{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:53:34Z","timestamp":1791921214999,"version":"4.3.4"},"reference-count":60,"publisher":"American Speech Language Hearing Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Speech Lang Hear Res"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The purpose of this study was to identify and describe extrapulmonary cough receptors located in healthy individuals' larynges and pharynges and the types of stimuli to which they are sensitive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>This scoping review was registered in the Open Science Framework. The review followed the Joanna Briggs Institute methodology and was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. The search was performed electronically in the LILACS, Scopus, manually in gray literature (Google Scholar, MedRxiv, and ProQuest), and by mapping citations and consulting experts. The search was initiated in August 2024. The review included primary studies describing laryngeal and\/or pharyngeal cough receptors in healthy human individuals. The data were analyzed descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The search found 12 studies on extrapulmonary cough receptors, all describing laryngeal and seven of them also pharyngeal ones. Only rapidly adapting receptors (RARs) with myelinated fibers were reported in both regions, responding predominantly to mechanical stimuli. The locations of the receptors, when described, are not uniform, with epithelium and mucosa being possible sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Data on the location of extrapulmonary cough receptors in healthy individuals are heterogeneous. RARs that respond mainly to mechanical stimuli predominate in these regions and conduct stimuli to the nerve centers through myelinated fibers to trigger cough. However, the small number of included studies and variability in anatomical descriptions limit definitive conclusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1044\/2026_jslhr-26-00206","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:43:01Z","timestamp":1791920581000},"page":"1-15","source":"Crossref","is-referenced-by-count":0,"title":["Mapping Cough Receptors in the Larynx and Pharynx in Healthy Individuals: A Scoping Review"],"prefix":"10.1044","author":[{"given":"Luciane Teixeira","family":"Soares","sequence":"first","affiliation":[{"name":"Centro de Estudos da Voz, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Castelli","family":"Silv\u00e9rio","sequence":"additional","affiliation":[{"name":"Centro de Estudos da Voz, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-5751","authenticated-orcid":false,"given":"Rodrigo","family":"Dornelas","sequence":"additional","affiliation":[{"name":"Centro de Estudos da Voz, S\u00e3o Paulo, Brazil"},{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-6085","authenticated-orcid":false,"given":"Vanessa Veis","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro de Estudos da Voz, S\u00e3o Paulo, Brazil"},{"name":"Universidade Federal de Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Behlau","sequence":"additional","affiliation":[{"name":"Centro de Estudos da Voz, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1310","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"4","key":"e_1_3_2_2_1","first-page":"477","article-title":"Cough, a vital reflex: Mechanisms, determinants and measurements","volume":"89","author":"Andrani F.","year":"2019","unstructured":"Andrani, F., Aiello, M., Bertorelli, G., Crisafulli, E., & Chetta, A. (2019). Cough, a vital reflex: Mechanisms, determinants and measurements. Acta Bio Medica Atenei Parmensis, 89(4), 477\u2013480. https:\/\/doi.org\/10.23750\/abm.v89i4.6182","journal-title":"Acta Bio Medica Atenei Parmensis"},{"key":"e_1_3_2_3_1","article-title":"JBI manual for evidence synthesis","author":"Aromataris E.","year":"2024","unstructured":"Aromataris, E., Lockwood, C., Porritt, K., Pilla, B., & Jordan, Z. (Eds.). (2024). JBI manual for evidence synthesis. JBI. https:\/\/doi.org\/10.46658\/JBIMES-24-01","journal-title":"JBI"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.20473\/jr.v6-I.3.2020.85-96"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.7162\/S1809-97772012000200016"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-023-03556-1"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-3327"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.02.006"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-1082-1"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1_suppl.33S"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1481"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199907)28:1<59::AID-PPUL10>3.0.CO;2-Y"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2005.11.009"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/1982-0216201517013"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-016-0557-1"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0086OC"},{"issue":"6","key":"e_1_3_2_17_1","article-title":"Carcinoma ex pleomorphic adenoma: A review of incidence, demographics, risk factors, and survival","volume":"40","author":"Dhillon V. K.","year":"2019","unstructured":"Dhillon, V. K., Akst, L. M., & Hillel, A. T. (2019). Carcinoma ex pleomorphic adenoma: A review of incidence, demographics, risk factors, and survival. American Journal of Otolaryngology, 40(6), Article 102279. https:\/\/doi.org\/10.1016\/j.amjoto.2019.102279","journal-title":"American Journal of Otolaryngology"},{"issue":"1","key":"e_1_3_2_18_1","article-title":"Chronic cough and speech therapy","volume":"34","author":"Dornelas R.","year":"2022","unstructured":"Dornelas, R., Ribeiro, V. V., & Behlau, M. (2022). Chronic cough and speech therapy. CoDAS, 34(1), Article e20210127. https:\/\/doi.org\/10.1590\/2317-1782\/20212021127","journal-title":"CoDAS"},{"issue":"3","key":"e_1_3_2_19_1","first-page":"1","article-title":"Definition, epidemiology and basic pathophysiologic mechanisms","volume":"14","author":"Erdin\u00e7 M.","year":"2013","unstructured":"Erdin\u00e7, M. (2013). Definition, epidemiology and basic pathophysiologic mechanisms. Turkish