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Non\u2010cardia gastric cancer usually arises in a stomach that has been inflamed over a long period and where atrophy and intestinal metaplasia have supervened. The commonest cause of gastric inflammation is infection with <jats:italic>Helicobacter pylori.<\/jats:italic> Colonization with this organism increases the relative risk of developing this cancer by about six [<jats:italic>Helicobacter<\/jats:italic> and Cancer Collaborative Group. Gut 2001; 49: 347\u201353]. Its likelihood increases with the severity and extent of the gastritis. Severity is influenced by the virulence of the infecting organism, the genetics of the host, bile reflux, dietary factors and the presence of hypochlorhydria which influences the extent, as well as the severity, of the inflammation. The only predisposing factor which can easily be manipulated is <jats:italic>H. pylori<\/jats:italic> infection, which can be successfully treated in 80\u201390% of cases using a 1\u2010week therapeutic regimen.<\/jats:p>","DOI":"10.1046\/j.1365-2036.16.s4.14.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:48:18Z","timestamp":1047354498000},"page":"83-88","source":"Crossref","is-referenced-by-count":17,"title":["<i>Gastric cancer and<\/i> Helicobacter pylori"],"prefix":"10.1111","volume":"16","author":[{"given":"A.","family":"Axon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,31]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07492-2"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.129"},{"key":"e_1_2_3_4_2","first-page":"1","volume-title":"COMA 1998 Annual Report.","author":"Committee on Medical Aspects of Food and Nutrition Policy.","year":"1999"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1447"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.3.235"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.12.2547"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350206"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409092480"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-6053(06)80014-1"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199410000-00012"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.297"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70410-0"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/35006081"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00310.x"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.347"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750024850"},{"key":"e_1_2_3_18_2","first-page":":","volume-title":"Schistomsomes, Liver Flukes and Helicobacter Pylori","author":"International Agency for Research on Cancer.","year":"1994"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90938-D"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950615)75:12<2789::AID-CNCR2820751202>3.0.CO;2-4"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_3_22_2","first-page":"639","article-title":"Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer","volume":"6","author":"Uemura N","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70143-X"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.3.346"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.6.768"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90071-1"},{"key":"e_1_2_3_27_2","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0140-6736(80)92826-3","article-title":"The effect of cimetidine on the gastric bacterial flora","author":"Ruddell WSJ","year":"1980","journal-title":"Lancet"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70135-1"}],"container-title":["Alimentary Pharmacology &amp; 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