{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:45:39Z","timestamp":1773920739607,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,5,21]],"date-time":"2002-05-21T00:00:00Z","timestamp":1021939200000},"content-version":"vor","delay-in-days":719,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The recent emergence of food\u2010borne pathogens, such as <jats:italic>Salmonella enterica<\/jats:italic> serotype Enteritidis (<jats:italic>S. enteritidis<\/jats:italic>) and <jats:italic>Escherichia coli<\/jats:italic> O157:H7, has generated increasing interest in how infectious diseases can invade, persist and spread within new host populations. To alter their host range pathogens require adaptations, which ensure their circulation in a new animal population. Adaptations for circulation in different populations of vertebrate hosts seem to have been acquired multiple times within the genus <jats:italic>Salmonella<\/jats:italic> because extant <jats:italic>Salmonella<\/jats:italic> serotypes differ greatly with regard to host range. In this article, mechanisms involved in host adaptation are deduced by considering the influence of the host immune response on circulation of <jats:italic>Salmonella<\/jats:italic> serotypes within populations of vertebrate animals. This approach contributes to the identification of genes involved in host adaptation and provides new insights into the emergence of food\u2010borne pathogens.<\/jats:p>","DOI":"10.1046\/j.1365-2958.2000.01907.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T11:31:02Z","timestamp":1047468662000},"page":"1006-1014","source":"Crossref","is-referenced-by-count":179,"title":["Host adaptation and the emergence of infectious disease: the <i>Salmonella<\/i> paradigm"],"prefix":"10.1111","volume":"36","author":[{"given":"Robert A.","family":"Kingsley","sequence":"first","affiliation":[]},{"given":"Andreas J.","family":"B\u00e4umler","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,5,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200007579X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2745.1999.00384.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7063839"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/318323a0"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90420-A"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1985.0123"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.2307\/1591495"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1128\/iai.62.10.4602-4610.1994","article-title":"Host specificity of Salmonella infection in chickens and mice is expressed in vivo primarily at the level of the reticuloendothelial system","volume":"62","author":"Barrow P.A.","year":"1994","journal-title":"Infect Immun"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5450.50"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-139-6-1125"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(93)90012-Z"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.124.4.601"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1128\/iai.62.11.4747-4754.1994","article-title":"Vaccination of chickens with strain CVL30, a genetically defined Salmonella enteritidis aroA live oral vaccine candidate","volume":"62","author":"Cooper G.L.","year":"1994","journal-title":"Infect Immun"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1999.0273"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/72.1.58"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90255-7"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(91)90075-L"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)00249-Z"},{"key":"e_1_2_7_20_2","volume-title":"Salmonella\u2010species. 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