Thoracic Journal, 14(3), 1\u20135. https:\/\/doi.org\/10.5152\/ttd.2013.100","journal-title":"Turkish Thoracic Journal"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1044\/2020_JSLHR-20-00350"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2.482"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.063"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-009-9201-3"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2010.11.002"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480802273108"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(97)01040-9"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1.1"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(06)80254-4"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2022.09.021"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2006.11.010"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-023-00659-x"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2004.09.021"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-1-2"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2003"},{"key":"e_1_3_2_35_1","first-page":"49","article-title":"Role of the histamine H4-receptor in bronchial asthma","volume":"241","author":"Mazzone S. B.","year":"2016","unstructured":"Mazzone, S. B., & Undem, B. J. (2016). Role of the histamine H4-receptor in bronchial asthma. In Y. Hattori & R. Seifert (Eds.), Handbook of experimental pharmacology: Histamine and histamine receptors in health and disease (vol. 241, pp. 49\u201363). https:\/\/doi.org\/10.1007\/164_2016_11","journal-title":"Handbook of experimental pharmacology: Histamine and histamine receptors in health and disease"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21427"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-009-9185-z"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00101006"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.09.006"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.3.9707158"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_3_2_42_1","doi-asserted-by":"crossref","unstructured":"Poliacek I. (2020). Sensory pathways and neural modulation of cough. In A. Zanasi G. Fontana & D. Mutolo (Eds.) Cough: Pathophysiology diagnosis and treatment (pp. 13\u201324). Springer. https:\/\/doi.org\/10.1007\/978-3-030-48571-9_2","DOI":"10.1007\/978-3-030-48571-9_2"},{"issue":"1","key":"e_1_3_2_43_1","article-title":"Anatomy and neuro-pathophysiology of the cough reflex arc","volume":"7","author":"Polverino M.","year":"2012","unstructured":"Polverino, M., Polverino, F., Fasolino, M., And\u00f2, F., Alfieri, A., & De Blasio, F. (2012). Anatomy and neuro-pathophysiology of the cough reflex arc. Respiratory Medicine, 7(1). https:\/\/doi.org\/10.1186\/2049-6958-7-5","journal-title":"Respiratory Medicine"},{"issue":"3","key":"e_1_3_2_44_1","article-title":"Presentation of the therapy program for management of chronic cough","volume":"33","author":"Ribeiro V. V.","year":"2021","unstructured":"Ribeiro, V. V., Lopes, L. W., & Behlau, M. (2021). Presentation of the therapy program for management of chronic cough. CoDAS, 33(3), Article e20200057. https:\/\/doi.org\/10.1590\/2317-1782\/20202020057","journal-title":"CoDAS"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.11606\/issn.1679-9836.v96i3p172-176"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00203-6"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2014.4.1.3"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00125-9"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21427"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1271"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2017.03.020"},{"issue":"6","key":"e_1_3_2_53_1","first-page":"2087","article-title":"Laryngeal dysfunction in cough hypersensitivity syndrome: A cross-sectional observational study","volume":"6","author":"Vertigan A. E.","year":"2018","unstructured":"Vertigan, A. E., Kapela, S. M., Kearney, E. K., & Gibson, P. G. (2018). Laryngeal dysfunction in cough hypersensitivity syndrome: A cross-sectional observational study: The Journal of Allergy and Clinical Immunology, 6(6), 2087\u20132095. https:\/\/doi.org\/10.1016\/j.jaip.2018.04.015","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.064337"},{"issue":"3","key":"e_1_3_2_55_1","first-page":"421","article-title":"The function and gating mechanism of TRPV1 channel and the application of its modulators in drug research and development","volume":"50","author":"Wei X. M.","year":"2023","unstructured":"Wei, X. M., Yang, Q. F., Tian, J. H., Yang, H., & Ding, J. J. (2023). The function and gating mechanism of TRPV1 channel and the application of its modulators in drug research and development. Progress in Biochemistry and Biophysics, 50(3), 421\u2013436. https:\/\/doi.org\/10.16476\/j.pibb.2022.0198","journal-title":"Progress in Biochemistry and Biophysics"},{"issue":"1","key":"e_1_3_2_56_1","first-page":"3","article-title":"Airway receptors","volume":"125","author":"Widdicombe J.","year":"2001","unstructured":"Widdicombe, J. (2001a). Airway receptors Physiology, 125(1\u20132), 3\u201315. https:\/\/doi.org\/10.1016\/S0034-5687(00)00201-2","journal-title":"Physiology"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.5.16451"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10003"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00155.2006"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.100.1.41"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70021-0"}],"container-title":["Journal of Speech, Language, and Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.asha.org\/doi\/pdf\/10.1044\/2026_JSLHR-26-00206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:43:03Z","timestamp":1791920583000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.asha.org\/doi\/10.1044\/2026_JSLHR-26-00206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":60,"alternative-id":["10.1044\/2026_JSLHR-26-00206"],"URL":"https:\/\/doi.org\/10.1044\/2026_jslhr-26-00206","relation":{},"ISSN":["1092-4388","1558-9102"],"issn-type":[{"value":"1092-4388","type":"print"},{"value":"1558-9102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]}}}