{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:12:09Z","timestamp":1756858329465,"version":"3.44.0"},"reference-count":38,"publisher":"American Speech Language Hearing Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Audiol"],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>This study aims to explore the presence of contralateral suppression of otoacoustic emissions (CS-OAEs) in unilateral cochlear implant (CI) users with auditory neuropathy spectrum disorder (ANSD).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method:<\/jats:title>\n            <jats:p>We enrolled three unilateral CI users with bilateral ANSD and stable otoacoustic emissions in the nonimplanted ear, exhibiting diverse postsynaptic ANSD backgrounds including cerebellar ataxia, areflexia, pes cavus, optic atrophy, sensorineural hearing loss syndrome, Optic Atrophy Plus Syndrome, and Spinocerebellar Ataxia. Measurements of transient-evoked otoacoustic emissions (TEOAEs) were conducted both with and without contralateral electrical stimulation (CES) across five frequency bands. CES was delivered via a CI using a direct audio input cable connected to a computer. In order to elicit a response, broad-band noise is applied and presented at a comfortable level.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Minor amplitude reductions (between 0.2 and 0.6 dB SPL) were observed in TEOAEs with CES across different frequencies for each subject. Despite these changes, there was no prominent suppression effect observed, which emphasizes the differences in CS-OAE responses among individuals with postsynaptic ANSD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The absence of significant CS-OAE suppression suggests that direct electrical stimulation through CES may not consistently engage the efferent auditory system in patients with postsynaptic ANSD characteristics. It is essential to broaden the study population to encompass a more diverse range of ANSD presentations in order to confirm the effectiveness of CES in stimulating efferent pathways.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1044\/2025_aja-24-00199","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T21:17:43Z","timestamp":1753132663000},"page":"734-741","source":"Crossref","is-referenced-by-count":0,"title":["Is Contralateral Suppression of Otoacoustic Emission Observable in Unilateral Cochlear Implant Users With Auditory Neuropathy Spectrum Disorder?"],"prefix":"10.1044","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-6404","authenticated-orcid":false,"given":"At\u0131l\u0131m","family":"At\u0131lgan","sequence":"first","affiliation":[{"name":"Department of Audiology, Istanbul Medeniyet University Faculty of Health Sciences, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-4053","authenticated-orcid":false,"given":"H\u00fcsna","family":"Yoktan Talay","sequence":"additional","affiliation":[{"name":"Audiology\u2014Speech and Language Disorders Unit, Istanbul University Faculty of Medicine, T\u00fcrkiye"},{"name":"Department of Audiology and Speech Disorders, Marmara University Institute of Health Sciences, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9092-7541","authenticated-orcid":false,"given":"Mustafa","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Audiology, Ankara Medipol University School of Health Sciences, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0295-8760","authenticated-orcid":false,"given":"Ay\u00e7a","family":"\u00c7iprut","sequence":"additional","affiliation":[{"name":"Department of Audiology, Marmara University Faculty of Medicine, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199902000-00005"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-200012000-00002"},{"key":"e_1_3_2_4_1","volume-title":"American national standard: Maximum permissible ambient noise levels for audiometric test rooms","author":"American National Standards Institute","year":"1999","unstructured":"American National Standards Institute. 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