{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:37:06Z","timestamp":1761489426450},"reference-count":44,"publisher":"American Speech Language Hearing Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Speech Lang Hear Res"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:p>The purpose of this study was to examine the incidence, profile, and stability of sensorineural hearing loss (SNHL) in infants diagnosed with persistent pulmonary hypertension of the newborn (PPHN). Over a five-year period, 19 of 51 infants (37%) with PPHN were diagnosed with SNHL: 16 with bilateral and 3 with unilateral impairment. This incidence of SNHL is approximately 25 times greater than observed in graduates of our intensive care nursery. The profile of SNHL in the group of 19 children was typically downward sloping. However, there was considerable variation with respect to degree of loss. In addition, progressive SNHL was identified in 5 children whose hearing worsened an average of 55 dB at 2 to 4 kHz. On retrospective analysis, the perinatal variables associated with PPHN were comparable between hearing-impaired and normal-hearing infants. In contrast, the two groups were significantly different when treatment variables, such as the duration of mechanical ventilation or amikacin, were compared. Children with SNHL were treated for longer durations as compared to normal-hearing infants. Children with SNHL were subdivided into two groups, mild and severe, based on degree of loss and treatment variables, and compared again to the normal-hearing group. Two findings emerged from this analysis. First, the duration of hyperventilation was now the only variable significantly different between children with mild SNHL and children with normal hearing. Second, comparison of the mild with the severe SNHL groups showed that the duration of hyperventilation was similar. The pathophysiology and underlying mechanisms resulting in SNHL in PPHN survivors are discussed.<\/jats:p>","DOI":"10.1044\/jshr.3406.1362","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T21:22:00Z","timestamp":1406668920000},"page":"1362-1370","source":"Crossref","is-referenced-by-count":41,"title":["Profile and Stability of Sensorineural Hearing Loss in Persistent Pulmonary Hypertension of the Newborn"],"prefix":"10.1044","volume":"34","author":[{"given":"Joseph P.","family":"Walton","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Hendricks-Munoz","sequence":"additional","affiliation":[{"name":"New York University Medical Center New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/000348948909800409","article-title":"Auditory nerve and brain stem evoked response thresholds in infants treated with gentamicin as neonates","volume":"98","author":"Adelman C.","year":"1989","journal-title":"Annals Otology, Rhinology, and Laryngology"},{"key":"e_1_3_2_3_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0095-5108(18)30915-1","article-title":"Developmental follow-up of infants with persistent pulmonary hypertension of the newborn","volume":"11","author":"Ballard R.","year":"1984","journal-title":"Clinical Perinatology"},{"key":"e_1_3_2_4_1","first-page":"651","article-title":"Neuro development and cardiopulmonary follow-up of infants with persistent pulmonary hypertension of the newborn","volume":"15","author":"Bernbaum J. O.","year":"1981","journal-title":"Pediatric Research"},{"key":"e_1_3_2_5_1","first-page":"657","article-title":"Duration of hyperventilation and outcome in infants with persistent pulmonary hypertension","volume":"81","author":"Bifano E.","year":"1988","journal-title":"Pediatrics"},{"key":"e_1_3_2_6_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5955(89)90010-5","article-title":"The nature and progression of injury in the organ of Corti during ischemia","volume":"41","author":"Billett T.","year":"1989","journal-title":"Hearing Research"},{"key":"e_1_3_2_7_1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1542\/peds.68.4.588","article-title":"Developmental follow-up of hyperventilated neonates: Preliminary observations","volume":"68","author":"Brett C.","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_3_2_8_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0095-5108(18)30909-6","article-title":"Effects of hyperventilation on cerebral blood flow and metabolism","volume":"11","author":"Bruce D.","year":"1984","journal-title":"Clinical Perinatology"},{"key":"e_1_3_2_9_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/archotol.1977.00780270073012","article-title":"Human auditory nerve action potentials and BSERs: Effects of audiogram shape and lesion location","volume":"103","author":"Coats A.","year":"1977","journal-title":"Archives Otolaryngology"},{"key":"e_1_3_2_10_1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJM198410043111401","article-title":"Prospective evaluation of hearing impairment as a sequela of acute