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ILT3 represents an inhibitory receptor bearing three immunoreceptor tyrosine inhibitory motifs (ITIM). The protein mediates downregulation of cell activation through recruitment of different SH2\u2010containing protein tyrosine phosphatases. With regard to the negative immunoregulatory function particularly on B\u2010cells, ILT3 represents a candidate gene for atopy and asthma. The aim of this study was to screen for common polymorphisms in the gene coding for ILT3 and to test for association with the atopic phenotype. Using single\u2010stranded conformal polymorphism\u2010analysis and direct genomic sequencing seven polymorphisms, three mutations, a common deletion of 7\u00a0bp in the third intron and evidence for further alternative splicing of the ILT3 gene were found. Although no association was found with atopy phenotypes, it might prove useful to test for association with bronchial asthma.<\/jats:p>","DOI":"10.1046\/j.1365-2370.2000.00214.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:56:33Z","timestamp":1047408993000},"page":"121-127","source":"Crossref","is-referenced-by-count":8,"title":["Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy"],"prefix":"10.1111","volume":"27","author":[{"given":"A.","family":"Heinzmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Blattmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Forster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kuehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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