137"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}