bacterial meningitis","volume":"311","author":"Dodge P.","year":"1984","journal-title":"The New England Journal of Medicine"},{"key":"e_1_3_2_11_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0095-5108(18)30907-2","article-title":"Use of mechanical hyperventilation for clinical management of persistent pulmonary hypertension of the newborn","volume":"11","author":"Duara S.","year":"1984","journal-title":"Clinical Perinatology"},{"key":"e_1_3_2_12_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/jphysiol.1982.sp014379","article-title":"The effects of intracochlear and systemic furosemide on the properties of single cochlear nerve fibers in the cat","volume":"331","author":"Evans E.","year":"1982","journal-title":"Journal of Physiology"},{"key":"e_1_3_2_13_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.63.3.443","article-title":"Ototoxicity in neonates treated with gentamicin and kanamycin: Results of a four-year controlled follow-up study","volume":"63","author":"Finitzo-Hieber T.","year":"1979","journal-title":"Pediatrics"},{"key":"e_1_3_2_14_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0022-3476(83)80573-3","article-title":"Persistent pulmonary hypertension in the neonate: Diagnosis and management","volume":"103","author":"Fox W.","year":"1983","journal-title":"Journal of Pediatrics"},{"key":"e_1_3_2_15_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/00016487609120919","article-title":"Intermediate endocochlear potential levels induced by hypoxia","volume":"82","author":"Gafni M.","year":"1976","journal-title":"Acta Otolaryngology"},{"key":"e_1_3_2_16_1","doi-asserted-by":"crossref","unstructured":"Gersony W. (1969 August.) Evaluating cyanosis in the newborn. Hospital Practice pp. 43\u201354.","DOI":"10.1080\/21548331.1969.11705732"},{"key":"e_1_3_2_17_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0095-5108(18)30899-6","article-title":"Neonatal pulmonary hypertension: Pathophysiology, classification and etiology","volume":"11","author":"Gersony W.","year":"1984","journal-title":"Clinical Perinatology"},{"key":"e_1_3_2_18_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0022-3476(89)80091-5","article-title":"Cerebral blood flow and metabolism during and after prolonged hypocapnia in newborn lambs","volume":"115","author":"Gleason C.","year":"1989","journal-title":"Journal of Pediatrics"},{"key":"e_1_3_2_19_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1044\/jshr.3101.87","article-title":"Auditory brainstem responses to tone bursts in normally hearing subjects","volume":"31","author":"Gorga M.","year":"1988","journal-title":"Journal Speech and Hearing Research"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-198908000-00002"},{"key":"e_1_3_2_21_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00003446-198503000-00008","article-title":"Some comparisons between auditory brainstem response thresholds, latencies and the pure-tone audiogram","volume":"6","author":"Gorga M.","year":"1985","journal-title":"Ear and Hearing"},{"key":"e_1_3_2_22_1","first-page":"316","article-title":"Cerebral blood flow and oxygen consumption in the newborn dog","volume":"17","author":"Hansen N.","year":"1983","journal-title":"Pediatric Research"},{"key":"e_1_3_2_23_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1542\/peds.81.5.650","article-title":"Hearing loss in infants with persistent pulmonary hypertension","volume":"81","author":"Hendricks-Munoz K.","year":"1988","journal-title":"Journal of Pediatrics"},{"key":"e_1_3_2_24_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0378-5955(83)90078-3","article-title":"Ethacrynic acid facilates gentamicin entry into endolymph of the rat","volume":"11","author":"Huy T.","year":"1983","journal-title":"Hearing Research"},{"key":"e_1_3_2_25_1","first-page":"3","article-title":"Position statement","volume":"4","author":"Joint Committee on Infant Hearing.","year":"1983","journal-title":"Ear and Hearing"},{"key":"e_1_3_2_26_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0378-5955(85)90057-7","article-title":"Abolition of the negative endocochlear potential as a consequence of the gentamicin-furosemide interaction","volume":"20","author":"Lee S.","year":"1985","journal-title":"Hearing Research"},{"key":"e_1_3_2_27_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1055\/s-0028-1091366","article-title":"The \u201cups and downs\u201d of hearing screening: The Utah statewide program","volume":"8","author":"Mahoney T.","year":"1987","journal-title":"Seminars in Hearing"},{"key":"e_1_3_2_28_1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0022-3476(81)80605-1","article-title":"The structural basis of persistent pulmonary hypertension of the newborn infant","volume":"98","author":"Murphy J.","year":"1981","journal-title":"Journal of Pediatrics"},{"key":"e_1_3_2_29_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/00016488309132875","article-title":"Perilymph