{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:39:02Z","timestamp":1777426742808,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":1040,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p> <jats:italic>The 19\u2003kDa, C\u2010terminal fragment of the major surface protein of <\/jats:italic>Plasmodium falciparum <jats:italic>(PfMSP1<jats:sub>19<\/jats:sub>) is a candidate for inclusion in a subunit malaria vaccine. In this study, we show that PfMSP1<jats:sub>19<\/jats:sub>\u2010specific antibodies, affinity purified from malaria\u2010immune human serum, can: (i) compete with invasion\u2010inhibitory monoclonal antibodies for binding to PfMSP1<jats:sub>19<\/jats:sub> and (ii) mediate inhibition of parasite growth <\/jats:italic>in vitro<jats:italic>, in the absence of complement and mononuclear cells, at physiological antibody concentrations (100\u2003\u03bcg\/ml). Parasites expressing either the K1 or 3D7 allele of PfMSP1<jats:sub>19<\/jats:sub> were equally susceptible to inhibition of merozoite invasion, indicating that the target epitopes of inhibitory antibodies are conserved or cross\u2010reactive. These studies suggest that vaccines designed to induce antibodies to PfMSP1<jats:sub>19<\/jats:sub> may protect against the high levels of malaria parasitaemia which are associated with clinical disease<\/jats:italic>.<\/jats:p>","DOI":"10.1046\/j.1365-3024.1999.00209.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:08:22Z","timestamp":1047488902000},"page":"133-139","source":"Crossref","is-referenced-by-count":126,"title":["Human antibodies to the 19\u2003kDa C\u2010terminal fragment of <i>Plasmodium falciparum<\/i> merozoite surface protein 1 inhibit parasite growth <i>in vitro<\/i>"],"prefix":"10.1111","volume":"21","author":[{"given":"ANDR\u00c9A F.","family":"EGAN","sequence":"first","affiliation":[]},{"given":"PETRA","family":"BURGHAUS","sequence":"additional","affiliation":[]},{"given":"PIERRE","family":"DRUILHE","sequence":"additional","affiliation":[]},{"given":"ANTHONY A.","family":"HOLDER","sequence":"additional","affiliation":[]},{"given":"ELEANOR M.","family":"RILEY","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,1,4]]},"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-3024.1999.00209.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-3024.1999.00209.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T21:49:08Z","timestamp":1698529748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-3024.1999.00209.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["10.1046\/j.1365-3024.1999.00209.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-3024.1999.00209.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}