{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:01:41Z","timestamp":1789398101691,"version":"build-2803163510"},"reference-count":50,"publisher":"American Speech Language Hearing Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Audiol"],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Persons with cystic fibrosis (PwCF) are at high risk for ototoxicity due to the routine use of intravenous aminoglycoside (IV-AG) antibiotics in respiratory infection management. Additionally, factors that contribute to ototoxicity-related symptom development and severity in PwCF are unknown. Given the increased risk of ototoxicity in people with diabetes, we explored the association between cystic fibrosis\u2013related diabetes (CFRD) and self-reported ototoxicity symptoms (tinnitus and vestibular problems) in PwCF treated with aminoglycosides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      PwCF (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 39; 25 females, 14 males;\n                      <jats:italic toggle=\"yes\">M<\/jats:italic>\n                      <jats:sub>age<\/jats:sub>\n                      = 30.1 years,\n                      <jats:italic toggle=\"yes\">SD<\/jats:italic>\n                      = 10.3) were recruited from the Cystic Fibrosis Care Center at Oregon Health &amp; Science University. Patients completed the validated questionnaires to ascertain their experiences with ototoxicity-related symptoms of tinnitus and balance function. The diagnosis of CFRD, including oral glucose tolerance testing (OGTT), insulin treatment, hemoglobin A1c, and cumulative IV-AG treatment history, was obtained through a medical chart review. Participants were classified into three groups based on their medical diagnoses via OGTT: normal glucose tolerance (NGT; control;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 16), abnormal glucose tolerance (AGT;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 9), and CFRD (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 14). Participants in each group were further classified based on survey outcomes for ototoxicity-related symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was a trend toward a higher proportion of patients with CFRD reporting tinnitus compared to the AGT and NGT groups, but did not meet statistical significance (\n                      <jats:italic toggle=\"yes\">X<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 2.24,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .13). Approximately, 43% of patients with CFRD reported experiencing clinically significant tinnitus lasting &gt; 3 min compared to 11% in the AGT group and 13% in the NGT group (\n                      <jats:italic toggle=\"yes\">X<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 3.751,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .05). Cumulative IV-AG exposure tended to be higher in CFRD compared to other groups. High balance function was generally reported in all groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with CFRD have greater ototoxicity-related symptoms. Further investigation of the relationship between CF-related comorbidities and the risk of developing ototoxicity-related symptoms is warranted to improve the detection and management of ototoxicity in PwCF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1044\/2023_aja-22-00237","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T17:22:32Z","timestamp":1701192152000},"page":"283-291","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Observations in Patients With Cystic Fibrosis\u2013Related Diabetes and Self-Reported Ototoxicity Symptoms"],"prefix":"10.1044","volume":"33","author":[{"given":"Nicole","family":"Nichols","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Oregon Health &amp; Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Rubenstein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay J.","family":"Vachhani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Oregon Health &amp; Science University, Portland"},{"name":"VA Portland Health Care System, National Center for Rehabilitative Auditory Research, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Vida","family":"Echaluse","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Oregon Health &amp; Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6088-6603","authenticated-orcid":false,"given":"Angela Constance","family":"Garinis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Oregon Health &amp; Science University, Portland"},{"name":"VA Portland Health Care System, National Center for Rehabilitative Auditory Research, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20570"},{"key":"e_1_3_2_3_1","doi-asserted-by":"crossref","first-page":"eS8","DOI":"10.1016\/S0929-693X(20)30044-0","article-title":"CFTR gene variants, epidemiology and molecular pathology","volume":"27","author":"Bareil C.","year":"2020","unstructured":"Bareil, C., & Bergougnoux, A. 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