oxygenation in sudden and progressive sensorineural hearing loss","volume":"96","author":"Nagahara K.","year":"1983","journal-title":"Acta Otolaryngology"},{"key":"e_1_3_2_30_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00003446-198604000-00004","article-title":"Progressive sensorineural hearing loss in survivors of persistent fetal circulation","volume":"7","author":"Naulty C.","year":"1986","journal-title":"Ear and Hearing"},{"key":"e_1_3_2_31_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1542\/peds.78.3.417","article-title":"Unexpected hearing loss in high-risk infants","volume":"74","author":"Nield T.","year":"1986","journal-title":"Pediatrics"},{"key":"e_1_3_2_32_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5955(84)90021-2","article-title":"Dynamic aspects of guinea pig inner hair all receptor potentials with transient asphyxia","volume":"16","author":"Nuttall A.","year":"1984","journal-title":"Hearing Research"},{"key":"e_1_3_2_33_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0196-0709(80)80008-1","article-title":"Endocochlear potential and scala media oxygen tension during partial anoxia","volume":"1","author":"Nuttall A.","year":"1980","journal-title":"American Journal of Otolaryngology"},{"key":"e_1_3_2_34_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00016488509119141","article-title":"Effect of glycerol on furosemide-caused EP decrease in guinea pig neonates","volume":"99","author":"Ohmura M.","year":"1985","journal-title":"Acta Otolaryngology"},{"key":"e_1_3_2_35_1","volume-title":"Diagnosis and treatment of hearing impairment in children: A clinical manual","author":"Pappas D.","year":"1985"},{"key":"e_1_3_2_36_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0378-5955(89)90117-2","article-title":"Outer hair cell receptor current and sensorineural hearing loss","volume":"42","author":"Patuzzi R.","year":"1989","journal-title":"Hearing Research"},{"key":"e_1_3_2_37_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/000348947908800213","article-title":"Variation of endocochlear PO2 and cochlear potentials by breathing carbon dioxide","volume":"88","author":"Prazma J.","year":"1979","journal-title":"Annals of Otology, Rhinology, and Laryngology"},{"key":"e_1_3_2_38_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1044\/jshd.4603.328","article-title":"Progressive hearing loss in children: Hearing aids and other factors","volume":"24","author":"Reilly K.","year":"1981","journal-title":"Journal of Speech Hearing Disorders"},{"key":"e_1_3_2_39_1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1203\/00006450-198611000-00008","article-title":"Regional blood flow and cerebral metabolic rate of oxygen during hyperventilation in the newborn dog","volume":"20","author":"Reuter J.","year":"1986","journal-title":"Pediatric Research"},{"key":"e_1_3_2_40_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1288\/00005537-198502000-00003","article-title":"Hearing loss in early infancy: Incidence, detection and assessment","volume":"95","author":"Riko K.","year":"1985","journal-title":"Laryngoscope"},{"key":"e_1_3_2_41_1","first-page":"25","article-title":"Persistent fetal circulation","volume":"139","author":"Sell E.","year":"1985","journal-title":"Archives of the Journal of Disorders of Children"},{"key":"e_1_3_2_42_1","first-page":"249","article-title":"Progressive hearing loss following haemophilus influenza meningitis","volume":"9","author":"Silkes E.","year":"1985","journal-title":"International Journal of Pediatric Otology, Rhinology and Laryngology"},{"key":"e_1_3_2_43_1","first-page":"328","article-title":"Multi-modality evoked potentials in hypoxemia","volume":"73","author":"Sohmer H.","year":"1989","journal-title":"Electroencephalography and Clinical Neurophysiology"},{"key":"e_1_3_2_44_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/lary.1978.88.5.764","article-title":"Fetal respiratory distress causing CNS and inner ear hemorrhage","volume":"88","author":"Spector G.","year":"1978","journal-title":"Laryngoscope"},{"key":"e_1_3_2_45_1","first-page":"123","article-title":"Therapeutic management alters hearing outcome in infants with PPHN","volume":"32","author":"Walton J.","year":"1990","journal-title":"Asha"}],"container-title":["Journal of Speech, Language, and Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asha.org\/doi\/pdf\/10.1044\/jshr.3406.1362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:47:39Z","timestamp":1649814459000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.asha.org\/doi\/10.1044\/jshr.3406.1362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1044\/jshr.3406.1362"],"URL":"https:\/\/doi.org\/10.1044\/jshr.3406.1362","relation":{},"ISSN":["1092-4388","1558-9102"],"issn-type":[{"value":"1092-4388","type":"print"},{"value":"1558-9102","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}