{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:33:16Z","timestamp":1773160396798,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2685,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p>We report the identification and functional analysis of\u00a0<jats:italic>katN<\/jats:italic>, a gene encoding a non\u2010haem catalase of <jats:italic>Salmonella enterica<\/jats:italic> serotype Typhimurium. <jats:italic>katN<\/jats:italic>, which is not present in <jats:italic>Escherichia coli<\/jats:italic>, is located between the <jats:italic>yciGFE and yciD E. coli<\/jats:italic> homologues in the <jats:italic>Salmonella<\/jats:italic> genome. Its predicted protein product has a molecular weight of 31\u2003826\u2003Da and is similar to the Mn\u2010catalases of <jats:italic>Lactobacillus plantarum<\/jats:italic> and <jats:italic>Thermus<\/jats:italic> spp. Its product, KatN, was visualized as a 37\u2003kDa protein in <jats:italic>E. coli<\/jats:italic> maxicells. A KatN recombinant protein, containing six histidine residues at its C\u2010terminus, was purified, and its catalase activity was\u00a0observed on a non\u2010denaturing polyacrylamide gel. KatN was also visualized by catalase activity gel staining of bacterial cell extracts. Its expression was shown to be regulated by growth phase and <jats:italic>rpoS<\/jats:italic>. Northern blotting indicated that <jats:italic>kat<\/jats:italic> forms an operon with the upstream <jats:italic>yciGFE<\/jats:italic> genes. A putative <jats:italic>rpoS<\/jats:italic>\u2010regulated promoter was identified upstream of <jats:italic>yciG<\/jats:italic>. Southern blotting revealed that <jats:italic>katN<\/jats:italic> is conserved within <jats:italic>Salmonella<\/jats:italic> serovars. <jats:italic>katN<\/jats:italic> homologues were found in <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, <jats:italic>Klebsiella pneumoniae<\/jats:italic>, <jats:italic>Klebsiella oxytoca<\/jats:italic>, <jats:italic>Enterobacter cloacae<\/jats:italic> and <jats:italic>Serratia marcescens.<\/jats:italic> A <jats:italic>katN<\/jats:italic> mutation did not appear to affect the hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) response of\u00a0<jats:italic>Salmonella<\/jats:italic>. However, the expression of <jats:italic>katN<\/jats:italic> increased the H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> resistance of unadapted cells in\u00a0the exponential phase and of <jats:italic>rpoS<\/jats:italic> mutants in stationary phase. Thus, KatN may contribute to hydrogen peroxide resistance in <jats:italic>Salmonella<\/jats:italic> in certain environmental conditions.<\/jats:p>","DOI":"10.1046\/j.1365-2958.2001.02340.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T11:36:56Z","timestamp":1047469016000},"page":"1533-1545","source":"Crossref","is-referenced-by-count":88,"title":["Identification of a non\u2010haem catalase in <i>Salmonella<\/i> and its regulation by RpoS 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