{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:02:02Z","timestamp":1767852122941,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,2,28]],"date-time":"2002-02-28T00:00:00Z","timestamp":1014854400000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold> Anti\u2010allergic mattress encasing may provide clinical benefit in asthmatic patients. However, the effect of mattress encasings on allergen\u2010specific parameters, such as bronchial reactions to house dust mite (HDM) challenge, is not clear.<\/jats:p><jats:p><jats:bold>Objective<\/jats:bold> To investigate the effect of anti\u2010allergic mattress encasings on allergen sensitivity in patients with moderate to severe asthma.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> Twenty\u2010seven patients with asthma and HDM allergy were studied in a double\u2010blind, placebo\u2010controlled study. Concentrations of <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> (Der p 1) were measured in mattress dust before and after 1\u2003year of treatment; bronchial histamine challenge, bronchial challenge with HDM and intradermal skin challenges with HDM were performed. The number of eosinophils in peripheral blood was assessed.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> In the active group, but not in the placebo group, there was a significant reduction in Der p 1 concentration in the dust collected from the mattresses after 1\u2003year of treatment compared to before. There was a significant difference between the groups with respect to HDM\u2010induced early\u2010reaction (ER) in the airways and the number of blood eosinophils, which reflected an increase in ER and eosinophils in the placebo group without significant change in the active group. No significant improvement in PC<jats:sub>20<\/jats:sub> histamine, late\u2010reaction (LR) and skin tests was found in either groups.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> Our data suggest that encasings protect against a further increase in allergen sensitivity in asthmatic patients, so their use should be recommended.<\/jats:p>","DOI":"10.1046\/j.0022-0477.2001.01256.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T09:49:24Z","timestamp":1047376164000},"page":"117-125","source":"Crossref","is-referenced-by-count":29,"title":["The effect of anti\u2010allergic mattress encasings on house dust mite\u2010induced early\u2010 and late\u2010airway reactions in asthmatic patients. A double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"32","author":[{"given":"L. H. M.","family":"Rijssenbeek\u2010Nouwens","sequence":"first","affiliation":[]},{"given":"A. 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